Dosage form

Enteric-coated tablets 100 mg and 300 mg

Composition

One tablet contains

active substance - acetylsalicylic acid 100 mg or 300 mg,

auxiliary substances: cellulose powder, corn starch, eudragit L30D, polysorbate 80, sodium lauryl sulfate, talc, triethyl citrate.

Description

Round, biconvex, slightly rough, beveled to the edge of a white tablet, at the break - a homogeneous mass of white, surrounded by a shell of the same color

Pharmacotherapeutic group

Anticoagulants. Platelet aggregation inhibitors excl. heparin. Acetylsalicylic acid

ATX code B01AC06

Pharmacological properties

Pharmacokinetics

After oral administration, acetylsalicylic acid (ASA) is rapidly and completely absorbed from the gastrointestinal tract.

During and immediately after absorption, acetylsalicylic acid is converted into the main active metabolite, salicylic acid.

The maximum concentration of acetylsalicylic acid in the blood plasma is reached after 10-20 minutes, the maximum concentration of salicylic acid - after 0.3-2 hours.

Due to the fact that the enteric coating of Aspirin Cardio® tablets is resistant to the action of acid, the release of the active substance does not occur in the stomach, but in the alkaline medium of the intestine. Due to this, the absorption of acetylsalicylic acid is delayed by 3-6 hours in comparison with non-enteric coated tablets.

Acetylsalicylic and salicylic acids bind to a significant extent with plasma proteins and are rapidly distributed in tissues.

Salicylic acid is excreted in breast milk and crosses the placental barrier.

Salicylic acid is metabolized mainly in the liver with the formation of metabolites - salicylurate, salicylophenolic glucuronide, salicylic glucuronide, gentisic and gentizuric acids.

The elimination of salicylic acid is dose-dependent.

The half-life when taking the drug in low doses is 2-3 hours, when taking the drug in high doses - 15 hours. Salicylic acid and its metabolites are excreted mainly by the kidneys.

Pharmacodynamics

The mechanism of action of acetylsalicylic acid is based on irreversible inhibition of cyclooxygenase (COX-1), as a result of which the synthesis of thromboxane A2 is blocked and platelet aggregation is suppressed. The antiplatelet effect is most pronounced in platelets, since they are not able to re-synthesize cyclooxygenase.

It is believed that acetylsalicylic acid has other mechanisms for suppressing platelet aggregation, which expands the scope of its application in various vascular diseases.

Acetylsalicylic acid belongs to the group of non-steroidal anti-inflammatory drugs, and has analgesic, antipyretic and anti-inflammatory effects.

Higher doses are used to relieve pain and minor febrile conditions such as colds and flu, to reduce fever, reduce muscle and joint pain, and for acute and chronic inflammatory diseases such as rheumatoid arthritis, osteoarthritis and ankylosing spondylitis.

Indications for use

To reduce the risk of death in patients with suspected acute myocardial infarction

To reduce the risk of morbidity and mortality in patients with myocardial infarction

For secondary prevention of stroke

To reduce the risk of developing transient ischemic attack (TIA) and stroke in patients with TIA

To reduce morbidity and mortality in stable and unstable angina

For the prevention of thromboembolism after surgery and invasive interventions on the vessels (for example, percutaneous transluminal catheter angioplasty, coronary artery bypass grafting, carotid endarterectomy, arteriovenous bypass grafting)

For the prevention of deep vein thrombosis and pulmonary embolism during prolonged immobilization (for example, after major surgery)

To reduce the risk of developing acute myocardial infarction in the presence of cardiovascular risk factors (eg, diabetes mellitus, hyperlipidemia, hypertension, obesity, smoking, old age)

Method of administration and dosage

For oral administration.

Aspirin Cardio enteric-coated tablets should be taken before meals with plenty of liquid.

To reduce the risk of death in patients with acute myocardial infarction

The initial dose of 100-300 mg (the first tablet must be chewed for faster absorption) should be taken by the patient as soon as possible after the development of acute myocardial infarction is suspected.

In the next 30 days after the development of myocardial infarction, a dose of 100-300 mg / day should be maintained.

After 30 days, the need for further therapy should be considered to prevent the development of recurrent myocardial infarction.

To reduce the risk of morbidity and mortality in patients with myocardial infarction

100-300 mg / day

For secondary prevention of stroke

100-300 mg / day

To reduce the risk of TIA and stroke in patients with TIA

100-300 mg / day

To reduce morbidity and mortality in stable and unstable angina

100-300 mg / day

For the prevention of thromboembolism after surgery and invasive interventions on the vessels

100-300 mg / day

For the prevention of deep vein thrombosis and pulmonary embolism

100-200 mg / day or 300 mg every other day

To reduce the risk of developing acute myocardial infarction

100 mg daily or 300 mg every other day.

Side effects

The side effects listed below are based on spontaneous post-marketing reports and experience with all forms of Aspirin, including oral forms for short and long courses of treatment.

Therefore, their frequency representation in accordance with the CIOMS III categories is not possible.

Dyspepsia, abdominal pain and pain in the gastrointestinal area

Inflammation of the gastrointestinal tract, ulcers of the mucous membrane of the stomach and duodenum (extremely rarely, potentially leading to gastrointestinal bleeding and perforations with corresponding clinical and laboratory symptoms)

Rarely - very rarely:

Severe cases of bleeding, such as gastrointestinal bleeding, cerebral hemorrhage (especially in patients with uncontrolled arterial hypertension and / or receiving concomitant anticoagulant therapy), which in some cases can be life-threatening.

Rarely:

Severe hypersensitivity reactions including anaphylactic shock

Transient liver dysfunctions with increased activity of "hepatic" transaminases

With an unknown frequency:

Bleeding such as perioperative bleeding, hematoma, epistaxis (epistaxis), bleeding from the genitourinary tract, bleeding gums

Hemolysis and hemolytic anemia in patients with severe glucose-6-phosphate dehydrogenase deficiency

Renal dysfunction and acute renal failure

Hypersensitivity reactions with corresponding clinical and laboratory manifestations (asthmatic syndrome, mild to moderate reactions from the skin, respiratory tract, gastrointestinal tract and cardiovascular system, including skin rash, urticaria, edema, pruritus, rhinitis, mucosal edema nasal membranes, cardio-respiratory distress syndrome)

Dizziness and ringing in the ears, which can also be a sign of drug overdose.

Contraindications

Hypersensitivity to acetylsalicylic acid or other salicylates, or to any of the excipients of the drug

History of bronchial asthma induced by the intake of salicylates and substances of similar action, in particular non-steroidal anti-inflammatory drugs (NSAIDs)

Acute period of peptic ulcer

Hemorrhagic diathesis

Severe renal failure

Severe liver failure

Severe heart failure

Combined use with methotrexate at a dose of 15 mg per week or more

The last trimester of pregnancy for Aspirin cardioÒ 100 mg (see section "Pregnancy and lactation")

Pregnancy period (all 3 trimesters) for Aspirin cardioÒ 300 mg (see section "Pregnancy and lactation")

Drug interactions

Contraindicated interactions

Methotrexate at a dose of 15 mg / week or more

With the simultaneous use of ASA with methotrexate, the hematological toxicity of methotrexate increases due to the fact that NSAIDs reduce the renal clearance of methotrexate, and salicylates, in particular, displace it from its connection with plasma proteins.

Combinations requiring caution

Ibuprofen

Ibuprofen, when used simultaneously with ASA, antagonizes its positive effect on platelets.

In patients with an increased risk of cardiovascular diseases, the simultaneous use of ibuprofen and ASA leads to a decrease in its cardioprotective effect.

Anticoagulants, thrombolytic and other antiplatelet drugs

There is a risk of bleeding.

Other NSAIDs with salicylates in a high dose (3 g / day or more)

Due to the synergism of the action, the risk of ulceration of the gastrointestinal mucosa and bleeding increases.

Selective serotonin reuptake inhibitors

Due to the synergistic action, the risk of bleeding from the upper gastrointestinal tract increases.

Digoxin

By reducing renal clearance, ASA increases the concentration of digoxin in the blood plasma.

Antidiabetic agents such as insulin, sulfonylurea derivatives

High doses of ASA enhance the effect of hypoglycemic drugs due to the hypoglycemic effect of acetylsalicylic acid and the displacement of sulfonylurea derivatives from the connection with blood plasma proteins.

Diuretics in combination with high doses of ASA

There is a decrease in glomerular filtration as a result of a decrease in the synthesis of prostaglandins in the kidneys.

Systemic glucocorticosteroids (GCS), with the exception of hydrocortisone used for replacement therapy of Addison's disease

With corticosteroid therapy, the level of concentration of salicylates in the blood decreases and there is a risk of developing an overdose of salicylates after stopping treatment, since corticosteroids increase the excretion of the latter.

Angiotensin-converting enzyme (ACE) inhibitors in combination with high doses of ASA

There is a decrease in glomerular filtration as a result of inhibition of prostaglandins, which have a vasodilating effect, respectively, a weakening of the hypotensive effect.

Valproic acid

The toxicity of valproic acid increases due to displacement from the connection with blood plasma proteins.

There is an increased risk of damage to the gastrointestinal mucosa and lengthening of bleeding time as a result of the mutual enhancement of the effects of ASA and ethanol.

Uricosuric drugs such as benzbromarone, probenecid

The uricosuric effect is reduced due to the competitive renal tubular elimination of uric acid.

special instructions

The drug should be used with caution in the following conditions:

For hypersensitivity to analgesics, anti-inflammatory, antirheumatic drugs and other types of allergies

A history of gastrointestinal ulceration, including chronic or recurrent peptic ulcer disease or gastrointestinal bleeding

When used together with anticoagulants (See section "Drug Interactions")

In patients with impaired renal or circulatory function (eg, vascular renal disease, congestive heart failure, reduced blood volume, major surgery, sepsis, or severe bleeding), as acetylsalicylic acid may further increase the risk of kidney damage or acute renal insufficiency

In patients with severe glucose-6-phosphate dehydrogenase (G6PD) deficiency, acetylsalicylic acid can induce the development of hemolysis or hemolytic anemia. Factors that can increase the risk of hemolysis include, for example, high doses of the drug, fever, or acute infections

If liver function is impaired

Ibuprofen may interfere with the inhibitory effect of ASA on platelet aggregation. Patients receiving ASA treatment and taking ibuprofen for pain relief should inform their physician.

ASA can provoke bronchospasm, as well as cause attacks of bronchial asthma and other hypersensitivity reactions. Risk factors include a history of bronchial asthma, hay fever, nasal polyposis, chronic respiratory diseases, and allergic reactions to other substances (eg, skin reactions, itching, urticaria).

Due to the inhibitory effect on platelets, the use of Aspirin Cardio may be associated with an increased risk of bleeding. Due to this ability to suppress platelet aggregation, which persists for several days after taking the drug, acetylsalicylic acid can lead to increased bleeding during and after surgical interventions (including minor surgical interventions, for example, tooth extraction).

Bleeding can lead to the development of acute or chronic posthemorrhagic / iron deficiency anemia (for example, due to latent microbleeding) with corresponding clinical and laboratory signs and symptoms such as asthenia, pallor of the skin, hypoperfusion.

ASA in low doses reduces the excretion of uric acid, which can provoke the development of gout in susceptible individuals.

Application in pediatrics

There is a relationship between taking Aspirin and the development of Reye's syndrome when used in children with certain viral diseases. The risk may be increased with the combined use of drugs containing ASA, however, a causal relationship has not been identified. The development of persistent vomiting in these conditions may be a sign of Reye's syndrome.

Reye's syndrome is a very rare disease that can cause brain and liver damage and can be fatal.

In this regard, Aspirin cardio should not be used in children and adolescents under 18 years old, except in cases of special indications.

Application during pregnancy

Inhibition of prostaglandin synthesis can have negative effects on pregnancy and embryo or fetal development. Epidemiological data indicate an increased risk of malformations and malformations with the use of inhibitors of prostaglandin synthesis in early pregnancy. In this case, it is believed that the risk increases with increasing dose and duration of treatment. The available data do not confirm any relationship between the use of acetylsalicylic acid and an increased risk of premature termination of pregnancy. The available epidemiological data regarding the development of malformations are contradictory, however, an increased risk of developing a defect - non-closure of the anterior abdominal wall cannot be excluded. Prospective use of ASA in the early period of pregnancy (1-4 months) in 14,800 women / children did not reveal any association with an increased incidence of malformations.

Preclinical data have shown reproductive toxicity. The appointment of drugs containing acetylsalicylic acid in the first and second trimesters of pregnancy is not indicated, until it is dictated by extreme necessity.

With this in mind, in the first and second trimesters of pregnancy, Aspirin Cardio at a dose of 100 mg can be used only after a doctor has carefully assessed the risk / benefit ratio.

When using drugs containing acetylsalicylic acid by a woman during conception, or in the first and second trimester of pregnancy, it is necessary to use the lowest possible dose of the drug and conduct a short course of treatment.

In the third trimester of pregnancy, all inhibitors of prostaglandin synthesis can cause the fetus:

Cardiopulmonary toxicity (with premature closure of the duct botalle and pulmonary hypertension)

Renal dysfunction, which can progress to renal failure with oligohydramnios;

In the mother and fetus at the end of pregnancy:

Possible increase in bleeding time, antiplatelet effect, which can occur even at small doses

Suppression of the contractile activity of the uterus, which can lead to prolonged delivery or prolonged labor

In this regard, ASA is contraindicated for use in the third trimester of pregnancy.

Application during lactation

Salicylates and their metabolites are excreted in breast milk in small amounts. Accidental intake of salicylates during lactation does not require termination of breastfeeding. However, if a doctor prescribes long-term use of the drug or taking acetylsalicylic acid in high doses, breastfeeding should be discontinued.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

Considering possible side effects such as dizziness, care must be taken when driving or driving potentially dangerous machinery.

Overdose

Salicylate intoxication (develops when ASA is taken at a dose of more than 100 mg / kg / day for more than 2 days) may result from prolonged use of toxic doses of the drug as a result of improper therapeutic use of the drug (chronic intoxication) or a single accidental or deliberate intake of a toxic dose of the drug an adult or a child (acute intoxication).

Chronic overdose symptoms are nonspecific and often difficult to diagnose.

Chronic overdose of mild severity usually develops only after repeated use of large doses of the drug.

Symptoms: dizziness, tinnitus, hearing loss, increased sweating, nausea and vomiting, headache and confusion. These symptoms disappear after reducing the dose of the drug. Tinnitus can appear when the concentration of ASA in blood plasma is from 150 to 300 μg / ml. More severe symptoms appear when the ASA concentration is more than 300 μg / ml.

Acute intoxication

Symptoms: the main manifestation of acute intoxication is a severe violation of the acid-base state, the manifestations of which can vary depending on the age of the patient and the severity of intoxication. In children, the development of metabolic acidosis is most typical. The severity of intoxication cannot be assessed only by the concentration of ASA in the blood plasma. Absorption of ASA can be delayed due to delayed gastric emptying, the formation of calculi in the stomach, or as a result of taking enteric-coated tablets.

Treatment: is carried out in accordance with accepted standards and depends on the severity of intoxication and the clinical picture and should be aimed mainly at accelerating the elimination of the drug and restoring the water-electrolyte balance and acid-base state.

Mild to moderate overdose

Symptoms: tachypnea, hyperventilation, respiratory alkalosis (alkalemia and alkaluria), increased sweating, nausea and vomiting.

Treatment: gastric lavage, repeated intake of activated carbon, forced diuresis with drugs for alkalizing urine, restoration of water-electrolyte balance and acid-base state.

Moderate to severe overdose

Symptoms:

Respiratory alkalosis with compensatory metabolic acidosis (acidemia and aciduria)

Hyperpyrexia

Respiratory disorders: hyperventilation, noncardiogenic pulmonary edema, respiratory depression, asphyxia

Violations of the cardiovascular system: heart rhythm disturbances, arterial hypotension, inhibition of cardiac activity (changes in blood pressure, electrocardiogram)

Water and electrolyte imbalance: dehydration, impaired renal function from oliguria up to the development of renal failure (hypokalemia, hypernatremia, hyponatremia)

Impaired glucose metabolism: hyperglycemia, hypoglycemia (especially in children), ketoacidosis

Tinnitus, deafness

Gastrointestinal bleeding

Hematological disorders: from inhibition of platelet aggregation to coagulopathy, prolongation of prothrombin time, hypoprothrombinemia

Neurological disorders: toxic encephalopathy and depression of the central nervous system (drowsiness, confusion, coma, convulsions)

Treatment: immediate hospitalization in specialized departments for emergency therapy - gastric lavage, repeated intake of activated carbon, forced alkaline diuresis, hemodialysis.

Restoration of water-electrolyte balance and acid-base state, symptomatic therapy.

Latin name:Aspirin ® Cardio
ATX code: B01FC06
Active substance: acid acetylsalicylic
Manufacturer:Beeterfield (Switzerland)
Pharmacy dispensing condition: Without recipe

According to the World Health Organization, diseases of the heart and blood vessels rank first among all known pathologies. In order to prevent strokes and heart attacks, many drugs have been created, one of which is the cardiac Aspirin Cardio or Cardiomagnet - its analogue. Both drugs are actively used in cardiological practice, produced by a foreign manufacturer and have almost the same list of indications. In addition, the main active ingredient of both drugs is acetylsalicylic acid. This substance has aggregate, antipyretic and analgesic properties.

Indications

The anti-inflammatory drug Aspirin Cardio is intended for the prevention and treatment of a number of diseases related to cardiology:

• Strokes
• Myocardial infarction
• Violation of cerebral circulation
• Thromboembolism
• Obesity
• Diabetes
• Hyperlipidemia
• Before and after surgical interventions on blood vessels and heart
• Ischemic attacks
• Arterial hypertension
• Patient's advanced age and weakened heart
• To reduce the risk of death in patients who have had a heart attack or stroke
• Arthritis
• Respiratory and colds.

Composition

The imported drug is produced in solid form, contains one aspirin tablet as the main active ingredient and several auxiliary components:

• Methacrylic acid ester - emulsifier and copolymer
• Oxyethylated non-ionic sorbitan - fat solubilizer
• Cellulose, talc and starch are the elements needed to solidify the drug
• Triethyl citrate blowing agent of natural origin
• Sodium dodecyl sulfate - lysis buffer.

Patients suffering from diseases of the heart and blood vessels or having a large body weight and taking different means to prevent pathologies often ask the question: Aspirin Cardio and Cardiomagnyl, what is the difference. The difference between these medicines is that the latter, in addition to all similar components, also contains magnesium hydroxide. But both drugs belong to the group of non-steroidal anti-inflammatory substances.

Pharmacological properties

The drug is intended for oral administration. Once in the digestive system, it is converted to acetylsalicylic acid. Aspirin for the heart plays the role of an analgesic, it relieves fever, eliminates inflammation. This element was first synthesized back in the 19th century, and only 50 years later chemists discovered its new properties.

Studies of the element have shown that it is effective for the treatment of cardiac and vascular pathologies, since acetylsalicylic acid cardio is able to suppress the production of platelet compounds. It acts as an inhibitor of cyclooxygenase, a substance that advises the action of prostaglandins and thromboxanes.

The aspirin molecule contains acetic and salicylic acid. Since a blood clot forms at the site of damage to the vessel, the walls become prone to adhesion. The expansion process involves prostacyclin, which is produced simultaneously with thromboxane. When the balance in synthesis between these elements is disturbed, blood flow slows down, which can lead to heart damage. The acids in Cardio Aspirin 100 prevent a negative process and prevent blockages from forming.

The use of the drug gives a good antipyretic effect, helps to eliminate fever, relieve rheumatic pain syndrome. Since the element reduces the production of hyaluronidase, it is able to remove inflammation. Also, aspirin is responsible for capillary permeability, reduces their fragility, inactivates the functions of prostaglandins. Due to this, more adenosine triphosphate can be produced, which uses energy resources to help the acid.

The tool affects the centers of thermoregulation located in the hypothalamus. Thus, it reduces high fever, relieves a person of the heat and chills that accompany respiratory diseases and manifestations of arthritis and rheumatism. The peptide that causes pain, bradykinin, on the one hand, has a positive effect, dilating blood vessels. But on the other hand, it acts as a plasma algogen that acts on nerve receptors and increases sensitivity.

It also releases prostacyclin, a metabolite of arachidic acid, which prevents blood clots. This dual action selectively regulates acetylsalicylic acid, allowing the substance to participate in processes that prevent the formation of blockages, but prevent the possibility of signaling to pain receptors. Thus, the analgesic properties of the drug are provided. Thanks to blood-thinning functions, intracranial pressure decreases, which is an exhaustive answer to the question of what the remedy helps from.

The maximum concentration of the composition is created 20 minutes after ingestion. Since the drug is produced in a shell, it begins to dissolve in the intestine without negatively affecting the gastric mucosa. When prescribing, the doctor will explain how to take it correctly and when you can take the pills. The medication is excreted through the kidneys, after 2-15 hours, depending on the dosage.

Although aspirin is a well-studied compound, drug development is one of the most costly and challenging areas in pharmacology research. In this case, all factors should be taken into account: the optimal combination of different elements, their interaction and effect on the body, side reactions and the degree of toxicity. Thanks to IT technologies, digital tools have appeared that allow you to create new drugs more productively and in a short time and shorten the testing period. Now all data is analyzed not in the traditional way, but on the basis of the Microsoft cloud platform. Therefore, improved means, such as Aspirin Cardiomagnet or Thrombo Ass, are highly effective.

Release forms

Cost: tab. 100 mg No. 28 - 150-200 rubles. No. 56 - 270-300 rubles. 300 mg No. 20 - 85-90 rubles.

The drug is produced only in tablet form. Unit weight - 100 or 300 mg. The shell is glossy, smooth, without impurities. Color - white, no smell. They can be swallowed whole, and when chewed, they taste bitter and sour. The tablets are packed in polyethylene-paper strips or aluminized blisters with a transparent surface. In a white-blue pack with a red stripe there are 20, 28 or 56 pieces and Aspirin Cardio instructions for use. The price is quite reasonable.

Application methods

For the prevention of diseases of the heart and blood vessels, rheumatic pathologies, you can take 100 mg per day without violating the treatment regimen. For therapeutic purposes, it is recommended to use the agent at 100-300 mg per day, depending on the patient's condition. The duration of the course of treatment is a month. If necessary, it can be extended, but only after a two-week break.

It is better to take the drug in its entirety, half an hour after a meal, with plenty of liquid, which will reduce its negative effect on the mucous membranes of the digestive system. Chewing the product is allowed only in extreme cases, for example, with unstable angina. It is not recommended to give medication to children with fever during acute manifestations of a cold, as it can worsen the condition.

Application during pregnancy

Since the composition easily passes through all barriers, including the placental one without difficulty, it is contraindicated in the 1st and 3rd semester. During the second semester, the medicine is prescribed only after realistically assessing the ratio of the therapeutic effect for the mother and the possible danger to the development of the fetus. At the time of lactation, you can not take the drug or stop breastfeeding for the entire period of therapy.

Contraindications

The pharmaceutical agent is not prescribed for the following diseases and conditions:

• Aspirin-type asthma syndrome
• Acute heart failure
• Diathesis
• Allergic manifestations
• Severe pathologies of the liver and kidneys
• Intolerance to components.

Despite the fact that the drug is produced in a shell, its effect on the mucous membrane is minimal, with ulcerative lesions, gastritis and colitis, care must be taken.

Combination with other formulations

Since aspirin can enhance the effect of some drugs and minimize the effects of others, a doctor's consultation is necessary to determine interactions. It should be borne in mind that while taking acetylsalicylic acid can manifest itself in different ways:

• The composition enhances the properties of anticoagulants, thrombolytics and antiplatelet agents
• When using hypoglycemic medications, patients with diabetes need to control hormone levels
• The action of diuretics is weakened
• Systemic corticosteroids and anti-inflammatories reduce the function of aspirin
• When interacting with other medicines containing a similar active element, bleeding may increase after surgery.

Side effects

The information is based on data on negative reactions after taking all groups of drugs containing aspirin:

• From the side of digestion: dyspeptic disorders, gag reflex, nausea. Epigastric pain and erosive lesions. In rare cases, hemorrhages and mucosal perforation.
• The risk of bleeding from the nose, gums and after surgery. Especially the danger increases for patients with uncontrolled arterial hypertension and for people taking antihemostatics.
• Asthenia, iron deficiency anemia, hypoperfusion.
• Impaired renal function.
• Asthmatic condition and respiratory failure.
• Skin manifestations in the form of rash and redness.

Overdose

An excess of the amount, mainly entails an increase in side effects. Possible toxic effects of salicylates due to chronic intoxication. Manifestations are latent with moderate overdose. In other cases, the symptoms are expressed in tinnitus, acid and alkaline imbalance. Some patients have had metabolic acidosis and calculus formation. Therapy is based on the clinical picture, determined by the severity, is to eliminate signs of poisoning and restore the electrolyte balance. The patient's condition is stabilized, after which he is transferred to supportive and restorative treatment regimens.

Storage rules

The product is suitable for use for 5 years. Avoid exposure to light and moisture. Access to children should be limited.

Analogs

Manufacturers offer a group of drugs with aspirin as the main active ingredient. This list includes the following medicines:

Cardiomagnet

Manufacturer: Nycomed (Denmark)

Cost: 75 mg No. 30 - 130-150 rubles. No. 100 - 250-300 rubles. 150 mg No. 100 - 400-430 rubles.

The composition of the drug includes acetylsalicylic acid and magnesium hydroxide. According to the principle of influence on the body, it does not differ from analogues, therefore only a doctor can decide which is better, Aspirin Cardio or Cardiomagnet. The remedy relieves pain, lowers the temperature, helps with fever and chills. The main active element inhibits the synthesis of cyclooxygenases, thereby preventing the formation of platelets. Which has a positive effect on the rheological characteristics of the blood. The magnesium contained in the preparation is intended to prevent the irritating effect of aspirin on the stomach lining.

The composition is absorbed in full, reaching maximum concentrations three hours after ingestion. Bioavailability can reach almost 95%. A medication is prescribed for chronic ischemic syndrome, heart failure, unstable angina pectoris. Suitable for the prevention of obesity in diabetes, thrombus formation, therapy of arterial hypertension. Contraindicated in ulcerative peptic lesions, cardiac decompensation, status asthmaticus.

It goes on sale in a tablet form made in the form of white hearts. Each unit has a dividing strip. The medicine is packed in opaque brown glass jars with a polypropylene lid, 30 or 100 pieces each. There is no smell, the taste is specific when biting. The dosage for treatment is 75 mg per day, for prophylactic purposes - 150-450 mg per day, depending on the purpose and condition of the patient. The course of therapy is determined by the doctor, but for some patients, the duration of admission may be lifelong.

Advantages:

• Acceptable price
• The drug relieves acute symptoms of cardiac and vascular dysfunctions.

Disadvantages:

• The composition is prohibited for use by children.
• There is a long list of adverse reactions.

Manufacturer: Lannacher (Austria)

Cost: tab. 50 mg No. 28 - 45-50 rubles. No. 100 - 150-170 rubles.

A drug characterized by fibrinolytic plasma activity and reducing blood coagulation factors. The main active ingredient of Thrombo Ass is aspirin. Antiplatelet properties develop slowly, at small doses. The composition eliminates pain syndrome, removes the feeling of heaviness in the lower extremities, relieves heat and inflammation. Once in the body, the drug releases acids that most actively bind to proteins. Thanks to this, thrombus formation is prevented, capillary permeability is controlled. Damaged vessels regenerate faster, and the sticking effect stops.

The medicine is indicated for varicose veins, heart attacks, ischemic status, thromboembolism. It helps with angina pectoris, prevents the development of repeated strokes. Controls blood pressure and heart activity. It is forbidden to prescribe the composition for polliposis in the nasal sinuses, hemorrhagic diathesis, aspirin asthma. It is given with caution to patients with impaired rheology and a tendency to bleeding. There is a long list of side effects. In addition, the drug is not combined with some formulations, so consultation with a cardiologist or therapist is required.

The medication goes on sale in metallized blisters with an opaque matte surface, in which round white tablets are packed. It is recommended to swallow them with plenty of water, at least an hour after eating. If necessary, the product can be bitten or chewed, ground into powder, but provided that there are no problems with the digestive system. A slight sour taste with bitterness will appear, but it is insignificant. The average dosage is 50-100 mg per day. The duration of therapy is determined based on diagnosis.

Advantages:

• Relieves pain with varicose veins
• Helps with vascular blockage.

Disadvantages:

• Available in only one form
• Forbidden for children and pregnant women.

INN: Acetylsalicylic acid

Manufacturer: Bayer Pharma AG

Anatomical-therapeutic-chemical classification: Acetylsalicylic acid

Registration number in the RK: No. RK-LS-5 No. 013404

Registration period: 13.03.2019 - 13.03.2029

KNF (drugs are included in the Kazakhstan National Formulary of Medicines)

ALO (Included in the List of Free Outpatient Drug Provision)

UNIT (Included in the List of Medicines under the guaranteed volume of medical care to be purchased from a Single Distributor)

Maximum purchase price in the Republic of Kazakhstan: 7.35 KZT

Instructions

Tradename

Aspirin cardio

International non-proprietary name

Acetylsalicylic acid

Dosage form

Enteric-coated tablets 100 mg and 300 mg

Composition

One tablet contains

active substance - acetylsalicylic acid 100 mg or 300 mg,

excipients: cellulose powder, corn starch, eudragit L30D, polysorbate 80, sodium lauryl sulfate, talc, triethyl citrate.

Description

Round, biconvex, slightly rough, beveled to the edge of a white tablet, at the break - a homogeneous mass of white, surrounded by a shell of the same color

Pharmacotherapeutic group

Anticoagulants. Platelet aggregation inhibitors excl. heparin. Acetylsalicylic acid

ATX code B01AC06

Pharmacological properties

Pharmacokinetics

After oral administration, acetylsalicylic acid (ASA) is rapidly and completely absorbed from the gastrointestinal tract.

During and immediately after absorption, acetylsalicylic acid is converted into the main active metabolite, salicylic acid.

The maximum concentration of acetylsalicylic acid in the blood plasma is reached after 10-20 minutes, the maximum concentration of salicylic acid - after 0.3-2 hours.

Due to the fact that the enteric coating of Aspirin Cardio® tablets is resistant to the action of acid, the release of the active substance does not occur in the stomach, but in the alkaline medium of the intestine. Due to this, the absorption of acetylsalicylic acid is delayed by 3-6 hours in comparison with non-enteric coated tablets.

Acetylsalicylic and salicylic acids bind to a significant extent with plasma proteins and are rapidly distributed in tissues.

Salicylic acid is excreted in breast milk and crosses the placental barrier.

Salicylic acid is metabolized mainly in the liver with the formation of metabolites - salicylurate, salicylophenolic glucuronide, salicylic glucuronide, gentisic and gentizuric acids.

The elimination of salicylic acid is dose-dependent.

The half-life when taking the drug in low doses is 2-3 hours, when taking the drug in high doses - 15 hours. Salicylic acid and its metabolites are excreted mainly by the kidneys.

Pharmacodynamics

The mechanism of action of acetylsalicylic acid is based on irreversible inhibition of cyclooxygenase (COX-1), as a result of which the synthesis of thromboxane A2 is blocked and platelet aggregation is suppressed. The antiplatelet effect is most pronounced in platelets, since they are not able to re-synthesize cyclooxygenase.

It is believed that acetylsalicylic acid has other mechanisms for suppressing platelet aggregation, which expands the scope of its application in various vascular diseases.

Acetylsalicylic acid belongs to the group of non-steroidal anti-inflammatory drugs, and has analgesic, antipyretic and anti-inflammatory effects.

Higher doses are used to relieve pain and minor febrile conditions such as colds and flu, to reduce fever, reduce muscle and joint pain, and for acute and chronic inflammatory diseases such as rheumatoid arthritis, osteoarthritis and ankylosing spondylitis.

Indications for use

To reduce the risk of death in patients with suspected acute myocardial infarction

To reduce the risk of morbidity and mortality in patients with myocardial infarction

For secondary prevention of stroke

To reduce the risk of developing transient ischemic attack (TIA) and stroke in patients with TIA

To reduce morbidity and mortality in stable and unstable angina

For the prevention of thromboembolism after surgery and invasive interventions on the vessels (for example, percutaneous transluminal catheter angioplasty, coronary artery bypass grafting, carotid endarterectomy, arteriovenous bypass grafting)

For the prevention of deep vein thrombosis and pulmonary embolism during prolonged immobilization (for example, after major surgery)

To reduce the risk of developing acute myocardial infarction in the presence of cardiovascular risk factors (eg, diabetes mellitus, hyperlipidemia, hypertension, obesity, smoking, old age)

Method of administration and dosage

For oral administration.

Aspirin Cardio enteric-coated tablets should be taken before meals with plenty of liquid.

To reduce the risk of death in patients with acute myocardial infarction

The initial dose of 100-300 mg (the first tablet must be chewed for faster absorption) should be taken by the patient as soon as possible after the development of acute myocardial infarction is suspected.

In the next 30 days after the development of myocardial infarction, a dose of 100-300 mg / day should be maintained.

After 30 days, the need for further therapy should be considered to prevent the development of recurrent myocardial infarction.

To reduce the risk of morbidity and mortality in patients with myocardial infarction

100-300 mg / day

For secondary prevention of stroke

100-300 mg / day

To reduce the risk of TIA and stroke in patients with TIA

100-300 mg / day

To reduce morbidity and mortality in stable and unstable angina

100-300 mg / day

For the prevention of thromboembolism after surgery and invasive interventions on the vessels

100-300 mg / day

For the prevention of deep vein thrombosis and pulmonary embolism

100-200 mg / day or 300 mg every other day

To reduce the risk of developing acute myocardial infarction

100 mg daily or 300 mg every other day.

Side effects

The side effects listed below are based on spontaneous post-marketing reports and experience with all forms of Aspirin, including oral forms for short and long courses of treatment.

Therefore, their frequency representation in accordance with the CIOMS III categories is not possible.

Often:

Dyspepsia, abdominal pain and pain in the gastrointestinal area

Seldom:

Inflammation of the gastrointestinal tract, ulcers of the mucous membrane of the stomach and duodenum (extremely rarely, potentially leading to gastrointestinal bleeding and perforations with corresponding clinical and laboratory symptoms)

Rarely - very rarely:

Severe cases of bleeding, such as gastrointestinal bleeding, cerebral hemorrhage (especially in patients with uncontrolled arterial hypertension and / or receiving concomitant anticoagulant therapy), which in some cases can be life-threatening.

Rarely:

Severe hypersensitivity reactions including anaphylactic shock

Transient liver dysfunctions with increased activity of "hepatic" transaminases

With an unknown frequency:

Bleeding such as perioperative bleeding, hematoma, epistaxis (epistaxis), bleeding from the genitourinary tract, bleeding gums

Hemolysis and hemolytic anemia in patients with severe glucose-6-phosphate dehydrogenase deficiency

Renal dysfunction and acute renal failure

Hypersensitivity reactions with corresponding clinical and laboratory manifestations (asthmatic syndrome, mild to moderate reactions from the skin, respiratory tract, gastrointestinal tract and cardiovascular system, including skin rash, urticaria, edema, pruritus, rhinitis, mucosal edema nasal membranes, cardio-respiratory distress syndrome)

Dizziness and ringing in the ears, which can also be a sign of drug overdose.

Contraindications

- hypersensitivity to acetylsalicylic acid or other salicylates, or to any of the excipients of the drug

History of bronchial asthma induced by the intake of salicylates and substances of similar action, in particular non-steroidal anti-inflammatory drugs (NSAIDs)

Acute period of peptic ulcer

Hemorrhagic diathesis

Severe renal failure

Severe liver failure

Severe heart failure

Combined use with methotrexate at a dose of 15 mg per week or more

Last Trimester of Pregnancy for Aspirin Cardio  100 mg (see section "Pregnancy and lactation")

Pregnancy period (all 3 trimesters) for Aspirin Cardio  300 mg (see section "Pregnancy and lactation")

Drug interactions

Contraindicated interactions

Methotrexate at a dose of 15 mg / week or more

With the simultaneous use of ASA with methotrexate, the hematological toxicity of methotrexate increases due to the fact that NSAIDs reduce the renal clearance of methotrexate, and salicylates, in particular, displace it from its connection with plasma proteins.

Combinations requiring caution

Ibuprofen

Ibuprofen, when used simultaneously with ASA, antagonizes its positive effect on platelets.

In patients with an increased risk of cardiovascular diseases, the simultaneous use of ibuprofen and ASA leads to a decrease in its cardioprotective effect.

Anticoagulants, thrombolytic and other antiplatelet drugs

There is a risk of bleeding.

Other NSAIDs with salicylates in a high dose (3 g / day or more)

Due to the synergism of the action, the risk of ulceration of the gastrointestinal mucosa and bleeding increases.

Selective serotonin reuptake inhibitors

Due to the synergistic action, the risk of bleeding from the upper gastrointestinal tract increases.

Digoxin

By reducing renal clearance, ASA increases the concentration of digoxin in the blood plasma.

Antidiabetic drugs such as insulin, sulfonylurea derivatives

High doses of ASA enhance the effect of hypoglycemic drugs due to the hypoglycemic effect of acetylsalicylic acid and the displacement of sulfonylurea derivatives from the connection with blood plasma proteins.

Diuretics in combination with high doses of ASA

There is a decrease in glomerular filtration as a result of a decrease in the synthesis of prostaglandins in the kidneys.

Systemic glucocorticosteroids (GCS), with the exception of hydrocortisone used for replacement therapy of Addison's disease

With corticosteroid therapy, the level of concentration of salicylates in the blood decreases and there is a risk of developing an overdose of salicylates after stopping treatment, since corticosteroids increase the excretion of the latter.

Angiotensin-converting enzyme (ACE) inhibitors in combination with high doses of ASA

There is a decrease in glomerular filtration as a result of inhibition of prostaglandins, which have a vasodilating effect, respectively, a weakening of the hypotensive effect.

Valproic acid

The toxicity of valproic acid increases due to displacement from the connection with blood plasma proteins.

Ethanol

There is an increased risk of damage to the gastrointestinal mucosa and lengthening of bleeding time as a result of the mutual enhancement of the effects of ASA and ethanol.

Uricosuric drugs such as benzbromarone, probenecid

The uricosuric effect is reduced due to the competitive renal tubular elimination of uric acid.

special instructions

The drug should be used with caution in the following conditions:

For hypersensitivity to analgesics, anti-inflammatory, antirheumatic drugs and other types of allergies

A history of gastrointestinal ulceration, including chronic or recurrent peptic ulcer disease or gastrointestinal bleeding

When used together with anticoagulants (See section "Drug Interactions")

In patients with impaired renal or circulatory function (eg, vascular renal disease, congestive heart failure, reduced blood volume, major surgery, sepsis, or severe bleeding), as acetylsalicylic acid may further increase the risk of kidney damage or acute renal insufficiency

In patients with severe glucose-6-phosphate dehydrogenase (G6PD) deficiency, acetylsalicylic acid can induce the development of hemolysis or hemolytic anemia. Factors that can increase the risk of hemolysis include, for example, high doses of the drug, fever, or acute infections

If liver function is impaired

Ibuprofen may interfere with the inhibitory effect of ASA on platelet aggregation. Patients receiving ASA treatment and taking ibuprofen for pain relief should inform their physician.

ASA can provoke bronchospasm, as well as cause attacks of bronchial asthma and other hypersensitivity reactions. Risk factors include a history of bronchial asthma, hay fever, nasal polyposis, chronic respiratory diseases, and allergic reactions to other substances (eg, skin reactions, itching, urticaria).

Due to the inhibitory effect on platelets, the use of Aspirin cardio  may be associated with an increased risk of bleeding. Due to this ability to suppress platelet aggregation, which persists for several days after taking the drug, acetylsalicylic acid can lead to increased bleeding during and after surgical interventions (including minor surgical interventions, for example, tooth extraction).

Bleeding can lead to the development of acute or chronic posthemorrhagic / iron deficiency anemia (for example, due to latent microbleeding) with corresponding clinical and laboratory signs and symptoms such as asthenia, pallor of the skin, hypoperfusion.

ASA in low doses reduces the excretion of uric acid, which can provoke the development of gout in susceptible individuals.

Application in pediatrics

There is a relationship between taking Aspirin and the development of Reye's syndrome when used in children with certain viral diseases. The risk may be increased with the combined use of drugs containing ASA, however, a causal relationship has not been identified. The development of persistent vomiting in these conditions may be a sign of Reye's syndrome.

Reye's syndrome is a very rare disease that can cause brain and liver damage and can be fatal.

In this regard, Aspirin cardio  should not be used in children and adolescents under the age of 18, except in cases of special indications.

Application during pregnancy

Inhibition of prostaglandin synthesis can have negative effects on pregnancy and embryo or fetal development. Epidemiological data indicate an increased risk of malformations and malformations with the use of prostaglandin synthesis inhibitors in early pregnancy. In this case, it is believed that the risk increases with increasing dose and duration of treatment. The available data do not confirm any relationship between the use of acetylsalicylic acid and an increased risk of premature termination of pregnancy. The available epidemiological data regarding the development of malformations are contradictory, however, an increased risk of developing a defect - non-closure of the anterior abdominal wall cannot be excluded. Prospective use of ASA in the early period of pregnancy (1-4 months) in 14,800 women / children did not reveal any association with an increased incidence of malformations.

Preclinical data have shown reproductive toxicity. The appointment of drugs containing acetylsalicylic acid in the first and second trimesters of pregnancy is not indicated, until it is dictated by extreme necessity.

With this in mind, in the first and second trimesters of pregnancy Aspirin cardio in a dose of 100 mg can be used only after a doctor has carefully evaluated the risk / benefit ratio.

When using drugs containing acetylsalicylic acid by a woman during conception, or in the first and second trimester of pregnancy, it is necessary to use the lowest possible dose of the drug and conduct a short course of treatment.

In the third trimester of pregnancy, all inhibitors of prostaglandin synthesis can cause the fetus:

cardiopulmonary toxicity (with premature closure of the botalloid duct and pulmonary hypertension)

renal dysfunction, which can progress to renal failure with oligohydramnios;

In the mother and fetus at the end of pregnancy:

possible prolongation of bleeding time, antiplatelet effect, which can occur even with small doses

suppression of the contractile activity of the uterus, which can lead to overmaturity or prolonged labor

In this regard, ASA is contraindicated for use in the third trimester of pregnancy.

Application during lactation

Salicylates and their metabolites are excreted in breast milk in small amounts. Accidental intake of salicylates during lactation does not require termination of breastfeeding. However, if a doctor prescribes long-term use of the drug or taking acetylsalicylic acid in high doses, breastfeeding should be discontinued.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

Considering possible side effects such as dizziness, care must be taken when driving or driving potentially dangerous machinery.

Overdose

Salicylate intoxication (develops when ASA is taken at a dose of more than 100 mg / kg / day for more than 2 days) may result from prolonged use of toxic doses of the drug as a result of improper therapeutic use of the drug (chronic intoxication) or a single accidental or deliberate intake of a toxic dose of the drug an adult or a child (acute intoxication).

Chronic overdose symptoms are nonspecific and often difficult to diagnose.

Chronic overdose of mild severity usually develops only after repeated use of large doses of the drug.

Symptoms:dizziness, tinnitus, hearing loss, increased sweating, nausea and vomiting, headache and confusion. These symptoms disappear after reducing the dose of the drug. Tinnitus can appear when the concentration of ASA in blood plasma is from 150 to 300 μg / ml. More severe symptoms appear when the ASA concentration is more than 300 μg / ml.

Acute intoxication

Symptoms: othe main manifestation of acute intoxication is a severe violation of the acid-base state, the manifestations of which can vary depending on the age of the patient and the severity of intoxication. In children, the development of metabolic acidosis is most typical. The severity of intoxication cannot be assessed only by the concentration of ASA in the blood plasma. Absorption of ASA may be delayed due to delayed gastric emptying, the formation of calculi in the stomach, or as a result of taking enteric-coated tablets.

Treatment:is carried out in accordance with accepted standards and depends on the severity of intoxication and the clinical picture and should be aimed mainly at accelerating the elimination of the drug and restoring the water-electrolyte balance and acid-base state.

Mild to moderate overdose

Symptoms:tachypnea, hyperventilation, respiratory alkalosis (alkalemia and alkaluria), increased sweating, nausea and vomiting.

Treatment: gastric lavage, repeated intake of activated carbon, forced diuresis with drugs for urine alkalization, restoration of water-electrolyte balance and acid-base state.

Moderate to severe overdose

Symptoms:

Respiratory alkalosis with compensatory metabolic acidosis (acidemia and aciduria)

Hyperpyrexia

Respiratory disorders: hyperventilation, noncardiogenic pulmonary edema, respiratory depression, asphyxia

Violations of the cardiovascular system: heart rhythm disturbances, arterial hypotension, inhibition of cardiac activity (changes in blood pressure, electrocardiogram)

Water and electrolyte imbalance: dehydration, impaired renal function from oliguria up to the development of renal failure (hypokalemia, hypernatremia, hyponatremia)

Impaired glucose metabolism: hyperglycemia, hypoglycemia (especially in children), ketoacidosis

Tinnitus, deafness

Gastrointestinal bleeding

Hematological disorders: from inhibition of platelet aggregation to coagulopathy, prolongation of prothrombin time, hypoprothrombinemia

Neurological disorders: toxic encephalopathy and depression of the central nervous system (drowsiness, confusion, coma, convulsions)

Treatment: immediate hospitalization in specialized departments for emergency therapy - gastric lavage, repeated intake of activated carbon, forced alkaline diuresis, hemodialysis.

Restoration of water-electrolyte balance and acid-base state, symptomatic therapy.

Release form and packaging

On 14 or 10 tablets in a blister strip packaging made of polypropylene film and aluminum foil.

2 blister packs containing 14 tablets or 3 blister packs containing 10 tablets are placed in a cardboard box along with instructions for use.

Storage period

5 years Do not use after the expiration date.

Storage conditions

Store at a temperature not exceeding 25С.

Keep out of the reach of children!

Vacation conditions Without prescription

Manufacturer

Bayer Pharma AG, Leverkusen, Germany

Marketing Authorization Holder

Bayer Pharma AG, Berlin, Germany

Packer

Bayer Bitterfeld GmbH, Germany

The address of the organization hosting on the territory of the Republic of Kazakhstan

claims from consumers for the quality of the product (goods)

Bayer KAZ LLP, st. Timiryazeva, 42,

business center "Expo-City", pav. fifteen

050057 Almaty, Republic of Kazakhstan,

tel. +7 727 258 80 40,

fax: +7 727 258 80 39, e-mail: [email protected]

Attached files

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Content

Many patients who are prescribed cardiac aspirin are dismissive of this medicine, believing that it is unlikely to help with their diseases, because aspirin in the shell, according to general ideas, can only relieve headaches and help at high temperatures. However, cardiologists prescribe Aspirin Cardio for arterial hypertension, hypertension, in order to improve the functioning of the heart by clearing blood vessels from blood clots and plaques, therefore it is important to follow the recommendations of the attending physician when he prescribes taking aspirin for the heart.

Aspirin Cardio - instructions for use

Aspirin in the membranes is based on acetylsalicylic acid, which inhibits the synthesis of prostaglandin enzymes. Prostaglandins are involved in the inflammatory process, responsible for platelet production. Under the action of salicylate, platelets lose their ability to aggregate and coagulate, cease to stick together in the bloodstream, forming blood clots. This mechanism of action of Aspirin Cardio determines the use of this drug as an antiplatelet and anticoagulant drug.

Composition

Aspirin from the heart contains acetylsalicylic acid as the main active ingredient. So that the medicine does not corrode the gastric mucosa when taken, the tablets of the drug are coated with a membrane that dissolves only when absorbed by the intestines. Aspirin in the shell contains the following auxiliary components:

• fine crystalline cellulose powder;
• corn starch.

The shell that protects the stomach from the negative effects of the main element of the medication contains the following substances:

• a joint polymer of ethyl acrylate and methacrylic acid;
• sodium lauryl sulfate;
• talc;
• triethyl citrate;
• polysorbate.

Release form

The pharmaceutical industry produces medication in the form of tablets. Each of them can contain 100 mg or 300 mg of acetylsalicylic acid. The tablets are round in shape, convex on both sides, if you cut them, you can see that there is a white fine-crystalline substance inside, surrounded on all sides by a white shell. A blister can contain 10 or 14 pieces of tablets packed in a cardboard box. It is accompanied by instructions for use, which must be read before taking cardiac aspirin for the absence of contraindications.

Aspirin Cardio - indications for use

If the results of analyzes and examinations of the patient demonstrate a tendency to thrombosis, which can pose a danger to the health and life of the patient, then doctors must prescribe Aspirin Cardio to receive. The list of ailments for which the drug is used is extensive:

• Initial preventive measures to prevent the development of myocardial infarction in the presence of aggravating factors (type 1 or 2 diabetes mellitus, obesity, pathologically elevated blood lipids, arterial hypertension, old age, tobacco smoking, a history of primary myocardial infarction).
• Fixed unstable angina pectoris, threatening with exacerbation of ischemic heart disease and heart attack.
• Stable angina pectoris, when the patient complains of chronic attacks of pain under the scapula or behind the sternum, high blood pressure.
• Preventive measures to prevent stroke, if the patient has a lack of oxygen supply to the brain.
• Acute cerebral ischemia, threatening a stroke, which can be avoided with timely treatment.
• Prevention of blood clots after invasive surgical intervention associated with vessels (with coronary bypass grafting, stenting and angioplasty of the aorta, arteries, veins, endarterectomy and angioplasty of the carotid arteries).
• Prevention of the development of thrombosis and thromboembolism of the pulmonary artery and deep veins in conditions of prolonged immobility and bed rest of the patient after extensive abdominal surgery.

Contraindications

The medicine has an impressive list of contraindications, it is imperative that you familiarize yourself with it in order to know that the cardio drug will not harm your health when taken. Aspirin for the heart should not be taken for the following ailments:

• developed as a result of taking other NSAIDs, bronchial asthma, complicated by polyps in the nose;
• intolerance to acetylsalicylic acid, allergy to other components of aspirin;
• exacerbation of stomach and duodenal ulcers, bleeding;
• hemophilic hereditary or acquired diseases, hemorrhagic diathesis;
• pregnancy in the first and last trimester, lactation;
• age up to 15 years;
• dysfunction of the liver or kidneys, expressed in insufficient work of organs;
• failure of the heart muscle in the stage of decompensation;
• joint administration of the drug with Methotrexate, if the dosage of the latter exceeds 15 mg per week.

Method of administration and dosage

Many patients do not know how to take Aspirin Cardio correctly, and stop taking the medication when they feel better. The use of the drug is calculated for up to 1 month. Depending on the ailments the patient suffers from, the dose and frequency of taking salicylate is as follows:

• in the prevention of initial myocardial infarction - every other day, 1 tablet of 100 or 300 mg;
• for the prevention of secondary myocardial infarction, with suspected stroke and impaired blood supply to the brain - every day 1 tablet of 100 or 300 mg;
• with unstable angina pectoris - chew 1 tablet, the faster the better, to prevent the development of a heart attack, then take 200-300 mg of the drug every day for the next month;
• preventive measures to prevent pulmonary embolism - 100 mg Cardio Aspirin daily or 300 mg every other day;
• prevention of thrombosis - 100-200 mg of medication daily.

special instructions

If a patient is planning an operation, he will have to stop using aspirin at least a week in advance, since the medication helps to thin the blood. With extreme caution, this medicine should be taken in the presence of gout, as well as reduced excretion of uric acid, urinary deficiency, history of stomach or duodenal ulcers, bronchial asthma, hypersensitivity to drugs.

During pregnancy

It is allowed to take salicylate only in the 2nd trimester of pregnancy. In the early stages of bearing an infant, taking cardiac aspirin may be accompanied by a risk of intrauterine pathologies of fetal development, and in the last months of pregnancy, when taking salicylic acid, there is a high risk of intracranial hemorrhage in an infant, inhibition of labor activity.

In childhood

For children under 15 years of age, cardiac aspirin may only be prescribed if other NSAIDs have proven ineffective. Drink the drug carefully, monitoring the reaction of the child's body. If the drug causes indomitable vomiting, fever, then this may mean the presence of Rayet's syndrome: you should immediately stop taking the medication, informing your doctor about the occurrence of this side effect.

In case of impaired renal and liver function

Severe renal failure with creatinine clearance less than 30 ml / hour is a contraindication to the use of the drug. If creatinine clearance is more than 30 ml / hour, the drug should be drunk with caution. The diagnosis of class B and C liver dysfunction, a tendency to develop cirrhosis and hepatosis are considered a contraindication for the use of salicylates.

Drug interactions

Before your doctor prescribes cardiac aspirin, tell them about all the drugs you take regularly. Concomitant use with Ibuprofen, magnesium hydroxide, serotonin uptake inhibitors increases the risk of hemorrhagic effusions and bleeding. Joint reception with Methotrexate negatively affects the hematopoietic system, lowering blood sugar. The effect of drugs for gout or arterial hypertension may decrease when taken simultaneously with salicylic acid.

Side effects

The inhibition of the ability of platelets to adhere, the anticoagulant and antiplatelet effects of the drug cause side effects from different body systems, manifested in the following symptoms:

• CNS: dizziness, headache, tinnitus, hearing impairment.
• Circulatory organs: an increase in the number of nose, gastrointestinal bleeding, the appearance of hematomas, cerebral hemorrhages, bleeding gums, hemolytic anemia, hemolysis.
• Gastrointestinal tract: nausea, heartburn, vomiting, pain in the stomach in the stomach or liver, exacerbation of peptic ulcer disease, liver dysfunction.
• Endocrine system: increased sweating, rash, urticaria, itching, allergic rhinitis, bronchospasm, rarely anaphylactic shock or Quincke's edema.

Overdose

Doctors have found that intoxication occurs due to the intake of salicylate at a concentration of more than 100 mg per kg of body weight per day. In this case, the patient develops confusion, dizziness, respiratory failure, convulsions, accompanied by involuntary vomiting. In the presence of such signs, you should immediately call an ambulance, rinse the sick stomach, give activated charcoal or other sorbent. Treatment of severe poisoning is carried out in a hospital setting.

Analogs

Aspirin from the heart has many analogues, the active ingredient of which is acetylsalicylic acid. These include:

• Acylpirine;
• Azsbirin;
• Asprovit;
• Acecardol;
• Acenterin;
• Cardiopyrin;
• Ascopirin;
• Aspikor;
• Anopyrin;
• Thrombotic ACC;
• Thrombopol;
• Trombogard 100;
• Fluspirin.

Price

Cardiac aspirin is manufactured by the German firm Bayer. Depending on the markup for the drug, the price of the pills varies within very different ranges, however, the drug belongs to the available drugs that are sold by pharmacies without a prescription. How much Aspirin Cardio costs can be seen in the table.

thanks

The site provides background information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. A specialist consultation is required!

Aspirin is a widespread non-steroidal anti-inflammatory drug (NSAID) drug that has analgesic, antipyretic, antiplatelet and mild anti-inflammatory effects. Aspirin is used to normalize elevated body temperature, relieve pain syndrome of various localization and origin (for example, headache, toothache, joint pain, menstrual pain, neuralgia, etc.), and also as an anti-inflammatory agent in chronic diseases with a sluggish inflammatory process (for example , rheumatism, arthritis, myocarditis, myositis, etc.). Separately, it is worth canceling the use of Aspirin in low dosages (2-5 times lower than the dosage for relieving pain and lowering temperature) in order to prevent thrombosis and embolism with a high risk of heart attacks, strokes, etc.

Varieties, names and forms of release of Aspirin

Currently, Aspirin, as a rule, means all medicinal products containing as an active ingredient acetylsalicylic acid... However, only a few varieties of the drug produced by the German company Bayer bear the trade name "Aspirin". All other medicines containing acetylsalicylic acid have other official names, but in everyday speech they are all called "Aspirin". That is, there is a transfer of the common, long-known name of the original and patented drug to all of its analogues in terms of the active substance (synonyms and generics). Since the effects, rules of application and dosage of all Aspirin synonyms are exactly the same, in the further text of the article we will describe the properties of the entire set of acetylsalicylic acid preparations, for which the name "Aspirin" is used.

So, Aspirin is available in two dosage forms:
1. Oral tablets;
2. Effervescent tablets for dissolving in water.

Effervescent tablets are produced under three commercial names - "Aspirin 1000", "Aspirin Express" and "Aspirin C", and are used to relieve pain. Aspirin effervescent tablets are currently available in two versions - containing only acetylsalicylic acid or acetylsalicylic acid + vitamin C. Accordingly, the preparation with vitamin C is called "Aspirin C", and without it, simply "Aspirin 1000" and "Aspirin Express".

Oral tablets are available in two varieties - to relieve pain, fever, and for long-term use to prevent thrombosis. Tablets for relieving pain and fever are called ordinary Aspirin, and tablets for preventing thrombosis are called Aspirin Cardio.

Composition

The composition of all forms and varieties of Aspirin as an active substance includes acetylsalicylic acid in the following dosages:

• Effervescent tablets Aspirin 1000 and Aspirin Express - 500 mg of acetylsalicylic acid;
• Effervescent tablets Aspirin C - 400 mg of acetylsalicylic acid and 240 mg of vitamin C;
• Oral tablets Aspirin - 500 mg;
• Aspirin Cardio tablets - 100 mg and 300 mg.

The following components are included in the various types and forms of Aspirin as auxiliary substances:

• Effervescent tablets Aspirin 1000, Aspirin Express and Aspirin C – sodium citrate, sodium carbonate, sodium bicarbonate, citric acid;
• Tablets for oral administration Aspirin - microcrystalline cellulose, corn starch;
• Aspirin Cardio tablets - cellulose, corn starch, methacrylic acid and ethyl acrylate copolymer 1: 1, polysorbate, sodium lauryl sulfate, talc, triethyl citrate.

The composition of all other synonyms and generics, which also implies, when pronouncing the name "Aspirin", is approximately the same as that given above. However, people with allergies or intolerances to any substances should always carefully read the composition of a particular Aspirin, indicated on the package insert attached to the preparation.

Aspirin - recipe

The recipe in Latin in Aspirin is written as follows:
Rp: Tab. "Aspirin" 500 mg
D.t.d. No. 20
S. take orally one tablet 3 times a day.

In the recipe, after the letters "Rp." the form of release of the drug (in this case tablets - Tab.) and its name in quotation marks are indicated. After the name, the dosage is indicated in mg or g. After the letters "D.t.d." indicates the number of tablets that the pharmacist must dispense to a person upon presentation of this prescription. After the letter "S" it is indicated how to take the drug.

Therapeutic action

The action of Aspirin is due to the active substance that is part of the drug - acetylsalicylic acid. This substance can have the following main effects:

• Pain relieving effect;
• Antipyretic action;
• Anti-inflammatory action;
• Antiplatelet action.

The listed effects of acetylsalicylic acid are due to its ability to block the enzyme cyclooxygenase , which provides the production of biologically active substances responsible for the development of a pain impulse, an inflammatory response and an increase in body temperature. By blocking the enzyme, Aspirin stops the synthesis of substances that cause inflammation, fever and pain, thereby eliminating these symptoms. Moreover, the drug eliminates the symptoms, regardless of which organ or part of the body they are localized in. Since Aspirin does not affect the central systems of pain perception, it is classified as a non-narcotic pain reliever.

In low dosages, Aspirin is able to reduce blood clotting and the associated thrombus formation, providing an antiplatelet effect. This effect is achieved by suppressing the production of thromboxane A2, a substance that causes platelets to adhere to each other.

In principle, even in higher dosages, Aspirin also has an antiplatelet effect, but in these cases, in addition to it, the drug also has an analgesic, anti-inflammatory and antipyretic effect, which turns out to be side and unnecessary if only the suppression of thrombus formation is necessary.

Therefore, to achieve an isolated antiplatelet effect, Aspirin must be taken in small dosages, 100 - 300 mg per day. And to reduce the temperature, relieve pain and reduce the inflammatory process, Aspirin is taken in higher dosages, 300-1000 mg per day.

Indications for use

Since the indications for use differ for ordinary Aspirin and Aspirin Cardio, we will consider them separately from each other.

Aspirin effervescent and oral tablets - indications for use

Aspirin tablets for oral administration (in everyday speech they are most often called "ordinary") are indicated for use in the following cases:
1. Symptomatic use for the relief of pain syndrome of various localization and causes:

• Headache;
• Menstrual pain
• Neuralgia;
• Lumbago, etc.

2. In order to reduce body temperature in case of colds and infectious and inflammatory diseases in adults and adolescents over 15 years old.
3. Rheumatic diseases (rheumatism, rheumatic chorea, rheumatoid arthritis, myocarditis, myositis).
4. Collagenosis (progressive systemic sclerosis, scleroderma, systemic lupus erythematosus, etc.).
5. In the practice of allergists and immunologists to reduce the level of sensitization and the formation of persistent tolerance in people suffering from "aspirin asthma" or "aspirin triad".

Aspirin effervescent tablets are indicated for use only for relieving headache or migraine attacks.

It should be remembered that Aspirin effervescent and regular tablets can only stop symptoms, but not cure the disease. Therefore, they can be used to normalize the condition in parallel with medications, the action of which is aimed at curing the disease.

Aspirin Cardio - indications for use

Aspirin Cardio tablets are indicated for use in the following conditions or diseases:

• Primary prevention of myocardial infarction in people with a high risk of its development (for example, with diabetes mellitus, hypertension, high blood cholesterol levels, obesity, smoking, elderly over 65 years of age);
• Prevention of recurrent myocardial infarction;
• Prevention of strokes;
• Prevention of periodic disorders of cerebral circulation;
• Prevention of thromboembolism after surgery on blood vessels (for example, coronary artery bypass grafting, arteriovenous bypass grafting, angioplasty, stenting and endarterectomy of the carotid arteries);
• Prevention of deep vein thrombosis;
• Prevention of thromboembolism of the pulmonary artery and its branches;
• Prevention of thrombosis and thromboembolism during prolonged immobility;
• Unstable and stable angina pectoris;
• Non-atherosclerotic coronary artery disease (Kawasaki disease);
• Aortoarteritis (Takayasu's disease).

Instructions for use

Let's consider the rules for using Aspirin varieties separately to avoid possible confusion.

Aspirin tablets for oral administration - instructions for use

The tablets should not be given to children and adolescents under the age of 15, as they can cause serious, life-threatening complications.

Aspirin tablets must be taken orally after meals with plenty of water (at least 200 ml). The tablet can be swallowed whole, divided into pieces, or chewed. Drinking Aspirin before meals is not recommended as it can provoke discomfort and side effects from the digestive tract.

For pain of moderate and low intensity or increased body temperature, Aspirin is recommended to take 500 - 100 mg (1 - 2 tablets) 2 - 3 times a day. The maximum allowable single dosage is 1000 mg (2 tablets), and the daily dose is 3000 mg (6 tablets). For elderly people over 65 years of age, the maximum allowable daily dosage of Aspirin is 2000 mg (4 tablets). A break of at least 4 hours must be observed between two consecutive doses of tablets.

The duration of the course of using Aspirin for pain relief is a maximum of one week, and for temperature reduction - three days. It is impossible to use Aspirin longer than the indicated periods, since in this case the drug masks the symptoms of the disease and, thereby, does not allow it to be diagnosed in a timely manner and to begin the necessary treatment.

Aspirin effervescent tablets - instructions for use

Before taking, dissolve the tablet in a glass of water and drink the finished solution completely within 10 minutes. For a single dose, 2 tablets of Aspirin are usually dissolved, which corresponds to 1000 mg of acetylsalicylic acid. Effervescent tablets can only be taken again after 4 to 8 hours. During the day without the risk of overdose, adults and adolescents can take no more than 3000 mg of Aspirin (6 tablets), and for elderly people over 65 years of age - no more than 2000 mg (4 tablets).

Effervescent tablets are allowed to be taken regardless of food, since they contain substances that protect the gastric mucosa from the negative effects of acetylsalicylic acid.

If a person has a deficiency of glucose-6-phosphate dehydrogenase, taking Aspirin can provoke hemolytic anemia. Therefore, in the presence of this pathology, care must be taken when taking Aspirin, avoiding its use in large doses, at temperatures or acute infectious diseases.

The use of several painkillers in combination with Aspirin over a long period of time can provoke the development of kidney pathology. In addition, Aspirin is capable of provoking gout attacks, since it reduces the rate of excretion of uric acid from the body.

With prolonged use for headaches, it is possible to develop a "addictive headache" syndrome, when symptoms appear immediately after discontinuation of Aspirin.

With prolonged use of Aspirin, it is necessary to periodically take a general blood test, feces for occult blood and monitor liver function.

Impact on the ability to control mechanisms

All forms and varieties of Aspirin do not affect the ability to control mechanisms, including a car, therefore, while taking the drug, a person can engage in any activity that requires a high concentration of attention and speed of reactions.

Overdose

Aspirin overdose can be acute or chronic. Acute develops with a single dose of Aspirin in a dose of more than 4000 - 5000 mg, and chronic - when taken in an amount of more than 100 mg per 1 kg of body weight per day for two consecutive days, or with prolonged use of relatively large quantities. Acute and chronic overdose of Aspirin is manifested by the same complex of symptoms, which, depending on their severity, determine a moderate or severe degree of intoxication.

For mild to moderate overdose with Aspirin, the following manifestations are characteristic:

• Hearing impairment;
• Increased sweating;
• Headache;
• Confusion of consciousness;
• Rapid breathing.

Treatment of mild to moderate overdose with Aspirin consists in repeated use of sorbents (activated carbon, Polysorb, Polyphepan, etc.), performing gastric lavage and taking diuretics with parallel replenishment of the volume of lost fluid and salts.

A severe overdose of Aspirin is manifested by the following symptoms:

• Very high body temperature;
• Respiratory depression;
• Pulmonary edema;
• Drop in blood pressure;
• Depression of the heart;
• Violation of water and electrolyte balance;
• Disruption of the kidneys up to failure;
• An increase or decrease in blood glucose levels;
• Ketoacidosis;
• Noise in ears;
• Gastrointestinal bleeding;
• Violation of blood clotting from lengthening the bleeding time to the complete absence of blood clot formation;
• Encephalopathy;
• CNS depression (drowsiness, confusion, coma and seizures).

Severe overdose with Aspirin must be treated exclusively in the intensive care unit of the hospital. In this case, the same manipulations are performed as with moderate and mild intoxication, but with the simultaneous maintenance of the work of vital organs and systems.

Interaction with other medicinal products

Aspirin enhances the effect of the following drugs when taken simultaneously:

• Heparin and indirect anticoagulants (for example, Warfarin, Thrombostop, etc.);
• Thrombolytics (drugs that dissolve blood clots), anticoagulants (drugs to reduce blood clotting), and antiplatelet agents (drugs that prevent blood clots by preventing platelets from sticking together);
• Selective serotonin reuptake inhibitors (eg, Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram, etc.);
• Digoxin;
• Drugs for lowering blood glucose levels (hypoglycemic agents) for oral administration;
• Valproic acid;
• Drugs from the NSAID group (Ibuprofen, Nimesulide, Diclofenac, Ketonal, Indomethacin, etc.);
• Ethanol.

Given the enhanced effects of these drugs, when taken simultaneously with Aspirin, it is necessary to reduce their therapeutic dosage.

It should be remembered that when taking Aspirin with anticoagulants, thrombolytics, antiplatelet agents, selective serotonin reuptake inhibitors and alcoholic beverages, the risk of bleeding and ulceration of the gastric mucosa increases. Taking Aspirin with other drugs of the NSAID group increases the risk of side effects and bleeding from the gastrointestinal tract.

In addition, Aspirin can reduce the therapeutic effect of the following drugs:

• ACE inhibitors (Berlipril, Captopril, Lisinopril, Perindopril, etc.);
• Drugs with the ability to remove uric acid from the body (Probenecid, Benzbromaron, etc.).

The effects of Aspirin are weakened when taken simultaneously with drugs containing ibuprofen, as well as glucocorticosteroid hormones.

Aspirin for the prevention of cardiovascular and oncological diseases - video

Aspirin for children

Children with influenza, acute respiratory viral infections and chickenpox are not recommended to give Aspirin, since the drug can provoke the development of Reye's syndrome, which is a very severe damage to the central nervous system with liver failure. Death occurs in half of children with Reye's syndrome. The risk of developing this syndrome while using Aspirin exists only in children under 15 years old, therefore, it is not recommended to give all drugs containing acetylsalicylic acid to them before this age.

In the developed countries of Europe and the United States, Aspirin has been banned for children under 15 years old since the 1980s, and in Russia there is no such ban. Therefore, the undesirability of using Aspirin in children under 15 years old is reduced solely to recommendations.

In order to reduce body temperature, relieve pain and reduce the severity of the inflammatory process for children under 15 years of age, it is recommended to use drugs containing ibuprofen or paracetamol, since they are safer.

Application during pregnancy

Aspirin can have a negative effect on the course of pregnancy and fetal development, therefore its use is strictly prohibited in the first and third trimesters (from 1 to 13 and from 28 to 40 weeks of gestation). In the first trimester, the drug can provoke heart defects and cleavage of the upper palate in the fetus, and in the third trimester - inhibition of labor, prolonged pregnancy and intracranial hemorrhage in a child.

During the second trimester of pregnancy, Aspirin can be used only when urgently needed, when it is not possible to replace it with another drug, and the benefits to the mother clearly outweigh the risks to the fetus. The maximum allowable dosage of Aspirin in the second trimester of pregnancy is 150 mg per day.

Aspirin passes into milk in a small amount, which does not cause any adverse reactions in the child. Therefore, when taking Aspirin in small dosages for a short period of time, you do not need to stop breastfeeding and transfer the baby to formula. However, if Aspirin is taken in high dosages or for a long period of time, then breastfeeding should be discontinued.

Aspirin for acne face (mask with Aspirin)

Aspirin, in the form of an external agent applied to the skin of the face, has been used very successfully by dermatologists to treat inflammation, including acne, acne, etc. Currently, specially for the cosmetic industry and the practice of dermatologists, aspirin is produced in the form of powders, pastes and solutions, which are used in the complex therapy of inflammatory processes of the skin. Face masks with Aspirin have the following effects:

• Cleans the skin and removes blackheads;
• Reduces the production of sebum by the skin glands;
• Shrinks pores;
• Reduces skin inflammation;
• Prevents the formation of acne and acne;
• Eliminates edema;
• Eliminates acne marks;
• Exfoliates dead cells of the epidermis;
• Keeps the skin firm.

At home, the simplest and most effective method of using Aspirin to improve the structure of the skin and eliminate acne are masks with this drug. For their preparation, you can use ordinary uncoated tablets purchased at the pharmacy. The face mask with Aspirin is a mild version of chemical peeling, therefore it is recommended to do it no more than 2 - 3 times a week, and during the day after applying the cosmetic procedure, do not be in direct sunlight.

Consider various options for masks with Aspirin for different skin types:
1. For oily and very oily skin. The mask unclogs pores, soothes the skin and reduces inflammation. Grind 4 Aspirin tablets into powder and mix it with a tablespoon of water, add a teaspoon of honey and vegetable oil (olive, sunflower, etc.). Apply the resulting mixture on the face and rub in with massaging movements for 10 minutes, then rinse with warm water.
2. For normal to dry skin. The mask reduces inflammation and soothes the skin. Grind 3 Aspirin tablets and mix with a tablespoon of yogurt. Apply the ready-made mixture to the face, leave for 20 minutes and rinse with warm water.
3. For problem skin with a lot of inflammation. The mask effectively reduces inflammation and prevents the appearance of new acne. To prepare the mask, several Aspirin tablets are crushed and poured with water until a thick gruel is formed, which is applied pointwise to acne or pimples and left for 20 minutes, then washed off.

Side effects

All varieties of Aspirin can provoke the following side effects from various organs and systems:
1. Digestive system:

• Nausea;
• Vomiting;
• Gastrointestinal bleeding (black stools, vomiting with blood, occult blood in the stool);
• Anemia due to bleeding;
• Erosive and ulcerative lesions of the digestive tract;
• Increased activity of liver enzymes (AST, ALT, etc.).

2. Central nervous system:

• Dizziness;
• Noise in ears;
• Hearing impairment;
• Headache.

3. Blood system:

• Increased bleeding;
• Bleeding of various localization (nasal, gingival, uterine, etc.);
• Hemorrhagic purpura;
• Education;
• Thrombocytopenia (decreased level of platelets in the blood);
• Taking methotrexate at a dosage of more than 15 mg per week;
• Severe renal or hepatic impairment;
• Heart failure in the stage of decompensation;
• I and III trimesters of pregnancy;
• Breastfeeding period;
• Age under 15;
• Hypersensitivity to the components of Aspirin.

Aspirin's analogs

All varieties of Aspirin on the pharmaceutical market have analogue preparations that also contain acetylsalicylic acid as an active substance. In principle, preparations containing the same active substance are correctly called synonyms, but the term "analogs" can also be used, indicating what exactly is meant by it.

So, analogues (in the understanding of synonyms) Aspirin in the form of effervescent tablets and tablets for oral administration are the following medicines:

• Aspivatrin effervescent tablets;
• Aspinat tablets and effervescent tablets;
• Aspitrin tablets;
• Asprovit effervescent tablets;
• Acetylsalicylic acid tablets;
• Atsbirin effervescent tablets;
• Nextrim Fast tablets;
• Taspir effervescent tablets;
• Upsarin Oopsa effervescent tablets;
• Fluspirin effervescent tablets.

Aspirin C synonyms

• Aspivit effervescent tablets;
• Aspinat C effervescent tablets;
• Asprovit C effervescent tablets;
• Upsarin Oopsa with vitamin C effervescent tablets.

Synonymous with Aspirin Cardio are the following drugs:

• ASK cardio;
• Aspikor;
• Aspinat Cardio;
• Acecardol;
• Acetylsalicylic acid Cardio;
• Cardiask;
• Cardiopyrin;
• Thrombo Ass;
• Trombogard;
• Thrombopol.

Aspirin - reviews

Most of the reviews left by people relate to either the use of Aspirin to improve the condition of the skin of the face, or the intake of Aspirin Cardio in order to thin the blood and prevent heart attacks and strokes.

Almost all reviews on the use of Aspirin in face masks are positive (more than 95%), due to the excellent cosmetic effects of the drug. Women who have used Aspirin in this way note that masks dry out the skin, eliminate inflammation, completely remove small acne, reduce large blackheads, remove blackheads and tighten pores. After a course of several masks, the skin becomes much better, cleaner and more beautiful, which, of course, is liked by women who leave positive feedback on the use of Aspirin.

More than 95% of reviews about Aspirin Cardio are also positive, which is due to a significant improvement in well-being while taking the drug, as well as the normalization of the heart, which is felt not only subjectively, but is also confirmed by the data of analyzes and examinations. In the reviews, many people note that Aspirin Cardio is safe for the stomach and is well tolerated, which are also the advantages of the drug.

Paracetamol or Aspirin?

When choosing between Paracetamol and Aspirin, it is necessary to clearly understand for what purpose the drug will be used and how old the person is. If we are talking about a child under 15 years old, then Paracetamol should always be chosen, since Aspirin can cause Reye's syndrome, manifested by liver failure and encephalopathy, and ending in half of the cases fatal.

If we are talking about an adult, then to reduce the temperature, it is recommended to first use Paracetamol, and if it turns out to be ineffective, then take Aspirin. It is not recommended to take Aspirin for fever as a first line treatment, since Paracetamol is safer and in many cases is equally effective.

For blood thinning and as part of the complex therapy of cardiovascular diseases and thrombosis, it is necessary to use only Aspirin. It is advisable to choose a specialized drug Aspirin Cardio, but if it is impossible to acquire it, you can take regular Aspirin in half or a quarter of a tablet.

Which antipyretic is best for a child: aspirin or paracetamol - video

Joint reception of Aspirin and Analgin for colds and flu

The popular way to lower the temperature in viral infections and colds, which consists in taking Aspirin and Analgin at the same time, cannot be used, since this combination of drugs is very dangerous.

So, Analgin can cause anaphylactic shock or the almost complete disappearance of blood leukocytes, that is, conditions that often end in death. No less severe, but not so deadly complications of taking Analgin are persistent hypothermia (low body temperature) and collapse. Due to the rather high incidence of such side effects, Analgin has been banned for use as an antipyretic agent since the 60s in Europe and from the 70s in the USA. The routine use of Analgin at temperatures has not been recommended by WHO since 1991.

Aspirin is able to enhance the negative effects of Analgin, which makes this combination of drugs very dangerous. Therefore, at elevated body temperature, you should not take Aspirin and Analgin at the same time.

Cardiomagnet and Aspirin Cardio - what's the difference?

The difference between Aspirin Cardio and Cardiomagnil is that the former contains only acetylsalicylic acid as an active substance, and the latter also contains magnesium hydroxide in addition to it. Magnesium hydroxide in the composition of Cardiomagnyl protects the gastric mucosa from the negative effects of acetylsalicylic acid. That is, the therapeutic effects of both drugs are the same, but Cardiomagnet is safer from the point of view of ulceration of the gastrointestinal mucosa.

Aspirin and Aspirin Cardio - price

Currently, the cost of Aspirin varieties fluctuates in pharmacy chains within the following limits:

• Aspirin C effervescent tablets 10 pieces - 165 - 241 rubles;
• Aspirin Express 500 mg 12 pieces - 178 - 221 rubles;
• Aspirin tablets for oral administration, 500 mg 20 pieces - 174 - 229 rubles;
• Aspirin Cardio 100 mg 28 tablets - 127 - 147 rubles;
• Aspirin Cardio 100 mg 56 tablets - 225 - 242 rubles;
• Aspirin Cardio 300 mg 20 tablets - 82 - 90 rubles.

Before use, you must consult a specialist.