Many children are born with pathologies. This is due to hereditary predisposition, features of intrauterine development and insufficient development of body systems. Physiological jaundice occurs in about 70% of newborns. The main symptom of the disease is a change in skin color. Typically, this condition goes away without medication within 10 days after birth. However, there are cases when a baby needs help to fight the disease. Most often, pediatricians prescribe Ursofalk for the treatment of jaundice.
Dosage form and composition of the drug
Ursofalk is a drug that belongs to the group of hepatoprotectors. The drug protects the liver from the harmful effects of bilirubin. Available in capsule and suspension form. The capsules must be swallowed completely without chewing or dissolving in water, therefore this form of release is suitable for the treatment of children over 3 years old.
For newborns and toddlers under the age of three, a suspension is prescribed. It is a thick liquid of homogeneous consistency, which is viscous. The suspension is sold in 250 ml glass vials. Each box comes with instructions for use and a measuring spoon.
The main active ingredient of Ursofalk is ursodeoxycholic acid. This substance is also part of the bile. Auxiliary components in the preparation:
pharmachologic effect
Ursofalk for newborns is used to treat physiological jaundice, to dissolve cholesterol stones in the gallbladder and for general protection of the liver from various negative environmental factors. The drug has the following actions:
Instructions for use
Ursofalk is prescribed to newborns when signs of jaundice appear. The drug is prescribed by a pediatrician, taking into account the need for use, the development of the disease and the age of the baby. The doctor determines the required dosage and duration of treatment. You can not independently increase or decrease the rate of the drug and interrupt the course of therapy.
If you find symptoms of adverse reactions or the development of allergies, you should consult with your pediatrician about the possibility of further use of the medication.
Ursofalk against jaundice
After birth, the baby's body needs to adjust the respiratory system. In the process of intrauterine development, the fetal cells received oxygen from the mother using a special protein - fetal hemoglobin. From the moment of the first inhalation, this substance is excreted from the body. The cells are saturated with other hemoglobin, which is responsible for the supply of oxygen to the body throughout life. During the destruction of fetal hemoglobin, bilirubin is formed, which is excreted in the urine.
If this process in the baby's body is pathological, and the newborn's liver cannot cope with the amount of bilirubin, the pigment enters the bloodstream and accumulates in the tissues of the body. As a result, the following symptoms appear:
- yellow color of the skin and eyeball;
- lethargy;
- convulsions.
In the first weeks of life, the baby's liver begins to produce glucuronic acid. It reacts with bilirubin, reduces its toxic effects and promotes rapid elimination. If the body cannot cope with the amount of bilirubin, the use of a photolamp is prescribed. Most often, treatment is prescribed at the hospital and lasts about 2 weeks (for premature babies - at least 3 weeks). The photolamp can also be used after discharge, after consulting a doctor.
The sun's rays have a positive effect on the body. Under the influence of the sun, bilirubin in the upper layers of the skin is converted into a soluble substance that is excreted from the body with waste products. The optimal time for sunbathing is no later than 11 o'clock in the afternoon, since at other hours the rays can harm the thin skin of the newborn.
If these measures do not help reduce the symptoms, compulsory treatment with hepatoprotectors is prescribed, since with a significant increase in bilirubin, it enters the brain and causes cell destruction. The drug cleanses the liver of toxins and accelerates the formation of enzymes involved in the elimination of bilirubin.
In what other cases is Ursofalk prescribed?
In addition to treating jaundice, Ursofalk is also used in the treatment of other serious diseases:
When is the drug contraindicated?
Contraindications to use:
- individual intolerance to individual components of the drug;
- serious violations in the liver;
- acute cholecystitis;
- cholangitis;
- diseases of the bile ducts, gallbladder and intestines (bleeding, inflammation, blockage);
- dysfunction of the gallbladder;
- cholesterol stones with a high calcium content.
When using several types of drugs together, their interaction must be taken into account. Ursofalk is taken with caution with the following drugs:
- Smectite, Cholestyramine - hydroxide and aluminum oxide, which are part of the composition, significantly reduce the effect of the anti-jaundice agent;
- Cyclosporine - Ursofalk enhances the excretion of the drug;
- Ciprofloxacin - the absorption of the drug is impaired.
Method of administration and dosage
For the treatment of newborns and children under 3 years of age, Ursofalk is used in the form of a suspension. It tastes good, so kids are happy to take the medicine. The dosage depends on the age, weight of the baby and the degree of development of the disease. The average dose is not more than 10 mg of the drug per 1 kg of body weight. Dosage according to instructions:
- children from 3 to 5 kg - 0.5 ml once a day (1/10 measuring spoon);
- children from 5 to 8 kg - 1.25 ml once a day (1/4 measuring spoon).
Shake the bottle before use, as sediment may form on the bottom. It is allowed to premix the suspension with breast milk.
You can give medicine to a child with a pipette or syringe without a needle, by dropping the solution along the inside of the cheek. If the drug gets into the throat, the baby may choke or start a gag reflex due to irritation of the root of the tongue. The drug can be given before and after meals.
Ursofalk is taken 1 time per day before bedtime. This is because the liver mostly works at night. In addition, at this time, the organ is in a relaxed state, therefore it is most susceptible to the effects of the drug.
Typically, the course of treatment lasts a week. Therapy can be extended if there is no improvement, or shortened if symptoms disappeared earlier, but after consulting a doctor.
Can the child have adverse reactions?
Despite the wide therapeutic effect, the drug is easily tolerated by the child's body, does not cause the development of side effects. Most often, reactions can occur when the required dosage is not observed or the course of treatment is increased. Possible complications:
- allergy in the form of skin rashes;
- nausea, vomiting, diarrhea;
- profuse regurgitation;
- pain in the abdomen.
Ursofalk's analogs
Ursofalk has a high cost and a number of contraindications, therefore, in some cases, pediatricians prescribe other drugs, for example, Ursosan. Which of these funds is best for the baby is decided by the doctor, who takes into account the individual characteristics of the child and the nature of the disease.
The following effective analogs can be distinguished:
- Ursosan. A drug based on ursodeoxycholic acid. Available in syrup and capsule form. Eliminates cholesterol stones and removes bilirubin. The dosage of Ursosan depends on body weight, the average rate is 10-15 mg per 1 kg of body weight. Causes adverse reactions in the form of rash, diarrhea, nausea.
- Hofitol (more in the article :). A French remedy that has a choleretic effect, the main substance is an extract of the leaves of the field artichoke. The drug restores liver cells, reduces the amount of urea in the blood, promotes the normal metabolism of fats and cholesterol. It is used to treat various diseases of the liver and other organs.
- Ukrliv. The Ukrainian analogue of Ursofalk is used to eliminate the symptoms of physiological jaundice in newborns and other liver diseases. The required rate is prescribed by the doctor depending on the child's body weight.
- Choludexan. It is effective for cholesterol stones, gastritis with bile reflux and jaundice. Children can be given from the first months of life.
- Flamin. Available in granules for newborns and tablets for children over 12 years old. To prepare the suspension, the contents of the sachet must be dissolved in water. It is used for hepatitis, cholecystitis and jaundice.
At birth, many children experience jaundice - a physiological phenomenon that goes away on its own within a few days and does not require treatment. If the process is delayed for a longer period, the baby is prescribed drug therapy: Ursofalk for newborns. In most cases, jaundice is treated successfully, there are no complications that affect the future health of the child.
Form and composition
Ursofalk is available in capsules and suspensions. Newborns are prescribed only the liquid form of the drug. Capsules must be swallowed completely, therefore they are indicated for children over 3 years old The active ingredient is ursodeoxycholic acid, which is part of bile.The dosage in the preparation is 250 mg per 5 ml of suspension. The medicine also contains:
- Water;
- Glycerol as a sweetener, helps to dissolve the components in the suspension, safe for newborns, used in the production of baby food;
- Xylitol - a sweetener of natural origin, safe for diabetes, has a choleretic and laxative effect;
- Microcrystalline cellulose is a naturally occurring thickener that does not react with the components of the preparation, does not change their properties;
- Sodium chloride helps dissolve other constituents;
- Benzoic acid acts as a preservative and ensures a long shelf life of Ursofalk - 4 years from the date of manufacture;
- Sodium citrate - food additive, preservative, enhances taste, maintains the consistency of the suspension;
- Propylene glycol is added to medicines as a diluent; in its pure form it has no taste or smell;
- Anhydrous citric acid - acidifier;
- Sodium cyclamate - a food additive of synthetic origin, gives a sweet taste;
- Lemon flavor.
The drug is stored for no more than 4 months from the date of opening.
Properties
With jaundice, bile stagnates in the body, which causes indigestion, bloating, colic. Ursofalk promotes:
- Removing excess bile, normalizing the level of its formation;
- Reducing cholesterol by binding and excreting it, reducing its synthesis in the liver, absorption in the intestine;
- Lowering blood sugar levels;
- Improving immunity by increasing white blood cells that fight infections and viruses;
- Increased gastric secretion.
This drug is embedded in liver cells, reduces the effect of toxic substances on it. Activation of work stimulates the production of necessary enzymes for the breakdown and elimination of harmful substances. This is due to the effectiveness of Ursofalk in the treatment of jaundice in a newborn.
Indications for use
The medicine is used to treat adults and children from birth with diseases:
- Cholelithiasis caused by high cholesterol;
- Reflux gastritis of the biliary type;
- Biliary primary stage of liver cirrhosis.
For infants, the remedy is used in the treatment of jaundice. The adaptation of the newborn to life outside the mother's womb is accompanied by the restructuring of the body to new ways of breathing. Oxygen exchange between mother and child was carried out with the help of a protein - fetal hemoglobin. In the process of getting used to new conditions, it is removed from the body. The level of other hemoglobin increases, which is involved in supplying oxygen to cells throughout a person's life. When an unnecessary form of protein breaks down, bilirubin is formed, which is excreted in the urine. In large quantities, it can lead to intoxication of the body.
In a state of postpartum stress, the baby's body does not always cope with the breakdown products of fetal hemoglobin. Bilirubin enters the bloodstream and accumulates in the tissues of the body, provoking a color change, symptoms may appear:
- Yellow tint to the skin and white of the eye;
- Lethargy;
- Convulsive states.
The danger of prolonged exposure to bilirubin on the body is the transition of jaundice to a severe, nuclear form, in which the substance penetrates into the cells of the brain, nervous system and is destroyed.
One of the first treatments for jaundice is the use of a photo lamp. If there are signs of the disease for 2 or more (in premature babies - 3) weeks, the newborn is prescribed a blood test for the content of bilirubin, with its increased level - drug treatment. The therapy is aimed at cleansing the liver of toxins and increasing the production of enzymes that process bilirubin.
Instructions for use
How to give Ursofalk? The medicine is prescribed by a doctor, in most cases the dose is not more than 10 mg per 1 kg of body weight. The vial must be shaken beforehand, since the suspension forms a precipitate. The remedy is given to the baby once a day, before bedtime, with the help of a measuring spoon, which is attached to the suspension. You can use a needleless syringe by pouring the syrup over your baby's cheek. If the drug is injected into the throat, the child may choke, or irritation of the root of the tongue will cause a gag reflex.
The medicine has a sweet taste, usually the baby takes it with pleasure. The course lasts until the level of bilirubin in the blood normalizes and the baby's condition improves, usually from 7 to 10 days. You cannot independently adjust the dosage prescribed by your doctor; you need to follow his recommendations. If the instructions for use are violated, the effectiveness of the drug may decrease.
sunlight
Regular exposure to the sun's rays on the baby's skin helps to speed up recovery - under their action, bilirubin in the upper layers of the epidermis turns into a water-soluble form, which is excreted from the body with waste products. In this case, restrictions must be observed: the most optimal time is before 11 am. In the cold season, the effectiveness of treatment is increased by replacing the sun's rays with exposure to a photolamp. The procedure can be performed in a hospital setting or you can purchase a device for home use, after consulting your doctor.
Contraindications
Ursofalk should not be taken in the following cases:
- Gallstone disease with a high calcium content;
- Individual intolerance to the components;
- Dysfunction of the gallbladder;
- Decompensated stage of liver cirrhosis;
- Inflammatory processes of the digestive organs;
- Dysfunction of the kidneys, pancreas, liver;
- Pregnancy, breastfeeding.
Side effects
Taking the drug can cause side effects:
- Increased stool, diarrhea;
- Nausea;
- Calcification of stones in the gallbladder;
- Allergic reaction;
- Regurgitation in newborns.
The baby may have insomnia, increased nervous irritability, anxiety. When using the drug, it is necessary to monitor the reaction of the child's body: the appearance of redness, rash, and other side effects is a reason to consult a doctor. Depending on the manifestation of side effects, he can reduce the dosage or choose a remedy with a similar effect, but with a different active ingredient.
When interacting with aluminum-containing drugs, the effectiveness of Ursofalk decreases, it is necessary to exclude joint administration or give drugs with a difference of two hours. Consideration should be given to interactions with hormones and drugs that lower blood fat levels, as well as antibiotics. The peculiarities of interaction with other drugs are taken into account by the doctor when prescribing ursofalk.
Analogs for newborns
There are several remedies with a similar effect that are suitable for babies from birth:
| Name | Release form | Active substance | Price |
| Capsules 250 mg, 100 pcs. (the contents are dissolved in breast milk) | Ursodeoxycholic acid | 1378 RUB | |
| Galsten | Drops 50 ml | Homeopathic doses of milk thistle, dandelion medicinal, celandine | RUB 560 |
| Hepel | Tablets, 50 pcs. (diluted with milk) | Greater celandine, hellebore white, milk thistle in homeopathic doses | 346 r |
| Elkar | Solution 50 ml | Levocarnitine | 356 r |
| Hofitol | Solution 50 ml | Artichoke leaf extract | 389 r |
The cost of Ursofalk is from 1150 rubles. for a suspension of 250 ml.
Similar drugs with ursodeoxycholic acid as an active ingredient - Grinterol, Livodexa, Exhol are not intended for newborn children. They are produced in capsule form, which cannot be swallowed by an infant.
The doctor may recommend dilution of the contents in breast milk. It is impossible to independently replace the suspension with similar capsule preparations, since it is difficult to calculate the amount, and an overdose increases side effects. Esenziale Forte has a similar effect (from the age of 12), but the drug is not used to treat infants due to age restrictions.
It is impossible to independently make a decision on taking the drug, Ursofalk for jaundice is prescribed by a doctor after studying the analyzes and the general clinical picture.
ogrudnichke.ru
Why does jaundice appear
Immediately after birth, the baby's body has not yet matured, he has to adapt to new conditions. Fetal hemoglobin is replaced by adult hemoglobin. During its breakdown, bilirubin is formed. It is difficult for the baby's liver to cope with large volumes of this substance. Bilirubin not excreted from the body is deposited on the skin. The child's body and the whites of the eyes turn yellow, hence the name of the disease.
Within two weeks, the baby's liver gets stronger and can independently produce the required amount of glucoronic acid. It combines with bilirubin, detoxifies it, making it non-toxic, and promotes excretion in the urine. If the jaundice has not passed, then the baby is prescribed hepatoprotectors. For jaundice of newborns, doctors often prescribe Ursofalk.
The main danger is that if the level of bilirubin is too high, then it can get to the brain cells and destroy them. This will disrupt the brain and cause nuclear jaundice.
Attention! Walking in the sun can help treat jaundice. If this is not possible, then babies are prescribed physiotherapy. Little patients lie under special lamps, where the dose of heat and light is automatically recorded.
Instructions for use for newborns
Ursofalk is produced in the form of a suspension with a volume of 250 milliliters or in capsules. Newborns are given the medicine in liquid form. For older children who can swallow pills, capsules have been developed. The medicine tastes sweet, but quickly becomes bitter. Ursofalk is whitish in color with a lemon scent.
The dosage and duration of admission is prescribed by the doctor. During treatment, the child must be under control. He is regularly taken blood for the determination of bilirubin. After the indicator returns to normal, Ursofalk's reception is canceled.
The daily suspension rate is 5 milliliters. Babies can be given the drug with a pipette. In severe forms of the disease, the doctor calculates up to 10 milligrams per kilogram of the baby's weight. It is recommended to take the medicine in the evening, before going to bed.
Attention! Parents often confuse suspension with syrup. But syrup is a homogeneous preparation. The suspension contains insoluble particles of suspension, therefore, the bottle must be shaken before use.
What is the composition of the medicine
Ursofalk belongs to the drug group of hepatoprotectors. Its main active ingredient is ursodeoxycholic acid. Auxiliary components include distilled water, cellulose, benzoic and citric acids, sodium citrate. The preparation also includes glycyrol and lemon flavor.
The drug has a positive effect, improves the dynamics of treatment:
- Protects the liver from harmful and toxic enzymes;
- It activates the liver, contributing to the rapid removal of bilirubin from the body;
- Accelerates the growth of protective cells that protect the liver and intestines;
- Reduces stress on the brain, thereby preventing the development of kernicterus.
The drug is incorporated into liver cells. Thanks to him, the production of enzymes is stimulated that remove toxic substances from the body. This explains the effectiveness of the drug in the treatment of newborns.
Attention! Pay attention to the child's condition while taking the drug. For rashes, diarrhea, or other side effects, see your doctor.
how correctly give Ursofalk to newborns
Children under 3 years old are allowed to drink only suspension. Usually the dosage does not exceed 5 milliliters, and the duration of treatment is 10 days.
Doctors are allowed to dilute the drug in breast milk. The medicine can be drawn into a pipette, then open the child's mouth and drip along the inside of the cheek. Or draw the suspension into an ordinary syringe without a needle and pour in in the same way.
Only a doctor can stop taking the drug. In rare severe cases, the use of Ursofalk is delayed up to six months. If the baby is prescribed other medications, then the intake of the hepatoprotector must be built taking into account other drugs. The absorption of ursodeoxycholic acid decreases if the baby drinks drugs from the antacid group. They should be taken several hours (2 to 3) earlier than Ursofalk.
Contraindications and side effects
Ursofalk is considered one of the safest drugs, because it is specially designed for newborns. But it has limitations in its application:
- Pathology of the kidneys or pancreas;
- Serious abnormalities in the liver;
- Individual sensitivity to one of the Ursofalk components;
- Diseases associated with impaired output of bile, the work of the gallbladder or intestines.
Uncontrolled use of the drug can lead to liver dysfunction. If the parents follow all the recommendations, the kids tolerate the action of the medicine well. In rare cases, the baby has disturbed sleep, nausea and loose stools. The child becomes restless, a red rash may appear on the body. In these cases, you should consult a doctor. If necessary, he will prescribe an analogue of Ursofalk.
Cost and analogs
The price depends on the region of sale, the form of release and the price policy of the pharmacy. The cost ranges from 1200 to 1400 rubles per bottle of suspension.
If the drug did not suit the baby, and the jaundice still worries the newborn, then the doctors prescribe analogues. These include: "Ursosan" in the form of capsules, "Elkar" and "Hafitol" in the form of a solution, homeopathic drops "Galstena" or tablets "Hepel" based on medicinal herbs.
lechenie-baby.ru
What is "newborn jaundice"
After the birth of a baby, his body begins to adapt to completely new conditions for him. The supply of oxygen to the child during his intrauterine development was carried out using a special type of hemoglobin - fetal. But after birth, fetal hemoglobin begins to actively break down, since the baby is no longer needed.
In the process of its decay, indirect bilirubin is formed, which is a toxic substance and is excreted from the body after a certain transformation. In a newborn baby, many systems are still far from perfect and toxic bilirubin begins to accumulate in tissues. The result is yellowing of the child's skin and eyeballs, i.e. he develops signs of classic jaundice.
Glucuronic acid produced by the liver is responsible for the processing of indirect bilirubin. It is she who binds to the substance, after which it is excreted from the body naturally along with urine. This process in a child is very slow, since the liver is not yet working at full strength.
On average, physiological jaundice lasts a maximum of two weeks. During this period of time, the baby's liver adapts and begins to fulfill its duties in full. If, after this period, the symptoms of jaundice remain, and the bilirubin levels do not decrease, then this indicates that the child has developed pathological (nuclear) jaundice.
The danger of indirect bilirubin is that, if present in excess, it can harm the brain cells. And the consequences of such a process can be very unpredictable.
How Ursofalk works
With the transition of physiological jaundice to nuclear and "Ursofalk" is prescribed for newborn babies, the drug is completely harmless. The product provides protection for the liver and rapid flow of bile.
Taking the drug improves the production of enzymes necessary for high-quality processing of indirect bilirubin and its subsequent removal from the infant's body. The liver begins to work more actively, removing accumulated poisons.
Application and dosage
"Ursofalk" for newborns is offered in the form of a suspension - the bottle contains 250 ml. The drug is also produced in capsules, which are recommended for children at an older age.
The suspension is supplied complete with a measuring spoon. For an infant, the daily dose is 5 ml. The dosage for children at an older age is calculated based on the child's body weight: for every 10 kilograms of weight - 10 ml of the drug. You need to take the suspension in the evening, just before bedtime. The shelf life of the open funds is no more than four months.
It is strictly forbidden to use the drug for the treatment of pathology without a doctor's prescription. In any case, the dosage should be selected by the doctor, based on the total amount of indirect bilirubin contained in the child's blood.
Contraindications for use and possible side effects
The instruction for the drug prohibits taking the drug in children of any age in the following cases:
- with existing liver diseases;
- disorders associated with the work of the pancreas;
- abnormalities in kidney function;
- with the existing inflammation of the biliary tract.
Side effects from using the drug include:
- sleep disorders;
- unfounded excitement of the child;
- an allergy that occurs as a reaction to the component composition of the product;
- vomiting;
- regurgitation of food;
- frequent stools;
- violations in the liver (if the recommended dosage is not followed).
The drug can be purchased at any pharmacy.
Reviews of the drug
Women who have already evaluated the work of the drug "Ursofalk" leave positive reviews about it. The tool really copes with the pathological condition in the child quickly enough. The symptomatology of jaundice in newborn babies disappears within a few days of admission. The drug has a pleasant sweetish taste, and therefore the child swallows the drug without problems.
wunderkind.su
Properties and action of Ursofalk
Ursofalk is a broad-spectrum drug used to treat disorders of the liver, gallbladder and its ducts.
The active substance of the drug is ursodeoxycholic acid. It is produced in a small amount by the human body and has a hepatoprotective effect, protecting liver cells and improving the functioning of the organ as a whole. In addition, the substance also has choleretic and immunomodulatory properties, lowers blood cholesterol levels, and promotes the elimination of toxins.
Pharmaceutical companies produce Ursolfac in the form of tablets and suspensions. However, for the treatment of newborns, it is more convenient to use the liquid form of the drug.
Some parents mistakenly call the suspension syrup. However, a syrup is a homogeneous solution, while a suspension is a suspension of fine particles in a liquid. Shake the vial with the drug before use.
In addition to ursodeoxycholic acid, the suspension contains the following auxiliary components:
- benzoic and citric acids;
- glycerol;
- sodium citrate;
- cellulose;
- lemon flavoring;
- distilled water.
Indications
For newborns, Ursofalk is prescribed for the treatment of jaundice, a frequently occurring pathology of the liver. In addition, the drug is indicated for other diseases:
- biliary atresia;
- familial fibrogenic cholestasis;
- congenital deficiency in the synthesis of primary bile acids;
- hepatitis of various origins;
- cystic fibrosis.
According to various sources, in the first week of life, jaundice occurs in 25-50% of term infants and in 70-90% of premature infants.
Doctor Komarovsky about jaundice of newborns - video
Contraindications and possible side effects
Ursofalk has the following contraindications to the appointment:
- individual sensitivity to drug components;
- gallstones visible on an x-ray;
- non-functioning gallbladder;
- acute inflammatory diseases of the bile ducts, bladder and intestines;
- cirrhosis of the liver in the stage of decompensation;
- severe impaired renal, liver, pancreas function.
The most common side effect of treatment with Ursofalk is diarrhea, which occurs on average in one in every 100 children. Very rarely observed:
- allergic reactions in the form of itching and hives;
- nausea;
- sleep disturbance;
- acute pain in the right upper abdomen;
- increased activity of hepatic enzymes.
Studies have shown that ursodeoxycholic acid, the active substance of Ursofalk, is well tolerated by children and practically does not cause side effects.
Suspension instructions
Ursofalk is taken in the evening before bedtime. The dosage depends on the baby's weight and is determined by the doctor. The duration of treatment is due to the severity of the disease, therefore it ranges from 2 weeks to several months.
Ursofalk's action can be blocked by some drugs.
- Aluminum-containing drugs, Kolestyramine and Colestipol reduce the absorption of ursodeoxycholic acid in the intestine and reduce its effectiveness. They must be taken 2 hours before using the suspension.
- Lipid-lowering drugs designed to reduce the level of fats in the blood (especially Clofibrate), the antibiotic Neomycin, some classes of hormones (progestins, estrogens) reduce Ursofalk's ability to dissolve cholesterol gallstones.
- Ursodeoxycholic acid increases the absorption of Cyclosporin from the intestine, increasing its concentration in the blood, so the dose of the drug must be adjusted by the doctor.
- In some cases, Ursofalk can reduce the absorption of Ciprofloxacin.
All these features must be taken into account by the doctor when prescribing the drug.
What can replace Ursofalk
If the newborn is too sensitive to the main or auxiliary component of the drug, it is necessary to contact the pediatrician with a question about replacing the drug.
Drug analogues - table
Drug analogues - gallery
Feedback from parents
Cured with Ursofalk in suspension. Bought with difficulty, had to book at the pharmacy. Then half a bottle remained.
SailAway
They drank for 3 days - turned white, stopped giving. According to analyzes, everything is normal (after 2 weeks).
Yburzhanka
We had a very lingering jaundice, somewhere by the 5th month it passed, they drank Ursofalk for 2 months for sure.
smishnik
https://www.u-mama.ru/forum/kids/child-health/705669/index.html
Our baby had newborn jaundice. After the next analysis, the doctor prescribed Ursofalk suspension 2 times a day for 14 days. Since we were terribly intimidated by the consequences of jaundice, we, as responsible parents, began to give our two-week-old daughter Ursofalk to drink! Oh, what a horror it was! After two doses, we almost completely stopped sleeping, the child's tummy began to ache terribly an hour after taking it. The next day everything happened again. We endured this torment for three days, after which I stopped giving Ursofalk, and a day later my daughter's condition improved and sleep returned to us.
http://irecommend.ru/content/uzhasnaya-pobochka-u-rebenka
Ursofalk did not help us when we switched to Hofitol, the jaundice went away literally in two weeks, and Ursofalk drank for 2.5 months.
Anonymous
https://www.u-mama.ru/forum/kids/0–1/418682/1.html
Ursofalk is an effective drug for the treatment of pathological jaundice in newborns. However, do not self-medicate. Before using the drug, you should definitely consult a pediatrician. Only a doctor can calculate the exact dosage and determine the duration of the course of treatment. Health to you and your baby!
pediatriya.info
Treatment of newborn jaundice
Bilirubin intoxication worsens the well-being of the baby, who becomes lethargic and drowsy. In rare cases, with elevated bilirubin, convulsions occur. When diagnosing jaundice, doctors prescribe phototherapy, during which the baby is placed under a special lamp. The beneficial radiation provokes the oxidation and gradual breakdown of bilirubin. If bilirubin remains high for more than a week, "Ursofalk" is prescribed.
This drug is available in the form of gelatin capsules and suspension in a transparent dark glass bottle. "Ursofalk" newborns are prescribed in the form of a suspension. It has a transparent white color and lemon scent. The liquid tastes sweet, but quickly becomes bitter. How does the drug help fight high bilirubin? The mechanism of operation can be found in the accompanying instructions.
For newborns, Ursofalk is available in the form of a suspension The composition of the drug "Ursofalk"
The main component of the drug "Ursofalk" is ursodeoxycholic acid. It provides a wide spectrum of drug action and has the following beneficial qualities:
- protecting liver cells from toxic enzymes;
- immunomodulatory effect by accelerating the growth of protective cells in the intestine and liver;
- activation of the liver cells, which begins to process bilirubin, helps the body to remove it as quickly as possible;
- reducing the load on the brain and preventing the transition of physical jaundice to a more severe (nuclear) form.
In addition to ursodeoxycholic acid and distilled water, "Ursofalk" contains auxiliary components. The capsules of the drug include corn starch, gelatin, sodium lauryl sulfate, magnesium stearate and titanium dioxide. The "Ursofalk" suspension contains cellulose, sodium citrate, lemon flavor, benzoic and citric acids, glycyrol.
The drug helps the liver to process bilirubin faster, and its concentration in the blood decreases Indications and contraindications for prescribing medication
Taking the drug "Ursofalk" for newborns is justified if the baby is diagnosed with physiological jaundice, hepatitis, cystic fibrosis, biliary dyskinesia. Most often, it is prescribed for jaundice, which occurs against the background of weak liver function and a lack of enzymes that remove toxic bilirubin.
With normal development, the baby's yellowness disappears in 10-14 days without the use of drugs. However, with its longer duration, the likelihood of bilirubin exposure to the brain increases dramatically. Kernicterus occurs as a result of the destruction of the subcortical nuclei of the hemispheres by bilirubin. Its consequence is encephalopathy - dystrophic changes in the brain tissue and impairment of its functions.
Contraindications
Taking the drug "Ursofalk" for newborns takes place under the strict supervision of a neonatologist or pediatrician. The medicine is not prescribed if the baby is diagnosed with:
- functional pathologies of the kidneys, liver, pancreas;
- inflammatory diseases of the intestines, gallbladder and bile ducts;
- sensitivity to drug components;
- severe liver disease.
Side effects
Incorrect and uncontrolled use of "Ursofalk" leads to liver dysfunctions, which are not easy to detect at first. With proper treatment, the drug is well tolerated by tiny patients. In some cases, the following side effects are possible:
- sleep disturbance;
- nausea;
- loose stools;
- anxiety;
- urticaria and itching of an allergic nature.
If the drug is used incorrectly, the child may experience stool disorders How to give Ursofalk to a newborn?
Prescribing the Ursofalk hepatoprotector to an infant, the pediatrician determines the daily dosage of the suspension and the duration of treatment. In doing so, he relies on the readings of the level of bilirubin in the analysis and the general condition of the child. The standard calculation of the dose of the drug is 10 mg per 1 kg of body weight. It is given after meals once a day in the evening (20 minutes before bedtime). A newborn and a baby under 3 years old can only take a suspension.
You can not press the syringe on the root of the tongue (causes vomiting) and put the syringe deep into the throat (the child may choke).
Only a doctor can cancel taking "Ursofalk" to a newborn. In difficult cases (with pathological changes in the tissues of the liver), taking the drug is delayed for 6 months or more. If other medications are prescribed in parallel with this medicine, the suspension is taken taking into account their properties. For example, drugs belonging to the antacid group reduce the absorption efficiency of ursodeoxycholic acid in the intestine. They are taken 2-3 hours earlier than the hepatoprotector.
The cost of "Ursofalk" and analog drugs
The average cost of 250 mg of Ursofalk® suspension from the German manufacturer Doctor Falk in 2016 is about 1,300 rubles. This is quite expensive and usually 1/3 of the bottle is enough to treat jaundice. The shelf life of the drug is 5 years, but many young mothers give the remaining medicine to the children's hospital, where they are very happy with such expensive drugs.
If the mother observes side effects, urticaria and itching, the doctor cancels the drug and looks for analogues - drugs that contain the same active substance (ursodeoxycholic acid) or belong to hepatoprotectors. Substitutes have their own contraindications and negative aspects, so they should be used consciously and only after the doctor selects the required dosage.
If the drug causes allergies or severe side effects, your doctor may prescribe an analog drug Substitutes "Ursofalk":
| Name | Release form | Active ingredient | Basic indications | Contraindications |
| Hofitol (Laboratoires Mayoly-Spindler, France) | Drops, tablets, injection | Field artichoke leaf extract |
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| Galstena (Bittner Richard, Austria) | Drops | Sodium sulfate, extracts of milk thistle, celandine, dandelion, phosphorus. |
|
Allergy to the components of the drug. |
| "Ursosan" ("PRO.MED", Czech Republic) | Capsules | Ursodeoxycholic acid. |
|
|
| Children's "Allohol" ("IC N Tomskhimfarm", Russia) | Tablets |
|
|
|
| "Elkar" (CJSC "Norbiopharm", Russia) * | Ampoules, oral solution | Levocarnitine |
|
|
* The instructions for the drug "Elkar" do not indicate that it is directly related to the treatment of jaundice in newborns, but pediatricians often prescribe this drug (for more details, see the article: side effects in children from the drug Elkar).
Elkar is sometimes prescribed by pediatricians for the complex treatment of jaundice "Ursosan" and "Ursofalk" - comparison of drugs
The composition of the preparations "Ursofalk" and "Ursosan" is almost identical. According to doctors, they are equally effective in treating jaundice in newborns, but the more expensive Ursofalk is easier to give to the baby, since it is produced in the form of a suspension. "Ursosan" is produced in tablets and powder, which is dissolved in milk and given with a spoon or with a syringe. The drug tastes quite bitter and can also provoke an allergic reaction.
Composition
active substance: ursodeoxycholic acid
5 ml suspension (one measuring cup) contains 250 mg ursodeoxycholic acid
excipients : benzoic acid (E 210), avicel RC-591, sodium chloride, sodium citrate, citric acid, glycerin, propylene glycol, xylitol, sodium cyclamate, lemon flavor, purified water.
Dosage form
Oral suspension.
Basic physical and chemical properties: white homogeneous suspension with fine air bubbles and lemon scent.
Pharmacological group
Drugs used to treat the liver and biliary tract. Drugs used in biliary pathology.
ATX code A05A A02.
Drugs used in liver diseases, lipotropic substances.
ATX code A05B.
Pharmacological properties
Pharmacodynamics.
A small amount of ursodeoxycholic acid is found in human bile.
After oral administration, it reduces the saturation of bile with cholesterol, suppressing its absorption in the intestine and reducing the secretion of cholesterol in bile. Perhaps due to the dispersion of cholesterol and the formation of liquid crystals, a gradual dissolution of gallstones occurs.
According to modern knowledge, it is believed that the effect of ursodeoxycholic acid in liver diseases and cholestatic diseases is due to the relative replacement of lipophilic, similar washing toxic bile acids with hydrophilic cytoprotective non-toxic ursodeoxycholic acid, an improvement in the secretory capacity of hepatocytes and immunoregulatory processes.
application to children
cystic fibrosis
The user from clinical reports concerns the long-term use of ursodeoxycholic acid (for a period of up to 10 years) in the treatment of children with hepatobiliary disorders associated with cystic fibrosis. There is evidence that the use of ursodeoxycholic acid can reduce proliferation in the bile ducts, stop the progression of histological changes and even eliminate hepatobiliary changes, provided that therapy is started in the early stages of cystic fibrosis. For better efficacy, treatment with ursodeoxycholic acid should be started immediately after the diagnosis of cystic fibrosis is clarified.
Pharmacokinetics.
When administered orally, ursodeoxycholic acid is rapidly absorbed in the empty and upper ileum by passive transport, and in the terminal ileum by active transport. The absorption rate is usually 60-80%. After absorption, bile acid is subject to almost complete conjugation in the liver with the amino acids glycine and taurine and then excreted in the bile. The clearance of the first passage through the liver is up to 60%.
Depending on the daily dose and the underlying disorder or condition of the liver, more hydrophilic ursodeoxycholic acid accumulates in the bile. At the same time, there is a relative decrease in other more lipophilic bile acids.
Under the influence of intestinal bacteria, there is a partial degradation of up to 7 ketolithocholic and lithocholic acids. Lithoholic acid is hepatotoxic and causes damage to the liver parenchyma in some animal species. In humans, only a small amount of it is absorbed, which is sulfated in the liver and thus detoxified before being excreted in the bile and finally in the feces.
The biological half-life of ursodeoxycholic acid is 3.5-5.8 days.
Indications
Symptomatic treatment of primary biliary cirrhosis (PBC) in the absence of decompensated liver cirrhosis.
For dissolving X-ray-negative cholesterol gallstones no more than 15 mm in diameter in patients with a functioning gallbladder, despite the presence of gallstone (s) in it.
For the treatment of hepatobiliary disorders in cystic fibrosis in children aged 1 month to 18 years.
Contraindications
Hypersensitivity to bile acids or any of the excipients included in the drug.
Acute cholecystitis or acute cholangitis.
Obstruction of the biliary tract (blockage of the common bile duct or duct).
Frequent attacks of biliary (hepatic) colic.
The presence of radiopaque calcified gallstones.
The contractility of the gallbladder is agitated.
Poor result of portoenterostomy or lack of adequate biliary outflow in children with biliary atresia.
Interaction with other medicinal products and other forms of interaction
Ursofalk, oral suspension (250 mg / 5 ml) should not be used simultaneously with cholestyramine, colestipol or antacids containing aluminum hydroxide or Smectite (aluminum oxide), since these drugs bind ursodeoxycholic acid in the intestine and, thus, prevent its absorption and reduce efficiency. If the use of a drug containing one of these substances is necessary, then it must be taken at least 2:00 before or 2:00 after taking Ursofalk, oral suspension, 250 mg / 5 ml.
Ursofalk suspension may interfere with intestinal absorption of cyclosporine. In this regard, in patients taking cyclosporine, the concentration of this substance in the blood should be checked and the dose adjusted if necessary.
In some cases, Ursofalk, oral suspension, 250 mg / 5 ml may reduce the absorption of ciprofloxacin.
In a clinical study in healthy volunteers, the combined use of ursodeoxycholic acid (500 mg / day) and rosuvastatin (20 mg / day) led to a slight increase in the plasma concentration of rosuvastatin. The clinical significance of this interaction, as well as the significance in other statins, has not been established.
It has been proven that ursodeoxycholic acid reduces the peak plasma concentration (C max) and the area under the curve (AUC) of the calcium antagonist nitrendipine in healthy volunteers. Careful monitoring of the result of the combined use of nifedipine and ursodeoxycholic acid is recommended. An increase in the dose of nifedipine may be required. In addition, dapsone has been reported to weaken the therapeutic effect.
This information, as well as the data obtained in vitro suggest that ursodeoxycholic acid can potentially induce the induction of cytochrome P450 3A enzymes. But in a well-designed study of interaction with budesonide, which is a proven substrate of cytochrome P450 3A, such an effect was not observed.
Estrogenic hormones, as well as drugs to reduce the concentration of cholesterol in the blood, can increase the secretion of cholesterol by the liver and thus contribute to the formation of stones in the gallbladder, is the opposite effect of the ursodeoxycholic acid used to dissolve them.
Application features
Ursofalk suspension should be taken under medical supervision.
During the first three months of treatment, it is necessary to check the liver function ACT (SGOT), ALT (SGPT) and g-GT every 4 weeks, and then every 3 months. It also makes it possible to determine the presence or absence of a response to treatment in patients with PBC, as well as to promptly identify potential liver dysfunction, especially in patients with PBC in the later stages.
Application for dissolving cholesterol gallstones
To assess the effectiveness of treatment and to identify in advance any calcification of gallstones, depending on the size of the stone, it is necessary to conduct a study of the general appearance of the gallbladder (oral cholecystography) and possible obstruction in the standing and supine position (ultrasound control) after 6-10 months from the start of treatment ...
It is not recommended to use Ursofalk, oral suspension, 250 mg / 5 ml, if the gallbladder is not visualized on X-rays or in case of calcification of stones, impaired contractility of the gallbladder or frequent hepatic colic.
Women taking Ursofalk, oral suspension, 250 mg / 5 ml for dissolving gallstones, should use an effective non-hormonal method of contraception, as hormonal contraceptives can increase the formation of gallstones.
Treatment of patients with advanced PBC
Cases of decompensation of liver cirrhosis, which may partially regress after discontinuation of therapy, have been extremely rare.
In patients with PBC, it is extremely rare that symptoms worsen at the beginning of treatment, for example, itching may worsen. In such cases, the dose of Ursofalk, oral suspension, 250 mg / 5 ml should be reduced to one glass of Ursofalk, oral suspension, 250 mg / 5 ml per day, then the dose should be gradually increased as described in the section "Dosage and Administration".
One measuring cup (equivalent to 5 ml) of Ursofalk, oral suspension, 250 mg / 5 ml contains 0.50 mmol (11.39 mg) sodium. Patients controlling sodium intake (low sodium diet) should take this into account.
Use during pregnancy and lactation.
Animal studies have shown no effect of ursodeoxycholic acid on fertility. There are no data on the effect on fertility in humans.
Data on the use of ursodeoxycholic acid in pregnant women are insufficient. Animal studies suggest reproductive toxicity early in pregnancy. Ursofalk, oral suspension, 250 mg / 5 ml should not be used during pregnancy, except in cases where it is absolutely necessary. Women of reproductive age can only take the drug if they are using reliable contraception.
It is recommended to use non-hormonal contraceptives or low estrogen oral contraceptives. Patients receiving Ursofalk, oral suspension, 250 mg / 5 ml to dissolve gallstones, should use effective non-hormonal contraception, since hormonal oral contraceptives can increase gallstones. Before starting treatment, the possibility of pregnancy should be excluded.
According to several recorded cases of the use of the drug by breastfeeding, the content of ursodeoxycholic acid in breast milk was extremely low, so one should not expect the development of any adverse events in children receiving such milk.
The ability to influence the reaction rate when driving or driving other mechanisms.
No effect was observed on the ability to drive or use machinery.
Method of administration and dosage
Opening a bottle with a childproof cap
To open the bottle, press the cap down firmly and scroll to the left.
For dissolving cholesterol gallstones
Approximately 10 mg ursodeoxycholic acid / kg body weight per day (see Table 1)
Table 1
Ursofalk suspension should be taken in the evening, before bedtime. The suspension should be taken regularly.
The time required for dissolution of gallstones is usually 6-24 months. If a decrease in the size of gallstones is not observed after 12 months of administration, therapy should not be continued.
The success of the treatment should be checked every 6 months by ultrasound or X-ray. With the help of additional studies, it is necessary to check whether the calcification of the stones did not take place over time. If this happens, treatment must be stopped.
For the symptomatic treatment of primary biliary cirrhosis (PBC)
The daily dose depends on body weight and is approximately 14 ± 2 mg ursodeoxycholic acid / kg body weight.
In the first 3 months of treatment, Ursofalk suspension should be taken throughout the day, distributing the daily dose into several doses. When liver function indicators improve, the dose can be taken 1 time per day, in the evening.
table 2
|
Body weight (kg) |
Daily dose (Mg / kg body weight) |
Measuring cup * Ursofalk suspension, 250 mg / 5 ml |
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First 3 months |
Further |
||||
|
(1 per day) |
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* 1 measuring cup (\u003d 5 ml suspension) contains 250 mg ursodeoxycholic acid.
Ursofalk suspension should be taken in accordance with the dosage regimen given in table 2. It is necessary to observe the regularity of reception.
The use of Ursofalk suspension in primary biliary cirrhosis can be unlimited in time.
In patients with primary biliary cirrhosis, it is rare at the beginning of treatment that clinical symptoms may worsen, for example, itching may increase. In this case, treatment should be continued, first taking a reduced dose of Ursofalk suspension, then gradually increasing the dose (increasing the daily dose every week) until the indicated dosage regimen is achieved.
For the treatment of hepatobiliary disorders in cystic fibrosis
For children with cystic fibrosis aged 1 month to 18 years, the dosage is 20 mg / kg / day and is divided into 2-3 doses, followed by an increase in the dose to 30 mg / kg / day, if necessary.
Children weighing less than 10 kg are very rarely affected. In such cases, it is recommended to use commercially available disposable syringes to administer the oral suspension.
Single doses for children weighing up to 10 kg should be drawn with a syringe from a measuring cup that comes with the kit, to a volume of 1.25 ml. For this, a 2 ml single-use syringe with a graduation of 0.1 ml is used. Please note that disposable syringes are not included in the package but are freely available in pharmacies.
In order to enter the required dose using a syringe:
1. Before opening the glass bottle, shake it.
3. Draw a little more suspension into the syringe than necessary.
4. Press the syringe plunger with your finger to remove air bubbles from the collected suspension.
5. Check the volume of suspension in the syringe, adjust if necessary.
6. Gently insert the contents of the syringe directly into the child's mouth.
Do not draw a syringe directly from the bottle. Do not pour unused suspension from a measuring cup or syringe back into the bottle.
Table 3
Dosing regimen for children weighing less than 10 kg: 20 mg ursodeoxycholic acid / kg / day (volume measuring device - disposable syringe)
|
Body mass |
Ursofalk, oral suspension, 250 mg / 5 ml |
|
Table 4
Dosing regimen for children weighing more than 10 kg: 20-25 mg ursodeoxycholic acid / kg / day (volume measuring device - measuring cup)
|
Body mass |
Daily dose Ursodeoxycholic acid (Mg / kg body weight) |
* Measuring cup of Ursofalk suspension 250 mg / 5 ml |
|
Description of the dosage form
Release form, composition and packaging
Capsules hard gelatinous, size no. 0, white, opaque; the contents of the capsules are white powder or granules.
Excipients: corn starch, colloidal silicon dioxide, magnesium stearate, gelatin, sodium lauryl sulfate, titanium dioxide, purified water.
10 pieces. - blisters (1) - cardboard packs.
25 pcs. - blisters (2) - cardboard packs.
25 pcs. - blisters (4) - cardboard packs.
Oral suspension white, homogeneous, containing fine air bubbles, with a lemon scent.
Excipients: benzoic acid, xylitol, glycerol, microcrystalline cellulose, propylene glycol, sodium citrate, sodium cyclamate, citric acid anhydrous, sodium chloride, lemon flavoring Givaudan PHL-134488, purified water.
250 ml - dark glass bottles (1) complete with a measuring spoon - cardboard packs.
Clinical and pharmacological group
Hepatoprotector. A drug that helps dissolve cholesterol gallstonespharmachologic effect
Hepatoprotector. It has a choleretic effect. Reduces the synthesis of cholesterol in the liver, its absorption in the intestine and concentration in bile, increases the solubility of cholesterol in the biliary system, stimulates the formation and excretion of bile. Reduces the lithogenicity of bile, increases the content of bile acids in it. It causes an increase in gastric and pancreatic secretion, enhances the activity of lipase. Has a hypoglycemic effect.
It causes partial or complete dissolution of cholesterol stones when taken orally, reduces the saturation of bile with cholesterol, which contributes to the mobilization of cholesterol from their gallstones.
It has an immunomodulatory effect, affects the immunological reactions in the liver: reduces the expression of some antigens on the membrane of hepatocytes, affects the number of T-lymphocytes, the formation of interleukin-2, reduces the number of eosinophils.
Pharmacokinetics
Data on the pharmacokinetics of the drug Ursofalk are not provided.
Indications for the use of the drug
- dissolution of cholesterol stones of the gallbladder;
- biliary reflux gastritis;
- primary biliary cirrhosis of the liver in the absence of signs of decompensation (symptomatic treatment).
Dosage regimen
Children and adults weighing less than 34 kg it is recommended to use Ursofalk in the form of a suspension.
For dissolving cholesterol gallstones prescribed in a dose of 10 mg / kg of body weight 1 time / day.
Capsules
Oral suspension
| Body mass | Number of measuring spoons | Compliant (ml) |
| 5-7 kg | 0.25 | 1.25 |
| 8-12 kg | 0.5 | 2.50 |
| 13-18 kg | 0.75 | 3.75 |
| 19-25 kg | 1 | 5.00 |
| 26-35 kg | 1.5 | 7.50 |
| 36-50 kg | 2 | 10.00 |
| 51-65 kg | 2.5 | 12.50 |
| 66-80 kg | 3 | 15.00 |
| 81-100 kg | 4 | 20.00 |
| over 100 kg | 5 | 25.00 |
The drug must be taken daily in the evening, before bedtime (do not chew the capsules) with a small amount of liquid.
Duration of treatment is 6-12 months. For the prevention of recurrent cholelithiasis, it is recommended to take the drug for several months after the stones dissolve.
For biliary reflux gastritis treatmentappoint 1 caps. (1 measuring spoon) Ursofalka daily in the evening before going to bed, drinking a little water. The course of treatment is from 10-14 days to 6 months, if necessary - up to 2 years.
For symptomatic treatment of primary biliary cirrhosisthe daily dose depends on body weight and ranges from 2 to 6 capsules (measuring spoons) (approximately 10-15 mg / kg of body weight).
Capsules
| Body mass | Daily dose | in the morning | in the afternoon | in the evening |
| 34-50 kg | 2 caps. | 1 caps. | - | 1 caps. |
| 51-65 kg | 3 caps. | 1 caps. | 1 caps. | 1 caps. |
| 66-85 kg | 4 caps. | 1 caps. | 1 caps. | 2 caps. |
| 86-110 kg | 5 caps. | 1 caps. | 2 caps. | 2 caps. |
| over 110 kg | 6 caps. | 2 caps. | 2 caps. | 2 caps. |
Oral suspension
| Body mass | Daily dose | in the morning | in the afternoon | in the evening | |
| Number of measurements spoons | Corresponding (ml) | (measuring spoons) | (measured. spoons) | (measured. spoons) | |
| 5-7 kg | 0.25 | 1.25 | - | - | 0.25 |
| 8-12 kg | 0.5 | 2.50 | - | 0.25 | 0.25 |
| 13-18 kg | 0.75 | 3.75 | 0.25 | 0.25 | 0.25 |
| 19-25 kg | 1 | 5.00 | 0.5 | 1 | 0.5 |
| 26-35 kg | 1.5 | 7.50 | 0.5 | 0.5 | 0.5 |
| 36-50 kg | 2 | 10.00 | 1 | - | 1 |
| 51-65 kg | 3 | 15.00 | 1 | 1 | 1 |
| 66-80 kg | 4 | 20.00 | 1 | 1 | 2 |
| 81-100 kg | 5 | 25.00 | 1 | 2 | 2 |
| over 100 kg | 6 | 30.00 | 2 | 2 | 2 |
Side effect
From the digestive system:diarrhea, nausea, pain in the epigastric region and right hypochondrium, calcification of gallstones, increased activity of hepatic transaminases.
In the treatment of primary biliary cirrhosis, transient decompensation of liver cirrhosis may occur, which disappears after discontinuation of the drug.
Others:allergic reactions.
Contraindications to the use of the drug
- X-ray positive (high calcium) gallstones;
- non-functioning gallbladder;
- acute inflammatory diseases of the gallbladder, bile ducts and intestines;
- cirrhosis of the liver in the stage of decompensation;
- severe renal dysfunction;
- severe liver dysfunction;
- severe dysfunction of the pancreas;
- pregnancy;
- lactation period (breastfeeding);
- hypersensitivity to drug components.
Use of the drug during pregnancy and breastfeeding
The drug is contraindicated during pregnancy and lactation (breastfeeding).
Application for violations of liver function
The drug is contraindicated in severe liver dysfunction.
Application for impaired renal function
The drug is contraindicated in severe renal impairment.
special instructions
In case of gallstone disease, the effectiveness of treatment is monitored every 6 months by means of X-ray and ultrasound examination of the biliary tract in order to prevent recurrence of cholelithiasis.
In cholestatic liver diseases, the activity of transaminases, alkaline phosphatase and gamma-glutamyl transpeptidase in the blood serum should be determined periodically.
Overdose
Overdose cases have not been identified. In case of an overdose, symptomatic treatment is performed.
Drug interactions
Cholestyramine, colestipol and antacids containing aluminum hydroxide or smectite (aluminum oxide) reduce the absorption of ursodeoxycholic acid in the intestine and thus reduce its absorption and effectiveness. If the use of drugs containing at least one of these substances is still necessary, they must be taken at least 2 hours before taking Ursofalk.
Ursodeoxycholic acid can enhance the absorption of cyclosporine from the intestine. Therefore, in patients taking cyclosporine, the doctor should check the concentration of cyclosporine in the blood and adjust the dose of cyclosporine if necessary.
In some cases, Ursofalk can reduce the absorption of ciprofloxacin.
Lipid-lowering drugs (especially clofibrate), estrogens, neomycin, or progestins increase the saturation of bile with cholesterol and may decrease the ability to dissolve cholesterol gall stones.
Terms of dispensing from pharmacies
The drug is available by prescription.
Storage conditions and periods
The drug should be stored out of the reach of children at temperatures up to 25 ° C. Shelf life of capsules - 5 years, oral suspension - 4 years.
After opening the bottle, the suspension should be used within 4 months.
"In this article, you can read the instructions for using the drug Ursofalk... The reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Ursofalk in their practice are presented. A big request is to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed that may not have been declared by the manufacturer in the annotation. Ursofalk's analogs in the presence of available structural analogs. Use for the treatment of cirrhosis of the liver and jaundice in adults, children (including infants and newborns), as well as during pregnancy and lactation. Composition of the preparation.
Ursofalk - hepatoprotector. It has a choleretic effect. Reduces the synthesis of cholesterol in the liver, its absorption in the intestine and concentration in bile, increases the solubility of cholesterol in the biliary system, stimulates the formation and excretion of bile. Reduces the lithogenicity of bile, increases the content of bile acids in it. It causes an increase in gastric and pancreatic secretion, enhances the activity of lipase. Has a hypoglycemic effect.
It causes a partial or complete dissolution of cholesterol stones when taken orally, reduces the saturation of bile with cholesterol, which helps to mobilize cholesterol from gallstones.
It has an immunomodulatory effect, affects the immunological reactions in the liver: reduces the expression of some antigens on the membrane of hepatocytes, affects the number of T-lymphocytes, the formation of interleukin-2, reduces the number of eosinophils.
Composition
Ursodeoxycholic acid + excipients.
Indications
- dissolution of cholesterol stones of the gallbladder;
- biliary reflux gastritis;
- primary biliary cirrhosis of the liver in the absence of signs of decompensation (symptomatic treatment).
Release forms
Capsules 250 mg (sometimes mistakenly called tablets).
Oral suspension (sometimes mistakenly called syrup).
Instructions for use and dosage
Children and adults weighing less than 34 kg are recommended to use Ursofalk in the form of a suspension.
To dissolve cholesterol gallstones, a dose of 10 mg / kg of body weight is prescribed once a day.
Capsules
- body weight up to 60 kg - 2 capsules per day;
- body weight 61-80 kg - 3 capsules per day;
- body weight 81-100 kg - 4 capsules per day;
- body weight over 100 kg - 5 capsules per day.
Oral suspension
- body weight 8-12 kg - the number of measuring spoons 0.50 per day;
- body weight 51-65 kg - the number of measuring spoons 2.5 per day;
- body weight 66-80 kg - the number of measuring spoons 3 per day;
- body weight 81-100 kg - the number of measuring spoons 4 per day;
- body weight over 100 kg - 5 measuring spoons per day.
The drug must be taken daily in the evening, before bedtime (do not chew the capsules) with a small amount of liquid.
Duration of treatment is 6-12 months. For the prevention of recurrent cholelithiasis, it is recommended to take the drug for several months after the stones dissolve.
For the treatment of biliary reflux gastritis, 1 capsule (1 measuring spoon) of Ursofalk is prescribed daily in the evening before bedtime, with a little water. The course of treatment is from 10-14 days to 6 months, if necessary - up to 2 years.
For the symptomatic treatment of primary biliary cirrhosis, the daily dose depends on body weight and ranges from 2 to 6 capsules (measuring spoons) (approximately 10-15 mg / kg of body weight).
Capsules
- body weight 34-50 kg - 2 capsules per day;
- body weight 51-65 kg - 3 capsules per day;
- body weight 66-85 kg - 4 capsules per day;
- body weight 86-110 kg - 5 capsules per day;
- body weight over 110 kg - 6 capsules per day.
Oral suspension
- body weight 5-7 kg - the number of measuring spoons 0.25 per day;
- body weight 8-12 kg - the number of measuring spoons 0.5 per day;
- body weight 13-18 kg - the number of measuring spoons 0.75 per day;
- body weight 19-25 kg - the number of measuring spoons 1 per day;
- body weight 26-35 kg - the number of measuring spoons 1.5 per day;
- body weight 36-50 kg - the number of measuring spoons 2 per day;
- body weight 51-65 kg - the number of measuring spoons 3 per day;
- body weight 66-80 kg - the number of measuring spoons 4 per day;
- body weight 81-100 kg - the number of measuring spoons 5 per day;
- body weight over 100 kg - 6 measuring spoons per day.
Side effect
- diarrhea;
- nausea;
- pain in the epigastric region and right hypochondrium;
- calcification of gallstones;
- allergic reactions.
Contraindications
- x-ray-positive (high calcium) gallstones;
- non-functioning gallbladder;
- acute inflammatory diseases of the gallbladder, bile ducts and intestines;
- cirrhosis of the liver in the stage of decompensation;
- severe renal dysfunction;
- severe liver dysfunction;
- severe dysfunction of the pancreas;
- pregnancy;
- lactation period (breastfeeding);
- hypersensitivity to drug components.
Application during pregnancy and lactation
The drug is contraindicated during pregnancy and lactation (breastfeeding).
Application in children
Perhaps according to the dosing regimen.
special instructions
In case of gallstone disease, the effectiveness of treatment is monitored every 6 months by means of X-ray and ultrasound examination of the biliary tract in order to prevent recurrence of cholelithiasis.
In cholestatic liver diseases, the activity of transaminases, alkaline phosphatase and gamma-glutamyl transpeptidase in the blood serum should be determined periodically.
In the treatment of primary biliary cirrhosis, transient decompensation of liver cirrhosis may occur, which disappears after discontinuation of the drug.
During treatment, women of childbearing age should use reliable methods of contraception.
Drug interactions
Cholestyramine, colestipol and antacids containing aluminum hydroxide or smectite (aluminum oxide) reduce the absorption of ursodeoxycholic acid in the intestine and thus reduce its absorption and effectiveness. If the use of drugs containing at least one of these substances is still necessary, they must be taken at least 2 hours before taking Ursofalk.
Ursodeoxycholic acid can enhance the absorption of cyclosporine from the intestine. Therefore, in patients taking cyclosporine, the doctor should check the concentration of cyclosporine in the blood and adjust the dose of cyclosporine if necessary.
In some cases, Ursofalk can reduce the absorption of ciprofloxacin.
Lipid-lowering drugs (especially clofibrate), estrogens, neomycin, or progestins increase the saturation of bile with cholesterol and may decrease the ability to dissolve cholesterol gall stones.
Analogs of the drug Ursofalk
Structural analogues for the active substance:
- Livodex;
- Urdoks;
- Urso 100;
- Ursodez;
- Ursodeoxycholic acid;
- Ursodex;
- Ursoliv;
- Ursor Rompharm;
- Ursor C;
- Ursosan;
- Choludexan;
- Exhol.
In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and see the available analogues for the therapeutic effect.
