They appear at the wrong time. The flu epidemic comes every winter and lasts until spring. When everyone is ill at work, which you get to by public transport, it is simply impossible to remain uninfected. The picture of the flu is familiar to everyone: body aches, chills, headache, weakness, lethargy, muscle pulls, the temperature goes off scale or, conversely, hangs at 37 degrees. Sometimes you just can't get sick, and you need to get rid of the symptoms as soon as possible. In such cases, various powders and tablets come to the rescue, striking a blow to acute respiratory infections and flu. These drugs include "Anvimax", patient reviews about which contain a lot of positive information.
Medication "Anvimax": indications for use
The drug "Anvimax" is suitable for symptomatic treatment and elimination of the cause of influenza A diseases, as well as for acute respiratory infections, acute respiratory viral infections, accompanied by such symptoms as fever, chills, fever, joint aches, headache, general weakness of the body. The drug "Anvimax" is not suitable for children (it is prescribed only after 12 years).
Release form and characteristics of the solution
Available in powder form in sachets or capsules. There is an "Anvimax" remedy with the taste of lemon, raspberry, lemon with honey, with the aroma of black currant. The powder is fine, the presence of white granules or
pinkish. Usually the granules are yellowish. The solution is white, cloudy, with a taste and smell indicated on the package. Taste and aromatic additives of the drug "Anvimax" (customer reviews confirm this) make taking the drug more pleasant.
Composition of the preparation and active ingredients
The drug "Anvimax" (powder) has a complex effect: antibacterial, antiviral, analgesic, anti-inflammatory and antipyretic. The main active ingredient is paracetamol. It relieves pain in muscles and joints, soothes headaches, reduces fever.
Ascorbic acid normalizes the usual amount of vitamin C in the body, in addition, promotes the development of immunity, improves regeneration processes, normalizes blood clotting and ensures normal vascular (capillary) permeability.
Calcium gluconate, which is part of the drug, replenishes the required amount of calcium in the body, resists excessive permeability of the walls of blood vessels, while reducing allergic reactions.
Rimantadine is a substance that fights the influenza A virus. Providing antiviral and anti-inflammatory effects, rimantadine
prevents the further development of influenza. In case of strain B flu, it has an anti-toxic effect.
Rutoside is a component of the drug that prevents inflammation and edema.
The loratodine component in the Anvimax preparation has a similar effect, the composition of which provides its complex action.
Powder for Anvimax solution: instructions for use, patient reviews
An adult will need 2-3 sachets of the drug per day. The amount is determined individually, depending on the complexity of the disease and the presence of symptoms. The contents of the sachet are dissolved in half a glass of warm water (not hot). Before drinking the solution, it should be stirred, since particles of active substances may remain at the bottom. The drug should be used at intervals of 4-6 hours (2-3 times a day).
The course of admission is from 2 to 5 days until the symptoms of the disease disappear (fever, chills, headache, aches). You cannot take the drug for more than 5 days. This also applies to other antiviral drugs in effervescent tablets or powders, not just Anvimax. Patient reviews indicate that the drug begins to act after three days. Some note that the effect occurs after 2 days of taking the drug.
Anvimax is also available in capsules. Adults are advised to take 1 red
and 1 blue capsule 2-3 times a day, depending on the severity of the disease. As with the powder, the duration of the treatment is 2-5 days.
If there is no improvement in health, the use of the drug should be discontinued.
Side effects
Despite the undoubted advantages of the drug, there are a number of disadvantages -
On the part of the central nervous system, drowsiness, slight fever are noted. Sometimes, on the contrary, a person becomes overexcited and too active.
In the gastrointestinal tract, side effects are manifested in the form of flatulence or diarrhea, stomach bloating, intestinal colic. More often - dry mouth.
It is also possible the appearance of an allergic reaction to the active or auxiliary substances of the drug (in particular, to flavorings). Most often it is skin redness, hives, or rashes.
If side effects appear, if they worsen or if reactions occur that are not mentioned in the instructions for the drug, immediately contact your doctor.
Contraindications
"Anvimax" (the composition and action of the drug explain this) has a number of
contraindications. First of all, the risk group includes patients suffering from diseases of the gastrointestinal tract (such as exacerbated gastritis, peptic ulcer disease, erosion, reflux, etc.).
The drug is contraindicated for people with bleeding disorders: with hemophilia or a tendency to form blood clots.
You can not use the drug for chronic alcoholics or people in a state of alcoholic intoxication.
The drug can aggravate kidney disease (cannot be used in chronic renal failure, pyelonephritis, glomerulonephritis, etc.). Also, the use of "Anvimax" is contraindicated for acute hepatitis and other liver problems.
With caution (under the supervision of a doctor) you should use Anvimax powder for people suffering from arterial hypertension.
Contraindication to use is pregnancy and the period of breastfeeding.
For any, even not acute problems with the liver, kidneys, stomach, blood vessels, heart, the drug should be used with caution, carefully listening to your body. Some components of Anvimax are dangerous. Can i give a solution to children? The answer is "definitely not". The drug is contraindicated in children under 12 years of age.
Only under the supervision of the attending physician, the drug is used by patients suffering from epilepsy, diabetes mellitus. It is also worth paying attention to those who suffer from diarrhea. Anvimax components promote greater dehydration.
Features of the drug use
As noted above, you cannot use Anvimax solution for more than 5 days.
Patients who regularly consume alcohol should consult a doctor before starting treatment with Anvimax. The doctors' comments indicate that this medication can affect the ability to drive a vehicle. Therefore, during treatment, you need to be careful with machinery, a car and engage in any activities that involve risk.
A drug for etiotropic and symptomatic therapy of respiratory viral infections
Active ingredients
Calcium gluconate, as a source of calcium ions, prevents the development of increased permeability and fragility of blood vessels, causing hemorrhagic processes in influenza and SARS, has an anti-allergic effect (the mechanism is unclear).
Rimantadin has antiviral activity against influenza A. By blocking the M 2 channels of influenza A virus, it disrupts its ability to enter cells and release ribonucleoprotein, thereby inhibiting the most important stage of viral replication. Induces the production of alpha and gamma interferons. In influenza caused by the B virus, rimantadine has an antitoxic effect.
Rutoside is an angioprotector. Reduces capillary permeability, swelling and inflammation, strengthens the vascular wall. It inhibits aggregation and increases the degree of erythrocyte deformation.
Loratadin - blocker of histamine H 1 receptors, prevents the development of tissue edema associated with the release of histamine.
Pharmacokinetics
Paracetamol
Absorption and distribution
Absorption is high. According to the results of clinical studies, the following pharmacokinetic parameters of paracetamol were established: when using capsules, C max of paracetamol in blood plasma is reached after 1.20 ± 0.72 h and is 5.01 ± 1.70 μg / ml, when powder is used - after 0.7 ± 0.39 h and is 4.79 ± 1.81 μg / ml.
Plasma protein binding - 15%. Penetrates the BBB.
Metabolism and excretion
It is metabolized in the liver in three main ways: conjugation with glucuronides, conjugation with sulfates, oxidation by microsomal liver enzymes. In the latter case, toxic intermediate metabolites are formed, which are subsequently conjugated with glutathione, and then with cysteine \u200b\u200band mercapturic acid. The main isoenzymes of cytochrome P450 for this metabolic pathway are the isoenzyme CYP2E1 (mainly), CYP1A2 and CYP3A4 (minor role). When glutathione is deficient, these metabolites can cause damage and necrosis of hepatocytes. Additional metabolic pathways are hydroxylation to 3-hydroxyparacetamol and methoxylation to 3-methoxyparacetamol, which are subsequently conjugated to glucuronides or sulfates. In adults, glucuronidation predominates. Conjugated paracetamol metabolites (glucuronides, sulfates and conjugates with glutathione) have low pharmacological (including toxic) activity.
It is excreted by the kidneys in the form of metabolites, mainly conjugates, only 3% unchanged. According to the results of clinical studies, T 1/2 of paracetamol is 3.04 ± 1.01 hours when taking the drug in capsules, 2.73 ± 0.76 hours when taking the drug in powder form.
In elderly patients, the clearance of the drug decreases and T 1/2 increases.
Vitamin C
Absorption and distribution
Absorbed from the gastrointestinal tract (mainly in the jejunum). Diseases of the gastrointestinal tract (peptic ulcer of the stomach and duodenum, constipation or diarrhea, helminthic invasion, giardiasis), the use of fresh fruit and vegetable juices, alkaline drinks reduce the absorption of ascorbic acid in the intestine. The concentration of ascorbic acid in plasma is normally approximately 10-20 μg / ml. The time to reach C max in blood plasma after oral administration is 4 hours.
Plasma protein binding - 25%. It easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye; penetrates the placental barrier. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. In deficient conditions, the concentration in leukocytes decreases later and more slowly and is considered as a better criterion for assessing deficiency than plasma concentration.
Metabolism and excretion
It is metabolized mainly in the liver to deoxyascorbic acid and then to oxaloacetic acid and ascorbate-2-sulfate.
It is excreted by the kidneys, through the intestines, with sweat unchanged and in the form of metabolites.
Pharmacokinetics in special clinical situations
Smoking and consumption of ethanol accelerate the destruction of ascorbic acid (conversion into inactive metabolites), dramatically reducing body stores.
It is excreted during hemodialysis.
Calcium gluconate
Approximately 1/5 to 1/3 part of orally administered calcium gluconate is absorbed in the small intestine; this process depends on the presence of ergocalciferol, pH, dietary characteristics, and the presence of factors that can bind calcium ions. The absorption of calcium ions increases with its deficiency and the use of a diet with a reduced content of calcium ions.
About 20% is excreted by the kidneys, the rest (80%) - by the intestines.
Rimantadin
Absorption and distribution
After oral administration, it is almost completely absorbed in the intestine. Absorption is slow. According to the results of clinical studies, the following pharmacokinetic parameters of rimantadine were established: when using capsules, C max in blood plasma is achieved after 4.53 ± 2.52 hours and is 68.2 ± 26.6 ng / ml, when using the drug in powder form - after 5.28 ± 2.54 hours and is 69 ± 19.7 ng / ml.
Plasma protein binding is about 40%. V d - 17-25 l / kg. The concentration in the discharge from the nose is 50% higher than in the plasma.
Metabolism and excretion
Metabolized in the liver. More than 90% is excreted by the kidneys within 72 hours, mainly in the form of metabolites, 15% - unchanged. According to the results of clinical studies, T 1/2 of rimantadine is 30.51 ± 9.83 hours when using the drug in the form of capsules, 33.26 ± 12.76 hours when using the drug in powder form.
Pharmacokinetics in special clinical situations
In chronic renal failure, T 1/2 increases by 2 times. In persons with renal insufficiency and in the elderly, rimantadine can accumulate in toxic concentrations if the dose is not adjusted in proportion to the decrease in CC. Hemodialysis has little effect on the clearance of rimantadine.
Rutoside
The time to reach C max in blood plasma after oral administration is 1-9 hours.
It is excreted mainly in the bile and to a lesser extent by the kidneys. T 1/2 - 10-25 h.
Loratadin
Absorption and distribution
It is quickly and completely absorbed from the digestive tract. According to the results of clinical studies, the following pharmacokinetic parameters of loratadine were established: when using the drug in the form of capsules, C max in blood plasma is achieved after 2.92 ± 1.31 h and is 2.36 ± 1.53 ng / ml, when using the drug in powder form - after 3.28 ± 1.25 h and is 1.85 ± 0.95 ng / ml.
Plasma protein binding - 97%. Does not penetrate the BBB.
Metabolism and excretion
It is metabolized in the liver with the formation of an active metabolite of descarboethoxyloratadine with the participation of cytochrome isoenzymes CYP3A4 and, to a lesser extent, CYP2D6.
It is excreted by the kidneys and bile. According to the results of clinical studies, T 1/2 of loratadine when taking capsules is 12.36 ± 6.84 hours, when using the drug in powder form - 11.29 ± 5.52 hours.
Pharmacokinetics in special clinical situations
C max in the elderly increases by 50%.
In patients with chronic renal failure and during hemodialysis, the pharmacokinetics practically does not change.
Indications
- etiotropic treatment of influenza type A;
- symptomatic treatment of colds, flu and acute respiratory viral infections, accompanied by fever, chills, nasal congestion, sore throat, pain in the joints and muscles, headache.
Contraindications
- hypersensitivity to one or more of the components that make up the drug;
- erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
- gastrointestinal bleeding;
- hemophilia;
- hemorrhagic diathesis;
- hypoprothrombinemia;
- portal hypertension;
- vitamin K deficiency;
- renal failure;
- diseases of the thyroid gland;
- acute diseases of the kidneys, liver (acute glomerulonephritis, acute pyelonephritis, acute hepatitis), or exacerbation of chronic diseases of these organs;
- chronic alcoholism;
- hypercalcemia, severe hypercalciuria;
- nephrourolithiasis;
- sarcoidosis;
- simultaneous intake of cardiac glycosides (risk of arrhythmias);
- lactose intolerance, lactase deficiency, glucose-galactose malabsorption;
- fructose intolerance (for effervescent tablets);
- phenylketonuria (for powder and effervescent tablets);
- pregnancy;
- the period of breastfeeding;
- children under 18 years of age.
Carefully the drug should be used and its use should be limited in case of epilepsy, cerebral atherosclerosis, diabetes mellitus, glucose-6-phosphate dehydrogenase deficiency, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, urolithiasis, dehydration, electrolyte disorders (risk of developing hypercalcemia, malaria) calcium nephrourolithiasis (history), hypercalciuria; as well as in elderly patients with arterial hypertension (the risk of hemorrhagic stroke increases, due to the rimantadine, which is part of the drug).
Effervescent tablets should also be prescribed with caution when taking MAO inhibitors, tricyclic antidepressants simultaneously or previously within 2 weeks; concomitant use of drugs that can adversely affect the liver (for example, inducers of liver microsomal enzymes); in the treatment of patients with recurrent formation of urate stones in the kidneys, with progressive malignant diseases, bronchial asthma.
Dosage
The drug is taken orally after meals.
The capsules should be taken with water.
The powder (contents of 1 sachet) must be dissolved in 1/2 cup (100 ml) of warm boiled water and stirred. The resulting solution should be consumed immediately after preparation.
The effervescent tablet must be dissolved in 1/2 cup of boiled warm water and stirred; the resulting solution should be consumed immediately after preparation.
Adults appoint 1 capsule P blue and 1 capsule P red (single dose) or 1 sachet of powder or 1 effervescent tab. 2-3 times / day The interval between doses of the drug is 4-6 hours.
The drug should be taken within 3-5 days (no more than 5 days) until the symptoms of the disease disappear. If there is no improvement in the patient's well-being, the patient should stop using the drug and consult a doctor.
Side effects
From the nervous system: hyperexcitability, drowsiness, tremors, hyperkinesia, dizziness, headache, flushes of blood to the face.
From the digestive system: damage to the mucous membrane of the stomach and duodenum, dyspepsia, dryness of the mucous membrane in the mouth, lack of appetite, flatulence, diarrhea.
From the urinary system: moderate pollakiuria.
From the hematopoietic system: changes in blood counts (control is required).
From the endocrine system:
Allergic reactions: angioedema, anaphylactic shock, skin rash, itching, urticaria.
From the skin: Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), acute generalized exanthematous pustulosis.
Others: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glucosuria).
Post-registration experience: During the use of AnviMax, cases of angioedema, light-headedness, fever, decreased blood pressure, urticaria, pruritus, erythema, hearing impairment, sore throat were described.
If any of the side effects indicated in the instructions are aggravated or any other side effects not indicated in the instructions are noted, the patient should immediately inform the doctor about it.
Overdose
Symptoms: during the first 24 hours after administration - pallor of the skin, nausea, diarrhea, vomiting, pain in the epigastric region; violation of glucose metabolism, metabolic acidosis, tachycardia, arrhythmia, headache, exacerbation of concomitant chronic diseases. Symptoms of liver dysfunction may appear 12-48 hours after an overdose. In severe overdose - hepatic failure with progressive encephalopathy, coma; acute renal failure with tubular necrosis (including in the absence of severe liver damage).
The overdose threshold can be lowered in elderly patients, in patients taking certain drugs (for example, inducers of liver microsomal enzymes), alcohol or suffering from wasting.
Treatment: administration of SH-group donors and precursors of glutathione-methionine synthesis within 8-9 hours after overdose and acetylcysteine \u200b\u200b- within 8 hours. Gastric lavage, symptomatic therapy. The need for additional therapeutic measures (further administration of methionine, acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time that has passed after its administration.
Drug interactions
Paracetamolreduces the effectiveness of uricosuric drugs.
The concomitant use of paracetamol in high doses increases the effect of anticoagulant drugs.
Inducers of microsomal oxidation in the liver (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications even with a small overdose.
With simultaneous use with metoclopramide, an increase in the rate of absorption of paracetamol is possible.
Long-term use of barbiturates reduces the effectiveness of paracetamol.
Microsomal oxidation inhibitors reduce the risk of hepatotoxic effects.
Rimantadin enhances the stimulating effect of caffeine.
Cimetidine reduces the clearance of rimantadine by 18%.
Vitamin C increases the concentration of benzylpenicillin in the blood.
Improves the absorption of iron preparations in the intestine (converts ferric iron to ferrous); can increase the excretion of iron while used with deferoxamine.
Increases the risk of crystalluria during treatment with short-acting salicylates and sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs with an alkaline reaction (including alkaloids).
Reduces the concentration of oral contraceptives in the blood.
Increases the total ethanol clearance, which in turn reduces the concentration of ascorbic acid in the body.
With simultaneous use, it reduces the chronotropic effect of isoprenaline.
Barbiturates and primidone increase the excretion of ascorbic acid in the urine.
Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives.
Reduces tubular reabsorption of amphetamine and tricyclic antidepressants.
Loratadin
Inhibitors of CYP3A4 and CYP2D6 increase the concentration of loratadine in the blood.
special instructions
Duration of use - no more than 5 days.
The drug should not be used in the presence of metastatic tumors.
Patients who abuse alcohol should consult a doctor before starting treatment with the drug, since paracetamol can have a damaging effect on the liver.
Influence on the ability to drive vehicles and mechanisms
During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.
Pregnancy and lactation
Use during pregnancy and during breastfeeding is contraindicated.
Childhood use
The use of the drug is contraindicated in children and adolescents under 18 years of age.
With impaired renal function
The use of the drug is contraindicated in renal failure, acute kidney disease (acute glomerulonephritis, acute pyelonephritis), or exacerbation of chronic kidney disease, nephrourolithiasis.
Storage conditions and periods
Capsules and powder should be stored out of the reach of children, in a dry, dark place at a temperature not exceeding 25 ° C.
Effervescent tablets should be stored out of the reach of children at temperatures above 25 ° C.
Shelf life of capsules and effervescent tablets is 2 years, powder for solution for oral administration is 30 months. Do not use after the expiration date printed on the package.
Anvimax for influenza, the instruction of which is always attached to the drug, is a combined drug with a pronounced antipyretic, analgesic, anti-inflammatory and antiviral effect.
Antimax for influenza can be used, since this medicine is indicated for prescription for symptomatic therapy in acute respiratory diseases of the human respiratory system that were caused by a virus.
Anvimax is widely used to treat and prevent influenza
Anvimax for colds and flu is a combined drug that contains several active substances at once. Thus, he manages to exert a complex therapeutic effect on the body.
Antimax for influenza, the instruction of which contains a full description of the drug, includes the following components:
- Ascorbic acid or a complete analogue of vitamin C. With its help, a person's immune system, blood clotting and capillary permeability are normalized. Also, this component promotes faster tissue regeneration and compensates for the lack of vitamin C in the body.
- Calcium gluconate helps to eliminate the acute inflammatory process that is invariably observed with the flu. Thus, such a component of the drug is excellent for combating acute viral infections.
- Rimantadine is a special substance that has a pronounced antiviral effect in relation to the most common type of virus - A. In addition, such a component helps to restore the normal functioning of the body's defenses.
- Loratadine is a classic virus blocker. It protects against the development of edema in diseased tissues. With its help, you can quickly eliminate the main symptoms of the presence of inflammation in the body, which are expressed in tearing, hyperemia, tissue edema, reddening of the mucous membranes, etc.
- Rutoside also helps to strengthen the immune system and make capillaries less brittle.
- Paracetamol is a substance that helps to quickly relieve fever, pain, and inflammation. This is an excellent ingredient that is approved for use by both adults and children. It is well tolerated and rarely causes side effects.
Anvimax contains substances that block the spread of viral infections
Release form
Anvimax for colds and flu (its instructions include a complete list of contraindications), today it is produced in the following dosage forms:
- Powder for oral solution... Outwardly, it looks like pale yellow granules, which can be flavored with lemon, cranberry, honey, currant or raspberry. One carton contains 6, 12 or 24 sachets of this powder.
- Oral capsules... They are packed in a blister of 10 pcs. One carton contains two capsule plates. Outwardly, they have a blue color and a gelatinous base. Base of taste and smell.
It is up to the attending physician to decide which form of the drug to use, based on the indications, age and specific condition of the person.
Contraindications
Anvimax is strictly contraindicated for children. If necessary, the child needs to use a safer antipyretic and antiviral agent, which should be selected by the supervising pediatrician.
Due to the increased toxicity and the ability to negatively affect the work of the digestive system, this medication is prohibited from taking in the presence of any acute gastrointestinal diseases. This includes an ulcer, cholecystitis, internal bleeding, pancreatic pathology, etc.
Additional complete contraindications to the use of Anvimax for the treatment of influenza are:
- Pregnancy period. According to the instructions, this medicine cannot be used in any trimester of bearing a child, since there is no exact information about the safety of the effect of its active substance on the fetus.
During pregnancy, the drug can only be used as directed by a doctor.
In addition, treatment with such a powder during breastfeeding is also prohibited. If it is necessary to prescribe Anvimax during lactation, a woman should stop breastfeeding and transfer the baby to artificial formula.
- Various serious diseases of the circulatory system.
- Acute or chronic pathologies of the cardiovascular system, as well as the period after a recent myocardial infarction.
- Chronic liver failure and hepatitis.
- Acute or chronic renal failure and general dysfunction of these organs.
- Individual intolerance of the patient to the active substances of the drug (allergy to them). In this case, the doctor must prescribe a medicine with other active substances to the patient.
In addition, the following additional contraindications are distinguished, in which it is undesirable to use this drug:
- Acute glucose deficiency.
- Diabetes.
- Alcohol dependence of the patient.
- Individual human intolerance to lactose.
With caution and only under medical supervision, elderly people, patients suffering from atherosclerosis, diarrhea and patients with arterial hypertension (due to the risk of hemorrhagic stroke) should be treated with Anvimax.
Lactose intolerance is another contraindication to the use of Anvimax
Features of taking the drug
In order for Antimax treatment to be effective and bring the expected benefits for a person, during treatment with him, the patient must adhere to the following tips:
1. The drug should be taken no longer than five days. If during this time the patient's condition does not improve, then he should consult a doctor.
2. Do not combine treatment with Anvimax and drinking alcohol, as this can adversely affect the liver.
3. Due to the fact that the drug can affect the reaction rate, while taking it, a person needs to be extremely careful when driving vehicles.
4. Due to the fact that the drug can negatively affect the work of the kidneys and liver, during treatment, the patient must regularly undergo clinical blood tests in order to be able to control his condition. In case of any deterioration, therapy should be discontinued, and the drug should be replaced with a safer analogue.
5. To reduce the toxic effects on the body, during such therapy, you should drink plenty of fluids.
6. To speed up the overall healing process, the patient is advised to stay in bed, eat a balanced diet and regularly ventilate the room.
7. Do not combine treatment with this remedy with other drugs without a doctor's prescription, as this can worsen a person's condition.
Method of administration and dosage
Antimax powder should be taken one sachet three times a day. The duration of therapy is on average 3-5 days.
In order to prepare an oral suspension, pour the contents of the powder into a glass and pour 200 ml of hot water over it. After that, mix everything thoroughly to get a homogeneous mass. You need to drink it in small sips, take it warm at a time.
Antimax capsules should be taken 1 pc. twice a day. The duration of therapy is also no more than five days.
In case of drug overdose in a person, the following symptoms may occur:
- Deterioration of liver function.
- Exacerbation of existing chronic diseases.
- Progressive renal failure.
- Heart rhythm irregularities, tachycardia and arrhythmias.
- Nausea and vomiting.
- Severe abdominal pain.
When the above signs of an overdose appear, the patient should consult a doctor as soon as possible. Treatment of this condition is symptomatic.
Anvimax helps to defeat flu and colds in the shortest possible time
Side effects
As medical practice shows, Antimax rarely causes severe adverse reactions. They usually occur when a person has taken the drug in the presence of significant contraindications to this. Therefore, this medicine can cause the following unwanted side effects:
- Disruptions in the work of the central nervous system, which will be expressed in drowsiness, headache, tremors of the limbs, irritability and dizziness.
- Deterioration in the gastrointestinal tract (nausea and vomiting, dry mouth, loss of appetite, diarrhea, bloating, flatulence, exacerbation of ulcers).
- Allergic reactions. However, skin rash, itching, hives and swelling usually occur.
- A general deterioration in well-being, which will manifest itself in weakness, discomfort, muscle pain and sleep disturbance.
AnviMax is the first Russian-made drug that has anti-inflammatory, antipyretic, interferonogenic, angioprotective, analgesic and antihistamine effects.
Thus, therapy with this drug is complex, even if only one position is included in the conservative sanitation scheme, and therefore attention should be paid to the mechanisms of action of each component separately.
In this article, we will consider why doctors prescribe Anvimax, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Anvimax can be found in the comments.
Composition and form of release
The drug is produced in the form of a mixture of granules and powder from white to yellowish-green color. The powder has a characteristic odor (lemon, cranberry, lemon with honey, black currant, raspberry). The finished solution should be cloudy.
Oral powder (dosage of biologically active substances is calculated for 1 sachet for a single use) consists of components such as:
- paracetamol - 360 mg;
- ascorbic acid - 300 mg;
- calcium gluconate monohydrate - 100 mg;
- rimantadine hydrochloride - 50 mg;
- rutoside trihydrate - 20 mg;
- loratadine - 3 mg.
Clinical and pharmacological group: a drug for etiotropic and symptomatic therapy of respiratory viral infections.
Indications for use of Anvimax
AnviMax belongs to a group that eliminates viral manifestations in a short time, and it has also proven itself very well in the treatment of conditions such as:
- SARS, colds, flu
Also used for conditions that are accompanied by fever, chills, and headache.
Pharmacological properties
The composition of Anvimax is distinguished by a well-chosen complex of components:
- Paracetamol, which is part of the drug, has an antipyretic effect, and also has an analgesic effect.
- Rimantadine is an active substance with antiviral and anti-inflammatory effects. Effectively fights the influenza A virus by blocking its ability to enter the cells of the body. Rimantadine rapidly induces the production of interferons, which relieve the symptoms of respiratory infections. With the influenza B virus, it has an anti-toxic effect. After oral administration, rimantadine is completely absorbed in the intestine, but absorption is slow. Up to 40% of the active substance binds to plasma proteins.
- Loratadine is a substance with antihistamine (antiallergic) action. Works as a blocker of histamine receptors, prevents the release of histamine and associated tissue edema. The substance is characterized by complete and rapid absorption in the gastrointestinal tract, while binding to blood proteins reaches 97%. It is metabolized in the liver, excreted from the body by the kidneys and with bile.
Rutozid belongs to the group of angioprotectors. It reduces capillary permeability, inflammation and swelling, strengthens the walls of blood vessels. - Calcium gluconate is a source of calcium ions, prevents hemorrhagic processes (arising from acute respiratory viral infections and influenza), since it affects the fragility and permeability of blood vessels. Also, calcium gluconate has antiallergic effect.
- Ascorbic acid takes part in redox processes, promotes the establishment of capillary penetration, blood clotting, and also accelerates tissue regeneration. In addition, this component has a positive effect on the development of immune responses, preventing vitamin C deficiency.
Instructions for use
According to the instructions for use, the contents of 1 sachet of Anvimax should be dissolved in half a glass of boiled warm water and drunk immediately after dissolution. Stir the solution before use.
- Adults are prescribed orally 1 sachet 2-3 times / day after meals for 3-5 days (no more than 5 days) until the symptoms of the disease disappear.
If there is no improvement in health, the drug should be discontinued and a doctor should be consulted.
Contraindications
You can not use the drug in such cases:
- sarcoidosis;
- avitaminosis K;
- portal hypertension;
- hemorrhagic diathesis;
- renal failure;
- nephrourolithiasis;
- hemophilia;
- hypoprothrombinemia;
- chronic alcoholism;
- severe hypercalciuria, hypercalcemia;
- phenylketonuria (for AnviMax in powder form);
- diseases of the thyroid gland;
- period of pregnancy and lactation;
- exacerbation of chronic liver and / or kidney disease;
- gastrointestinal bleeding;
- lactase deficiency, glucose-galactose malabsorption syndrome;
- simultaneous use of cardiac glycosides;
- children and adolescents under 18 years of age;
- exacerbation of erosive and ulcerative lesions of the gastrointestinal tract;
- hypersensitivity to the components of the drug (one or more);
- acute liver and / or kidney disease (acute hepatitis, acute pyelonephritis, acute glomerulonephritis).
Side effects
Conservative treatment with AnviMax can cause such undesirable consequences:
- urinary system: moderate pollakiuria;
- hematopoietic organs: changes in blood parameters (control is required);
- allergic reactions: urticaria, skin rash, itching;
- central nervous system: flushing of the face, hyperexcitability, drowsiness, dizziness, tremors, headache, hyperkinesia;
- digestive system: lack of appetite, dryness of the oral mucosa, damage to the mucous membrane of the duodenum and stomach, flatulence, dyspepsia, diarrhea;
- endocrine system: glucosuria, hyperglycemia (suppression of the activity of the insular apparatus of the pancreas).
If AnviMax is taken in a dosage exceeding the daily therapeutic norm, the following symptoms are observed in the first 24 hours after taking the drug: nausea, vomiting, diarrhea, pallor of the skin, pain in the stomach; arrhythmia, tachycardia, headache, acidosis, exacerbation of existing chronic diseases. After 48 hours, symptoms of liver dysfunction may appear.
Severe overdose of AnviMax can lead to acute liver failure, coma. Overdose treatment is carried out by administering acetylcysteine \u200b\u200band methionine. Gastric lavage is performed and symptomatic treatment is prescribed.
Analogs of Anvimax
Anvimax has no structural analogs for the active substance. The drug is unique in its combination of active ingredients.
However, Anvimax has a lot of medications that are similar to it in terms of indications for use and the action of the pharmacological plan, but each of them contains a different active substance in its composition. Here are just a few of them:
- Engystol in the form of tablets;
- Influenza Heel pills;
- Grippferon in the form of nasal drops;
- Bioaron C syrup for children;
- Antigrippin effervescent tablet;
- Interferon in the form of a dry substance in ampoules for the preparation of a nasal solution;
- Teraflu in the form of a powder for the preparation of a solution for a single oral administration.
Attention: the use of analogs must be agreed with the attending physician.
Prices
The average price of ANVIMAX, powder in pharmacies (Moscow) is 135 rubles.
Terms of dispensing from pharmacies
The drug is approved for use as a means of OTC.
Problems with hormones: symptoms It would seem that only test results can tell about hormonal disruptions, but there are other ways. If you carefully listen to the signals that the body gives, it is quite possible to recognize a certain one.
Indications: etiotropic treatment of influenza type A;
symptomatic treatment of colds, flu and acute respiratory viral infections, accompanied by fever, muscle pain, headache, chills.
Contraindications:
hypersensitivity to one or more of the components that make up the drug; erosive and ulcerative lesions of the gastrointestinal tract in the acute phase; gastrointestinal bleeding; hemophilia; hemorrhagic diathesis; hypoprothrombinemia; portal hypertension; avitaminosis K; renal failure; diseases of the thyroid gland; acute diseases of the kidneys, liver (acute glomerulonephritis, acute pyelonephritis, acute hepatitis or exacerbation of chronic diseases of these organs); chronic alcoholism; hypercalcemia, severe hypercalciuria; nephrourolithiasis; sarcoidosis; simultaneous intake of cardiac glycosides (risk of arrhythmias); lactose intolerance, lactase deficiency, glucose-galactose malabsorption; phenylketonuria; pregnancy; period of breastfeeding; children under 18 years of age.
Side effects:
In accordance with the constituent components.
From the side of the central nervous system: increased excitability, drowsiness, tremor, hyperkinesia, dizziness, headache, flushing of the face.
On the part of the digestive system: damage to the mucous membrane of the stomach and duodenum, dyspepsia, dryness of the oral mucosa, lack of appetite, bloating (flatulence), diarrhea (diarrhea).
From the urinary system: moderate pollakiuria.
On the part of the hematopoietic organs: changes in blood parameters (control is necessary)
Others: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glucosuria).
Allergic reactions: skin rash, itching, urticaria.
If any of these side effects have worsened or other side effects not listed in the instructions appear, you must inform your doctor as soon as possible.
Overdose:
Symptoms: during the first 24 hours after administration - pallor of the skin, nausea, diarrhea, vomiting, pain in the epigastric region; impaired glucose metabolism, metabolic acidosis, tachycardia, arrhythmia, headache, exacerbation of concomitant chronic diseases. Symptoms of liver dysfunction may appear 12–48 hours after overdose. In case of severe overdose - hepatic failure with progressive encephalopathy, coma; acute renal failure with tubular necrosis (including in the absence of severe liver damage).
Treatment: administration of donors of SH-groups and precursors of the synthesis of glutathione - methionine - within 8-9 hours after overdose and acetylcysteine \u200b\u200b- within 8 hours. Gastric lavage, symptomatic therapy. The need for additional therapeutic measures (further administration of methionine, acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time that has passed after its administration.
Method of administration and dosage:
Dissolve the contents of one sachet in half a glass of boiled warm water. Consume immediately after dissolving. Stir the solution before use.
