Ibuklin Junior is a remedy that relieves pain due to the presence of paracetamol and ibuprofen in its composition. The drug is used to treat children and adults. The main purpose of the substance is to relieve pain in diseases of the joints. The instructions for use contain all the necessary information about the medicinal product, precautions, indications and contraindications.
The use of the substance must be coordinated with the attending physician, who will make the right decision on the prescription of the drug and the appropriate treatment regimen. For this reason, the drug is available from pharmacies by prescription. Country of production of Ibuklin Junior - India. The convenient form of release in the form of tablets allows you to take the medicine at any time to relieve the condition. There are features to consider when treating children.
Ibuklin Junior are pills that are used to treat such disorders in adults and children as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout. The remedy is widely used to relieve pain in the musculoskeletal system caused by inflammatory processes in the joints, bone tissue and soft tissue. The remedy is great for treating muscle pain. The instruction for use states that the medicine can be prescribed for toothache. Sometimes otolaryngologists and pediatricians prescribe pills for children with tonsillitis diagnosed, but in this case Ibuklin Junior will be an additional remedy.
Such a wide list of indications is due to the chemical composition. One tablet contains 100 milligrams of ibuprofen and 125 milligrams of paracetamol... Thanks to these components, the drug has an effective anti-inflammatory, analgesic and antipyretic effect on the body. Due to this effect, the medicine perfectly relieves pain in muscles and joints.
The mechanism of action of the active components of the drug is very simple. In diseases of the musculoskeletal system, substances are produced in the body of adults and children, which are called prostaglandins. They contribute to the appearance of pain and swelling in the place where the inflammatory process is present. Prostaglandins have a protective function. The drug reduces the production of these substances, which leads to a decrease in pain, relieve the condition, relieve inflammation, and reduce swelling. Thus, we can conclude that the considered therapeutic agent does not affect the nervous system, does not cause dependence. In other words, it does not apply to drugs. For this reason, it is allowed to be used for the treatment of children, if there are no additional contraindications.
Despite the fact that Ibuklin Junior is not a narcotic substance, it is available on prescription. We recommend that you consult a doctor before starting taking the pills, who will establish an accurate diagnosis and write the necessary prescription. The drug is not difficult to buy at the pharmacy because it is common. It is very important to store it in a dark, dry place out of the reach of children - such recommendations are given by the instructions for use. There are also analogues of the drug, which include Ibuklin, Spondifen, Brustan.
Drug dosage
Ibuklin Junior must be taken according to a strictly established scheme so that the drug does not harm health. Doctors believe that you need to take the pills by mouth 120 - 180 minutes after the main meal. You can drink the medicine before eating.
The maximum permissible dosage of the drug, which can be taken at a time, for adults and children, whose weight has exceeded 40 kilograms, is 3 tablets. In this case, it is forbidden to chew or grind them. The optimal dosage for moderate inflammatory processes is 2 tablets.
There are many conditions caused by drug overdose, so we recommend taking the drug with caution, observing the time interval. The interval between taking the medicine should be 4 to 8 hours. The larger it is, the less likely there are side effects. For people who have problems with the excretory system, we recommend taking a pill every 8 hours. It is very important to observe this rule for people over 50 years old.
It should be noted that the maximum permissible course of treatment with the drug in order to reduce pain in the joints is 5 days. Ibuklin junior can be used to normalize body temperature for 3 days. If there is no improvement in the condition, it is necessary to consult a doctor who will prescribe a different treatment regimen.
There is a special drug regimen for the treatment of children whose weight does not exceed 40 kilograms. The tablet must be crushed and dissolved in 5-10 milliliters of boiled water at room temperature, after which the medicine can be given to the child. The instruction for use states that it is forbidden to give Ibuklin Junior to babies under 3 years old. A child over 3 years old, whose weight is 13 - 20 kilograms, can be given 1 tablet 3 times in essence with an interval of 8 hours. Babies who weigh 20 - 39 kilograms can be given 2 tablets 3 times a day.
Contraindications to admission and overdose
The instructions for use contain a complete list of contraindications. These include the following conditions:
- ulcerative lesion of the duodenum and stomach;
- pregnancy at 7 - 9 months;
- optic nerve atrophy;
- diseases of the circulatory system;
- inflammation of the intestinal tissue;
- liver dysfunction;
- pyelonephritis;
- bronchial asthma;
- polyposis of the nose.
It is forbidden to take the drug if there is at least one contraindication. The drug should be used especially carefully to treat children with the described symptoms, whose body reacts very sharply to active ingredients. We also do not recommend combining Ibuklin Junior with other drugs that have a similar effect on the body.
If you exceed the permissible intake of the drug, it may lead to an overdose. Most often, this condition manifests itself in the form of diarrhea, loss of appetite and other disorders of the functioning of the gastrointestinal tract. From the side of the nervous system, lethargy of reactions, drowsiness, mood swings, clouding of consciousness, convulsions can be observed. Sometimes taking the drug can lead to headache. In some cases, Ibuklin Junior lowers blood pressure and leads to arrhythmias.
Side effects
The drug can cause many of these effects, which you need to know about before starting a course of administration. These include a variety of conditions. For example, a person may experience abrupt pain and heartburn in the stomach. Problems with liver function may occur. Some patients complain of dry mouth and constipation. The pancreas may become inflamed, which will be accompanied by pain. The drug negatively affects the function of hematopoiesis in the body. It can cause leukopenia, anemia, and a decrease in the level of platelets in the blood. Of course, this side symptom can only be determined with the help of laboratory tests.
Among the side effects from the nervous system, there is weakness, dizziness, hallucinations, disruption of the visual system due to exposure to the optic nerve. Patients may experience a deterioration in sensory sensitivity. Hallucinations are rarely a side effect. Among the adverse conditions caused by taking the drug, you can also highlight shortness of breath, heart rhythm disturbances, bronchospasm, a sharp increase in blood pressure. Symptoms like these can be very dangerous to the body.
Sometimes Ibkuklin Juior causes allergic reactions. Other side effects include tissue edema, allergic nephritis, severe renal dysfunction, cystitis, bleeding, gastrointestinal ulcers. If any of the symptoms described above occurs, you must abruptly stop taking the medication and consult a doctor.
Ibuklin junior is a drug that contains anti-inflammatory, antipyretic, analgesic substances. These are ibuprofen and paracetamol. The tablets are intended for the treatment of inflammatory processes of the musculoskeletal system. The drug is often used to normalize body temperature. It is also effective for toothache. The drug has a long list of contraindications and side effects, which we recommend that you familiarize yourself with before taking the pills. All the necessary information is contained in the instructions for use. In general, it can be noted that the drug is effective and affordable.
P N011252/02
Trade name of the drug
Ibuklin Junior®
INN or drug grouping name
Ibuprofen + Paracetamol &
Dosage form Ibuklin Junior ®
dispersible tablets [for children]
Composition of Ibuklin Junior ®
Each dispersible tablet [for children] contains:
active substances: ibuprofen 100 mg, paracetamol 125 mg;
excipients: microcrystalline cellulose 20 mg, corn starch 59.04 mg, lactose 5 mg, sodium carboxymethyl starch (type A) 30 mg, crimson dye (Ponso4R)(E124) 0.2 mg, glycerol 2 mg, colloidal silicon dioxide 5 mg, orange flavorDC100 PH 1.6 mg, pineapple flavorDC106 PH 2.5 mg, peppermint leaf oil 0.66 mg, aspartame 10 mg, magnesium stearate 1 mg, talc 3 mg.
Description Ibuklin Junior ®
Tablets of a flat-cylindrical shape, pink interspersed, with a beveled and scored on one side and a fruity-mint smell.
Pharmacotherapeutic group
combined analgesic (NSAIDs + non-narcotic analgesic).
CodeATX
M01AE51
Pharmacological properties
Pharmacodynamics
Combined drug, the action of which is due to its constituent components.
Ibuprofen - non-steroidal anti-inflammatory drug (NSAID), has an analgesic, anti-inflammatory, antipyretic effect. By inhibiting cyclooxygenase (COX) 1 and 2, it disrupts the metabolism of arachidonic acid, reduces the amount of prostaglandins (mediators of pain, inflammation and hyperthermic reaction) both in the focus of inflammation and in healthy tissues, suppresses the exudative and proliferative phases of inflammation.
Paracetamol indiscriminately blocks COX, mainly in the central nervous system, has little effect on water-salt metabolism and the mucous membrane of the gastrointestinal tract (GIT). It has analgesic and antipyretic effects. In inflamed tissues, peroxidases neutralize the effect of paracetamol on COX 1 and 2, which explains the low anti-inflammatory effect.
The effectiveness of the combination is higher than that of the individual components.
Pharmacokinetics
Ibuprofen.
Absorption - high, quickly and almost completely absorbed from the gastrointestinal tract (GIT). Time to reach maximum concentration (T FROM m Oh ) after oral administration - about 1-2 hours. The connection with blood plasma proteins is more than 90%. Half-life (T 1/2 ) - about 2 hours. Slowly penetrates into the joint cavity, accumulates in the synovial fluid, creating higher concentrations in it than in the blood plasma. After absorption, about 60% pharmacologically inactiveR-forms slowly transforms into activeS-form. Metabolized. More than 90% is excreted by the kidneys (not more than 1% unchanged) and, to a lesser extent, with bile in the form of metabolites and their conjugates.
Paracetamol.
Absorption is high, the connection with plasma proteins is less than 10% and slightly increases with overdose. Sulfate and glucuronide metabolites do not bind to plasma proteins even in relatively high concentrations. The quantity C m ah - 5-20 μg / ml, T C m Oh - 0.5-2 hours. It is fairly evenly distributed in the body fluids. Penetrates the blood-brain barrier.
About 90-95% paracetamol is metabolized in the liver to form inactive conjugates with glucuronic acid (60%), taurine (35%) and cysteine \u200b\u200b(3%), as well as a small amount of hydroxylated and deacetylated metabolites. A small part of the drug is hydroxylated by microsomal enzymes to form a highly activeN-acetyl- n- benzoquinone imine, which binds to sulfhydryl groups of glutathione. When glutathione reserves in the liver are depleted (in case of an overdose), the enzyme systems of hepatocytes can be blocked, leading to the development of their necrosis.
T 1/2 - 2-3 hours. It is excreted by the kidneys, mainly in the form of glucuronide and sulfate conjugates (less than 5% - unchanged). Less than 1% of the dose of paracetamol passes into breast milk. In children, the ability to form conjugates with glucuronic acid is lower than in adults.
Indications for useIbuklin Junior ®
Feverish syndrome.
Pain syndrome of mild or moderate intensity of various etiologies: toothache, pain during sprains, dislocations, fractures.
As an auxiliary medicine for the treatment of pain and febrile syndrome in sinusitis, tonsillitis, acute infectious and inflammatory diseases of the upper respiratory tract (pharyngitis, tracheitis, laryngitis).
Contraindications
Increased individual sensitivity to the components of the drug (including other NSAIDs), gastric ulcer and duodenal ulcer in the acute phase, complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including history), severe renal failure (CC less than 30 ml / min), optic nerve damage, genetic absence of glucose-6-phosphate dehydrogenase, diseases of the blood system, period after coronary artery bypass grafting, progressive kidney disease, severe liver failure or active liver disease, confirmed hyperkalemia, active gastrointestinal bleeding, inflammatory bowel disease, childhood (up to 3 years).
Method of administration and dosage regimenIbuklin Junior ®
The drug is taken orally. Before use, the Ibuklin Junior® tablet should be dissolved in 5 ml (1 teaspoon) of water. The daily dose of the drug is taken in 2-3 doses. The minimum time interval between taking the drug is 4 hours.
Children over 3 years old.
Single dose - 1 tablet. The daily dose depends on the age and weight of the child: 3-6 years (13-20 kg) - 3 tablets per day; 6-12 years old (20-40 kg) - up to 6 tablets per day.
In case of impaired renal or liver function, the interval between doses of the drug should be at least 8 hours.
The drug should not be taken for more than 5 days as a pain reliever and more than 3 days as an antipyretic without medical supervision.
Precautions for use
Chronic heart failure, cerebrovascular disease, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, CC less than 60 ml / min, history of ulcerative lesions of the gastrointestinal tract, presence of infectionHelicobacter pylori,long-term use of NSAIDs, alcoholism, severe somatic diseases, concomitant use of oral glucocorticosteroids (including prednisolone), anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid, clopidogrel), selective serotonin reuptake inhibitors (including serotonin) , fluoxetine, paroxetine, sertraline).
Application during pregnancy and lactation
If it is necessary to use the drug Ibuklin Junior® during pregnancy and lactation (breastfeeding), the expected benefits of therapy for the mother and the potential risk for the fetus or child should be carefully weighed.
If it is necessary to use it in the first trimester of pregnancy, long-term use of the drug Ibuklin Junior should be excluded.
If necessary, short-term use of the drug Ibuklin Junior® during lactation is usually not required to stop breastfeeding.
IN experimental research the embryotoxic, teratogenic and mutagenic effects of the components of the Ibuklin Junior® preparation have not been established.
Overdose symptoms, measures for overdose relief
Symptoms: gastrointestinal disorders (abdominal pain, diarrhea, nausea, vomiting, anorexia, pain in the epigastric region), increased prothrombin time, bleeding 12-48 hours later, lethargy, drowsiness, depression, headache, tinnitus, impaired consciousness, disturbances heart rate, decreased blood pressure, manifestations of hepato- and nephrotoxicity, convulsions, possibly the development of hepatonecrosis.
Treatment: gastric lavage during the first 4 hours; alkaline drinking, forced diuresis; activated carbon inside, the introduction of donorsSH-groups and precursors of the synthesis of glutathione - methionine 8-9 hours after an overdose andN- acetylcysteine \u200b\u200borally or intravenously after 12 hours, antacids; hemodialysis; symptomatic therapy. The need for additional therapeutic measures (further administration of methionine, intravenous administrationN-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after taking it.
Possible side effects when using the drug
In therapeutic doses, the drug is usually well tolerated.
From the digestive system: rarely - dyspeptic symptoms, with prolonged use in high doses - hepatotoxic effect.
Co sides of the hematopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis.
Allergic reactions: rarely - skin rash, itching, urticaria.
If side effects occur, you should stop taking the drug and consult a doctor.Interaction with other medicinal products and (or) food
With the simultaneous use of the drug Ibuklin Junior® with drugs, the development of various interaction effects is possible.
Long-term combined use with paracetamol increases the risk of developing nephrotoxic effects.
The combination with ethanol, glucocorticosteroids, corticotropin increases the risk of erosive and ulcerative lesions of the gastrointestinal tract.
Ibuprofen enhances the action of direct (heparin) and indirect (coumarin and indandion derivatives) anticoagulants, thrombolytic agents (alteplase, anistreplase, streptokinase, urokinase), antiplatelet agents, colchicine - the risk of hemorrhagic complications increases.
Enhances the hypoglycemic effect of insulin and oral hypoglycemic drugs.
Weakens the effects of antihypertensive drugs and diuretics (by inhibiting the synthesis of renal prostaglandins).
Increases the concentration in the blood of digoxin, lithium and methotrexate preparations.
Caffeine enhances the analgesic effect of ibuprofen.
Cyclosporine and gold preparations increase nephrotoxicity.
Cefamandol, cefoperazone, cefotetan, valproic acid, plikamycin increase the incidence of hypoprothrombinemia.
Antacids and cholestyramine reduce drug absorption.
Myelotoxic drugs contribute to the manifestation of the drug's hematotoxicity.
special instructions
The feasibility of using the drug as an antipyretic agent is decided in each case, depending on the severity, nature and tolerance of the febrile syndrome.
Ibuprofen can mask objective signs of infectious diseases, therefore, ibuprofen therapy in patients with infectious diseases should be prescribed with caution.
To reduce the risk of developing adverse events from the gastrointestinal tract, the minimum effective dose should be used with the minimum possible short course.
With the simultaneous use of indirect anticoagulants, it is necessary to monitor the indicators of the blood coagulation system.
Avoid the combined use of the drug Ibuklin Junior ® with other NSAIDs.
With prolonged (more than 5 days) administration of the drug, it is necessary to monitor the peripheral blood and the functional state of the liver.
The drug can distort the results of laboratory tests in the quantitative determination of glucose, uric acid in the blood serum, 17-ketosteroids (the drug must be discontinued 48 hours before the study).
Influence on the ability to drive vehicles, mechanisms
During the period of treatment, the patient should refrain from engaging in potentially hazardous activities that require increased attention and speed of psychomotor reactions.
Release form Ibuklin Junior ®
Dispersible tablets [for children] 100 mg + 125 mg.
10 tablets per PVC / A blisterl.
By 1, 2 or 20 blisters together with instructions for use in a cardboard box.
Availability and price in pharmacies Ibuklin Junior
Storage conditions
Store in a dry, protected by light and out of reach of children, at a temperature not exceeding 25 ° C.
Shelf life
5 years. Do not use after the expiration date printed on the package.
Terms of dispensing from pharmacies
On prescription.
Manufacturer
Dr. Reddy of Laboratories Ltd.
hyderabad, Andhra Pradesh, India
Production site address
Dr. Reddy of Laboratories Ltd.
Plots 137, 138 and 146, Sri Venkateswara Cooperative Industrial Complex, Bollaram, Jinnaram Mandal, MedakDistrict, Andhra Pradesh, India.
Consumer claims should be sent to:
Representative office of "Dr. Reddy" with Laboratories Ltd. ":
Tablets - 1 tab .:
- active ingredients: ibuprofen 100 mg, paracetamol 125 mg;
- excipients: microcrystalline cellulose 20 mg, corn starch 59.04 mg, lactose 5 mg, sodium carboxymethyl starch (type A) 30 mg, crimson dye (Ponso 4R) (E124) 0.2 mg, glycerol 2 mg, colloidal silicon dioxide 5 mg, orange flavor DC 100 PH * 1.6 mg, pineapple flavor DC 106 PH ** 2.5 mg, peppermint oil 0.66 mg, aspartame 10 mg, magnesium stearate 1 mg, talc 3 mg.
Composition of orange flavoring agent DC 100 PH: gum arabic 81-86%; aromatic additive 13-18%; butylhydroxyanisole less than 0.01%.
Composition of pineapple flavoring agent DC 106 PH: lactose 52-57%; gum arabic 31-36%; aromatic additive identical to natural 4-9%; propylene glycol less than 2%; aromatic additive less than 2%; natural aroma additive less than 2%; aroma additive less than 0.1%.
Dispersible tablets [for children] 100 mg + 125 mg.
10 tablets in a PVC / Al blister.
1, 2 or 20 blisters, together with instructions for use, in a cardboard box.
Description of the dosage form
Round flat-cylindrical pink tablets interspersed, with a beveled and scored on one side, with a characteristic odor.
pharmachologic effect
Combined analgesic (NSAIDs + non-narcotic analgesic).
Pharmacokinetics
Ibuprofen.
Absorption - high, quickly and almost completely absorbed from the gastrointestinal tract (GIT). The time to reach the maximum concentration (TCmax) after oral administration is about 1-2 hours. The connection with blood plasma proteins is more than 90%. The half-life (T1 / 2) is about 2 hours. It slowly penetrates into the joint cavity, accumulates in the synovial fluid, creating higher concentrations in it than in the blood plasma. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. Metabolized. More than 90% is excreted by the kidneys (not more than 1% unchanged) and, to a lesser extent, with bile in the form of metabolites and their conjugates.
Paracetamol.
Absorption is high, the connection with plasma proteins is less than 10% and slightly increases with overdose. Sulfate and glucuronide metabolites do not bind to plasma proteins even in relatively high concentrations. The value of Cmax is 5-20 μg / ml, TCmax is 0.5-2 hours. It is fairly evenly distributed in the body fluids. Penetrates the blood-brain barrier.
About 90-95% of paracetamol is metabolized in the liver to form inactive conjugates with glucuronic acid (60%), taurine (35%) and cysteine \u200b\u200b(3%), as well as a small amount of hydroxylated and deacetylated metabolites. A small part of the drug is hydroxylated by microsomal enzymes to form the highly active N-acetyl-n-benzoquinone imine, which binds to sulfhydryl groups of glutathione. When glutathione stores in the liver are depleted (in case of overdose), the enzyme systems of hepatocytes can be blocked, leading to the development of their necrosis.
T1 / 2 - 2-3 hours. It is excreted by the kidneys, mainly in the form of glucuronide and sulfate conjugates (less than 5% - unchanged). Less than 1% of the dose of paracetamol passes into breast milk. In children, the ability to form conjugates with glucuronic acid is lower than in adults.
Pharmacodynamics
Combined drug, the action of which is due to its constituent components.
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that has an analgesic, anti-inflammatory, antipyretic effect. By inhibiting cyclooxygenase (COX) 1 and 2, it disrupts the metabolism of arachidonic acid, reduces the amount of prostaglandins (mediators of pain, inflammation and hyperthermic reaction) both in the focus of inflammation and in healthy tissues, suppresses the exudative and proliferative phases of inflammation.
Paracetamol indiscriminately blocks COX, mainly in the central nervous system, has little effect on water-salt metabolism and the mucous membrane of the gastrointestinal tract (GIT). It has analgesic and antipyretic effects. In inflamed tissues, peroxidases neutralize the effect of paracetamol on COX 1 and 2, which explains the low anti-inflammatory effect.
The effectiveness of the combination is higher than that of individual components.
Clinical pharmacology
Combined analgesic-antipyretic.
Indications for use of Ibuklin Junior
Feverish syndrome.
Pain syndrome of mild or moderate intensity of various etiologies: toothache, pain during sprains, dislocations, fractures.
As an adjunct drug for the treatment of pain and febrile syndrome in sinusitis, tonsillitis, acute infectious and inflammatory diseases of the upper respiratory tract (pharyngitis, tracheitis, laryngitis).
Contraindications to the use of Ibuklin Junior
Increased individual sensitivity to the components of the drug (including other NSAIDs), gastric ulcer and duodenal ulcer in the acute phase, complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including history), severe renal failure (CC less than 30 ml / min), optic nerve damage, genetic absence of glucose-6-phosphate dehydrogenase, diseases of the blood system, period after coronary artery bypass grafting, progressive kidney disease, severe liver failure or active liver disease, confirmed hyperkalemia, active gastrointestinal bleeding, inflammatory bowel disease, childhood (up to 3 years).
With dedication
Chronic heart failure, cerebrovascular diseases, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, CC less than 60 ml / min, history of ulcerative lesions of the gastrointestinal tract, presence of Helicobacter pylori infection, long-term use of NSAIDs, alcoholism, severe somatic diseases , concomitant use of oral glucocorticosteroids (including prednisolone), anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid, clopidogrel), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, serotraline).
Ibuklin junior Application during pregnancy and children
If it is necessary to use the drug Ibuklin Junior® during pregnancy and lactation (breastfeeding), the expected benefits of therapy for the mother and the potential risk for the fetus or child should be carefully weighed.
If it is necessary to use it in the first trimester of pregnancy, long-term use of the drug Ibuklin Junior should be excluded.
If necessary, short-term use of the drug Ibuclin Junior® during lactation, termination of breastfeeding is usually not required.
In experimental studies, the embryotoxic, teratogenic and mutagenic effects of the components of the Ibuklin Junior® drug have not been established.
Ibuklin junior Side effects
In therapeutic doses, the drug is usually well tolerated.
From the side of the digestive system: rarely - dyspeptic phenomena, with prolonged use in high doses - hepatotoxic effect.
From the hematopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis.
Allergic reactions: rarely - skin rash, itching, urticaria.
If side effects occur, you should stop taking the drug and consult a doctor.
Drug interactions
development of various interaction effects is possible.
Long-term combined use with paracetamol increases the risk of developing nephrotoxic effects.
The combination with ethanol, glucocorticosteroids, corticotropin increases the risk of erosive and ulcerative lesions of the gastrointestinal tract.
Ibuprofen enhances the effect of direct (heparin) and indirect (coumarin and indandion derivatives) anticoagulants, thrombolytic agents (alteplase, anistreplase, streptokinase, urokinase), antiplatelet agents, colchicine the risk of hemorrhagic complications increases.
Enhances the hypoglycemic effect of insulin and oral hypoglycemic drugs.
Weakens the effects of antihypertensive drugs and diuretics (by inhibiting the synthesis of renal prostaglandins).
Increases the concentration in the blood of digoxin, lithium and methotrexate preparations.
Caffeine enhances the analgesic effect of ibuprofen.
Cyclosporine and gold preparations increase nephrotoxicity.
Cefamandol, cefoperazone, cefotetan, valproic acid, plicamycin increase the incidence of hypoprothrombinemia.
Antacids and cholestyramine reduce drug absorption.
Myelotoxic drugs contribute to the manifestation of the drug's hematotoxicity.
Dosage of Ibuklin Junior
The drug is taken orally. Before use, the Ibuklin Junior® tablet should be dissolved in 5 ml (1 teaspoon) of water. The daily dose of the drug is taken in 2-3 doses. The minimum time interval between taking the drug is 4 hours.
Children over 3 years old.
Single dose - 1 tablet. The daily dose depends on the age and weight of the child: 3-6 years (13-20 kg) - 3 tablets per day; 6-12 years old (20-40 kg) - up to 6 tablets per day.
In case of impaired renal or liver function, the interval between doses of the drug should be at least 8 hours.
The drug should not be taken for more than 5 days as an anesthetic and more than 3 days as an antipyretic without medical supervision.
Overdose
Symptoms: gastrointestinal disturbances (abdominal pain, diarrhea, nausea, vomiting, anorexia, epigastric pain), increased prothrombin time, bleeding after 12-48 hours, lethargy, drowsiness, depression, headache, tinnitus, impaired consciousness , cardiac arrhythmias, lowering blood pressure, manifestations of hepato- and nephrotoxicity, convulsions, possibly the development of hepatonecrosis.
Treatment: gastric lavage for the first 4 hours; alkaline drinking, forced diuresis; activated charcoal inside, the introduction of SH-group donors and precursors of the synthesis of glutathione - methionine 8-9 hours after the overdose and N-acetylcysteine \u200b\u200binside or intravenously - after 12 hours, antacids; hemodialysis; symptomatic therapy. The need for additional therapeutic measures (further administration of methionine, intravenous administration of N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.
Precautions
The feasibility of using the drug as an antipyretic agent is decided in each case, depending on the severity, nature and tolerance of the febrile syndrome.
Ibuprofen can mask objective signs of infectious diseases, therefore, ibuprofen therapy in patients with infectious diseases should be prescribed with caution.
To reduce the risk of developing adverse events from the gastrointestinal tract, the minimum effective dose should be used with the minimum possible short course.
With the simultaneous use of indirect anticoagulants, it is necessary to monitor the indicators of the blood coagulation system.
Avoid co-administration of Ibuclin Junior® with other NSAIDs.
With prolonged (more than 5 days) administration of the drug, it is necessary to monitor the peripheral blood and the functional state of the liver.
The drug can distort the results of laboratory tests in the quantitative determination of glucose, uric acid in the blood serum, 17-ketosteroids (the drug must be discontinued 48 hours before the study).
Influence on the ability to drive vehicles, mechanisms
During the period of treatment, the patient should refrain from engaging in potentially hazardous activities that require increased attention and speed of psychomotor reactions.
Pink tablets interspersed, flat-cylindrical, beveled and scored on one side, with a fruity-mint smell.
1 tablet contains:
- ibuprofen 100mg
- paracetamol 125mg
Excipients: microcrystalline cellulose - 20 mg, corn starch - 59.04 mg, lactose - 5 mg, sodium carboxymethyl starch (type A) - 30 mg, glycerol - 2 mg, colloidal silicon dioxide - 5 mg, crimson dye (Ponso 4R) (E124 ) - 0.2 mg, orange flavor DC 100РН - 1.6 mg, pineapple flavor DC 106РН - 2.5 mg, peppermint leaf oil - 0.66 mg, aspartame - 10 mg, magnesium stearate - 1 mg, talc - 3 mg.
The drug is dispensed on prescription.
pharmachologic effect
Ibuklin Junior is a combined drug, the action of which is due to its constituent components.
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that has an analgesic, anti-inflammatory, antipyretic effect.
By inhibiting cyclooxygenase (COX) 1 and 2, it disrupts the metabolism of arachidonic acid, reduces the amount of prostaglandins (mediators of pain, inflammation and hyperthermic reaction), both in the focus of inflammation and in healthy tissues, suppresses the exudative and proliferative phases of inflammation.
Paracetamol - indiscriminately blocks COX, mainly in the central nervous system, has little effect on water-salt metabolism and the mucous membrane of the gastrointestinal tract (GIT). It has analgesic and antipyretic effects.
In inflamed tissues, peroxidases neutralize the effect of paracetamol on COX 1 and 2, which explains the low anti-inflammatory effect.
Ibuklin weakens arthralgia at rest and during movement, reduces morning stiffness and swelling of the joints, helps to increase the range of motion.
The effectiveness of the combination is better than the individual components.
Indications for use
Ibuklin Junior is prescribed for the following diseases and pathological conditions:
Feverish conditions;
Headache;
Toothache;
Inflammation of muscles, joints, ligaments, tendons, soft tissues due to traumatic injuries (closed damage to organs and tissues without significant disruption of their structure, displacement of bones in the joints, micro-ruptures of ligaments and tendons, etc.);
To relieve pain after surgery;
Local pain along a nerve;
Muscle pain;
Acute lower back pain;
Diseases of extra-articular soft tissues;
Inflammation of the synovial membranes surrounding the tendon;
Degenerative-dystrophic diseases of the joints;
Inflammation of the sinus sinuses, palatine tonsils, larynx, pharynx, trachea.
Contraindications
- Individual sensitivity to drug components
- Peptic ulcer of the stomach and duodenum in the acute phase
- Complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including a history)
- Severe renal failure (CC less than 30 ml / min),
- Lesions of the optic nerve
- Genetic absence of glucose-6-phosphate dehydrogenase
- Diseases of the blood system
- The period after coronary artery bypass grafting,
- Progressive kidney disease
- Severe liver failure or active liver disease
- Confirmed hyperkalemia
- Active gastrointestinal bleeding
- Inflammatory bowel disease
- Children's age (up to 3 years old).
Method of administration and dosage
Be sure to read the instructions before taking. Ibuklin Junior is taken orally, after dissolving the tablet in 5 ml (teaspoon) of water. The interval between taking the resulting suspension should be at least 4 hours, and in case of impaired renal or liver function - at least 8 hours. It is recommended to divide the daily dose into 2-3 doses.
3–6 years old with a body weight of 13–20 kg: 3 tablets;
6–12 years old with a body weight of 20–40 kg: up to 6 tablets.
The duration of use of the drug without medical supervision as an antipyretic agent should not exceed 3 days, as an anesthetic - 5 days.
Application during pregnancy and lactation
If you need to use the drug Ibuklin Junior during pregnancy and lactation, you should carefully weigh the expected benefits of therapy for the mother and the potential risk to the child. If necessary, use by pregnant women in the first trimester should exclude long-term use of the drug Ibuclin Junior.
If short-term use of the drug Ibuklin Junior is necessary during lactation, breastfeeding is usually not required to be stopped.
In experimental research not installed embryotoxic, teratogenic and mutagenic effects of the components of the Ibuklin Junior preparation.
Side effects
- From the side of the digestive system: rarely - dyspeptic phenomena, with prolonged use in high doses - hepatotoxic effect.
- From the hematopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis.
- Allergic reactions: rarely - skin rash, itching, urticaria.
If side effects occur, you should stop taking the drug and consult a doctor.
Ibuklin Junior: price and analogues
Ibuklin Junior is a relatively inexpensive drug, the price for a package of 20 tablets is only about 80 rubles.
If you want to replace it, you can take either paracetamol or ibuprofen separately. Antipyretic syrups for children often include one of these components. For example, Nurofen for children contains ibuprofen. Paracetamol is also found in syrups Efferalgan, Panadol, and, of course, in a syrup called Children's Paracetamol. In addition to syrups, suppositories will help to reduce the temperature and rectal suppositories. They are especially suitable for those children who have nausea at elevated temperatures.
Other NSAIDs can also be substituted for these medications. It is only important to remember that many of them are contraindicated in children. For example, the popular (acetylsalicylic acid), which so helps to bring down the temperature for adults, is categorically contraindicated in children under 15 years old.
I think many parents are faced with sharply accelerating to terrifying values \u200b\u200bof children's temperature.
When the thermometer reads 39.6; 39.7; 39.8 - my heart is beating more and more with every tenth degree. And at around 39.8, a nervous tingling sensation begins throughout the body, because it's scary ...
Here you need to react instantly in order to prevent dangerous consequences and conditions.
As an evil, it is this temperature that everyone's favorite Nurofen and Paracetamol "do not take".
BACKGROUND
Not so long ago, both of my daughters caught a nasty virus.
☆ First, the oldest one fell ill (4 years and 9 months). Complained of sore throat, chills. She went to bed during the day (which she hasn't done for a very long time). The temperature was 37.1.
She woke up in 1.5 hours all like boiling water with a temperature of 38.9! In 20 minutes already 39.2.
I gave her paracetamol, it brought down the temperature a little bit and kept it for less than 4 hours.
20.00 - paracetamol 10 ml
All night I ran around the child, as the temperature constantly rose to 39.6 and Nurofen, drunk 3.5 hours after Paracetamol, did not help (reduced the temperature by two tenths of degrees to 39.4 in an hour). And the child was bad. Her legs became like ice and she was shaking all over from the cold - a sure sign of delirium tremens. Oily eyes, tortured look.
Then I remembered about the troicadka, crushed half of the noshpa and the suprastin and gave her a drink.
An hour later, the temperature slowly went down. My daughter was finally able to fall asleep (almost at 3 am) and I also allowed myself to close my eyes.
For myself, I decided that in the next rise in temperature I will give a mixture of Paracetamol with Nurofen. But she didn’t have time to do it, because the local police officer called to the house came before the temperature climbed up again.
The doctor, after hearing about our futile attempts to bring down and keep the temperature, advised Ibuklin - a drug that combines the active ingredients of both popular antipyretic drugs, so you don't need to mix anything. It is just the right age for us, and, as the pediatrician said, it worked well in such situations.
In cases with cold extremities and high temperatures, she advised to give an antipyretic pill together with 1/3 of a noshpa or suprastin pill (alternate taking them).
And we give the child a lot of water so that the temperature has something to come out with.
IBUKLIN CHILDREN'S DESCRIPTION
The box contained two blisters of 10 tablets each. We have already eaten one of them)
The price for 20 tablets is more than democratic - only 87 rubles.
Country of origin - India.
Active ingredients for one tablet
Ibuprofen 100 mg + Paracetamol 125 mg
The drug has analgesic, anti-inflammatory and antipyretic effects.
The instructions indicate that Ibuklin is contraindicated in children under 3 years of age. Later we had to close our eyes to this indication.
Before taking ibuclin tablet must be diluted in a teaspoon of water... The tablet dissolves quickly, readily. If you mix water at the moment of dissolution, then the process is accelerated at times. To do this, simply move the container with the tablet to dissolve.
It turns out a pleasantly smelling strawberry / raspberry light pink water with small flakes of suspension.
Taste the diluted tablet is bittersweet with menthol notes. It reminds me of bubble-gum and I like it) But the eldest daughter, having drunk a portion, said "Fu!". The youngest just screamed, but she didn't like it either.
The doctor said that at 5 years old, you can give a child 4-5 Ibuclin tablets a day.
According to the instructions:
Children 3-6 years old - 3 tablets per day
Children 6-12 years old - up to 6 tablets per day
If the diluted tablet is left standing for a while, the solution will separate.
I posted the instructions at the end of the review so as not to clutter up the text.
EXPERIENCE 1 (Admission of Ibuclin by a child at 4 years and 9 months)
I immediately went to the pharmacy, and literally an hour later we had to test a new drug at work.
It seems like a child has just played cheerfully and suddenly lies under the covers and trembles, his feet are icy, and the thermometer reads 39.5.
After taking Ibuklin with Suprastin, the temperature stopped rising, after an hour it dropped by more than a degree.
Compared to syrup, Paracetamol and Nurofen are heaven and earth! The temperature drops significantly and does not rise back for more than 4 hours.
And the daughter also stopped complaining about aching bones and joints, and became noticeably cheerful.
On that day, we gave our eldest daughter Ibuklin again in the evening. Then in the morning. No more needed. But I had to check it on the youngest.
EXPERIENCE 2 (Admission of Ibuclin to a child at 1 year and 10 months)
☆ By the evening, the joy of life began to lose already a little (1 year and 10 months). She went to bed early, the temperature was not high - 37.6.
At 01.30 she woke up crying, her temperature was already 39.1.
Recalling the past sad experience with Nurofen and Paracetamol, when I had to mix all this with each other and add noshpu with suprastin in order to somehow shift the temperature of my youngest daughter down, I immediately decided to give her Ibuklin.
I called an ambulance, they "gave the go-ahead." But I was afraid to dilute a whole pill, so I took half. Here another plus of Ibuklin showed itself in business - a small volume of the finished portion. It turned out to be easier to pour into the screaming and resisting baby.
Less volume, fewer problems. She washed down the pill with the same zeal as the syrup. So the amount of liquid I drank also suited me.
Below I will show how the temperature changed by the hour.
(Each time I write down the time and temperature, as well as taking medications, so as not to get confused to whom, what and when I gave. So do not be surprised at such bureaucracy on my part )
01.40 - reception of 0.5 tab. Ibuklina
05.15 - receiving 0.5 tab. Ibuklina
05.45 - 39.5 hands, ice feet. She put socks on the child and gave 1/3 of the socks.
09.40 - 38.9 limbs get cold again
09.50 - reception of 0.5 tab. Ibuklina
11.30 - 38.7 hands, feet, icy and blue. I start rubbing my limbs.
13.00 - whole tablet of Ibuclin + noshpa + suprastin
13.30 - 39.8 I wrap the child in a warm damp towel
Finally the doctor came. She said that in a similar situation, Ibuklin can be given as a whole tablet up to 3-4 times a day. Or a mixture of syrups Paracetamol 5-7.5ml + Nurofen 5ml. Or a mixture of tablets Paracetamol 1/3, Analgin 1/4, Suprastin 1/4. In extreme cases, the interval between taking antipyretics can be reduced to 3 hours.
If the temperature after taking the antipyretic creeps further up, we wrap the child in a damp towel or sheet. Warm cold extremities, rub. If this does not help, we call the ambulance. Until the ambulance arrives, it continues to warm cold extremities and cool the body in the area of \u200b\u200blarge blood vessels.
The doctor also said that an ambulance was called for the child in the next doorway 2 times a night to bring down the temperature. So we were not alone in the fight against delirium tremens. This is the kind of "infection" that walked and continues to walk in our city ...
14.55 - 38.5 (the child fell asleep)
When at 18.00 my daughter's temperature rose again, I tried to knock her down with Paracetamol and a bag. As a result, after half an hour the temperature dropped slightly, and after another 30 minutes it was already higher than initially.
18.00 - 39.1 Paracetamol + noshpa
Wrapping
19.50 - whole tablet of Ibuclin
01.30 - 38.9 feet get cold
01.45 - whole Ibuclin tablet + 1/3 noshpa
13.30 - whole tablet of Ibuclin + 1/3 suprastin
After that there was one more reception of Ibuklin before bedtime.
When I began to give a whole pill of Ibuclin, the temperature slowly (over an hour), but surely began to decrease and stay within reasonable limits for much longer than after taking the same Paracetamol. At first, the floor pills also "worked", but when my daughter got worse, they were no longer enough.
In total, it took us 6.5 tablets in two days. More antipyretic intake was not required.
EXPERIENCE 3 (Admission of Ibuklin junior as an adult)
Needless to say, I fell into bed the next day. Temperature 38.6. My head hurts. I can't open my eyes and move them, as this causes wild pain. Breaks all bones and joints. And I am very shivering.
And the children are already running!
I lay, lay, endured. I thought I would lie down. But no. By the evening my condition did not improve and my temperature did not change.
Then I decided to drink 1.5 tablets of Ibuclin. I drank, and wrapped myself back in the blanket, as I continued to freeze.
After about 20-30 minutes I started to sweat. Sweat poured from me like a bath. After half an hour, I wanted to get up. My head cleared up and I could even half open my eyes. The aches in my body are gone. The temperature was 37.4. And why did I suffer all day?
Ibuklin's repeated administration was not required.
I WILL GIVE A FEW CALCULATIONS
I wondered why Ibuklin was forbidden to children under 3 years old. Perhaps there is a very high concentration of active substances? Then I decided to count.
A single dose of the drug Ibuprofen is 5-10 mg / kg of the child's body weight 3-4 times a day. The maximum daily dose of the suspension is 20-30 mg / kg of body weight.
A single dose of Paracetamol is 10-15 mg / kg of the child's body weight. The maximum daily dose is no more than 60 mg per kg of the child's body weight per day.
At very high temperatures, we take the upper limit and count.
For a child weighing 11 kg (the youngest weighs so much), a single dose of ibuprofen will be 110 mg, paracetamol - 165 mg.
When taking these two antipyretics in syrup together, the following dosage was recommended:
- Paracetamol 5-7.5ml, which corresponds to 120-180mg of paracetamol
- Nurofen 5 ml, which corresponds to 100 mg ibuprofen.
Let me remind you that one tablet of Ibuclin contains Ibuprofen 100 mg and Paracetamol 125 mg.
Yes, the medicine is strong, but in cases with a very high temperature that is not knocked down, you already have to give the child a mixture of Nurofen and Paracetamol syrups, which is essentially the same Ibuklin.
But Ibuklin is easier to give. It divorces quickly, does not need to be dosed, the volume of the antipyretic is less, and, of course, it contains less sugar. Some pluses.
TOTAL
Ibuklin turned out to be an effective antipyretic agent in a rather difficult situation. My eldest daughter and I also had an analgesic effect. Neither the children nor me had any side effects, which made me very happy. Therefore, I will now constantly keep the package of pink pills in my medicine cabinet.
IBUKLIN JUNIOR INSTRUCTIONS
ஐஐஐ Thank you all for your attention to the review and good luck! ஐஐஐ
