INN: Acetylsalicylic acid
Manufacturer: Bayer Pharma AG
Anatomical-therapeutic-chemical classification: Acetylsalicylic acid
Registration number in the RK: No. RK-LS-5 No. 013404
Registration period: 13.03.2019 - 13.03.2029
KNF (drugs are included in the Kazakhstan National Formulary of Medicines)
ALO (Included in the List of Free Outpatient Drug Provision)
UNIT (Included in the List of Medicines under the guaranteed volume of medical care to be purchased from a Single Distributor)
Maximum purchase price in the Republic of Kazakhstan: 7.35 KZT
Instructions
Tradename
Aspirin cardio
International non-proprietary name
Acetylsalicylic acid
Dosage form
Enteric-coated tablets 100 mg and 300 mg
Composition
One tablet contains
active substance - acetylsalicylic acid 100 mg or 300 mg,
excipients: cellulose powder, corn starch, eudragit L30D, polysorbate 80, sodium lauryl sulfate, talc, triethyl citrate.
Description
Round, biconvex, slightly rough, beveled to the edge of a white tablet, at the break - a homogeneous mass of white, surrounded by a shell of the same color
Pharmacotherapeutic group
Anticoagulants. Platelet aggregation inhibitors excl. heparin. Acetylsalicylic acid
ATX code B01AC06
Pharmacological properties
Pharmacokinetics
After oral administration, acetylsalicylic acid (ASA) is rapidly and completely absorbed from the gastrointestinal tract.
During and immediately after absorption, acetylsalicylic acid is converted into the main active metabolite, salicylic acid.
The maximum concentration of acetylsalicylic acid in the blood plasma is reached after 10-20 minutes, the maximum concentration of salicylic acid - after 0.3-2 hours.
Due to the fact that the enteric coating of Aspirin Cardio® tablets is resistant to the action of acid, the release of the active substance does not occur in the stomach, but in the alkaline medium of the intestine. Due to this, the absorption of acetylsalicylic acid is delayed by 3-6 hours in comparison with non-enteric coated tablets.
Acetylsalicylic and salicylic acids bind to a significant extent with plasma proteins and are rapidly distributed in tissues.
Salicylic acid is excreted in breast milk and crosses the placental barrier.
Salicylic acid is metabolized mainly in the liver with the formation of metabolites - salicylurate, salicylophenolic glucuronide, salicylic glucuronide, gentisic and gentizuric acids.
The elimination of salicylic acid is dose-dependent.
The half-life when taking the drug in low doses is 2-3 hours, when taking the drug in high doses - 15 hours. Salicylic acid and its metabolites are excreted mainly by the kidneys.
Pharmacodynamics
The mechanism of action of acetylsalicylic acid is based on irreversible inhibition of cyclooxygenase (COX-1), as a result of which the synthesis of thromboxane A2 is blocked and platelet aggregation is suppressed. The antiplatelet effect is most pronounced in platelets, since they are not able to re-synthesize cyclooxygenase.
It is believed that acetylsalicylic acid has other mechanisms for suppressing platelet aggregation, which expands the scope of its application in various vascular diseases.
Acetylsalicylic acid belongs to the group of non-steroidal anti-inflammatory drugs, and has analgesic, antipyretic and anti-inflammatory effects.
Higher doses are used to relieve pain and minor febrile conditions such as colds and flu, to reduce fever, reduce muscle and joint pain, and for acute and chronic inflammatory diseases such as rheumatoid arthritis, osteoarthritis and ankylosing spondylitis.
Indications for use
To reduce the risk of death in patients with suspected acute myocardial infarction
To reduce the risk of morbidity and mortality in patients with myocardial infarction
For secondary prevention of stroke
To reduce the risk of developing transient ischemic attack (TIA) and stroke in patients with TIA
To reduce morbidity and mortality in stable and unstable angina
For the prevention of thromboembolism after surgery and invasive interventions on the vessels (for example, percutaneous transluminal catheter angioplasty, coronary artery bypass grafting, carotid endarterectomy, arteriovenous bypass grafting)
For the prevention of deep vein thrombosis and pulmonary embolism during prolonged immobilization (for example, after major surgery)
To reduce the risk of developing acute myocardial infarction in the presence of cardiovascular risk factors (eg, diabetes mellitus, hyperlipidemia, hypertension, obesity, smoking, old age)
Method of administration and dosage
For oral administration.
Aspirin cardio enteric coated tablets should be taken before meals with plenty of liquid.
To reduce the risk of death in patients with acute myocardial infarction
The initial dose of 100-300 mg (the first tablet must be chewed for faster absorption) should be taken by the patient as soon as possible after the development of acute myocardial infarction is suspected.
In the next 30 days after the development of myocardial infarction, a dose of 100-300 mg / day should be maintained.
After 30 days, the need for further therapy should be considered to prevent the development of recurrent myocardial infarction.
To reduce the risk of morbidity and mortality in patients with myocardial infarction
100-300 mg / day
For secondary prevention of stroke
100-300 mg / day
To reduce the risk of TIA and stroke in patients with TIA
100-300 mg / day
To reduce morbidity and mortality in stable and unstable angina
100-300 mg / day
For the prevention of thromboembolism after surgery and invasive interventions on the vessels
100-300 mg / day
For the prevention of deep vein thrombosis and pulmonary embolism
100-200 mg / day or 300 mg every other day
To reduce the risk of developing acute myocardial infarction
100 mg daily or 300 mg every other day.
Side effects
The side effects listed below are based on spontaneous post-marketing reports and experience with all forms of Aspirin, including oral forms for short and long courses of treatment.
Therefore, their frequency representation in accordance with the CIOMS III categories is not possible.
Often:
Dyspepsia, abdominal pain and pain in the gastrointestinal area
Seldom:
Inflammation of the gastrointestinal tract, ulcers of the mucous membrane of the stomach and duodenum (extremely rarely, potentially leading to gastrointestinal bleeding and perforations with corresponding clinical and laboratory symptoms)
Rarely - very rarely:
Severe cases of bleeding, such as gastrointestinal bleeding, cerebral hemorrhage (especially in patients with uncontrolled arterial hypertension and / or receiving concomitant anticoagulant therapy), which in some cases can be life-threatening.
Rarely:
Severe hypersensitivity reactions including anaphylactic shock
Transient liver dysfunctions with increased activity of "hepatic" transaminases
With an unknown frequency:
Bleeding such as perioperative bleeding, hematoma, epistaxis (epistaxis), bleeding from the genitourinary tract, bleeding gums
Hemolysis and hemolytic anemia in patients with severe glucose-6-phosphate dehydrogenase deficiency
Renal dysfunction and acute renal failure
Hypersensitivity reactions with corresponding clinical and laboratory manifestations (asthmatic syndrome, mild to moderate reactions from the skin, respiratory tract, gastrointestinal tract and cardiovascular system, including skin rash, urticaria, edema, pruritus, rhinitis, mucosal edema nasal membranes, cardio-respiratory distress syndrome)
Dizziness and ringing in the ears, which can also be a sign of drug overdose.
Contraindications
- hypersensitivity to acetylsalicylic acid or other salicylates, or to any of the excipients of the drug
History of bronchial asthma induced by the intake of salicylates and substances of similar action, in particular non-steroidal anti-inflammatory drugs (NSAIDs)
Acute period of peptic ulcer
Hemorrhagic diathesis
Severe renal failure
Severe liver failure
Severe heart failure
Combined use with methotrexate at a dose of 15 mg per week or more
Last Trimester of Pregnancy for Aspirin Cardio 100 mg (see section "Pregnancy and lactation")
Pregnancy period (all 3 trimesters) for Aspirin Cardio 300 mg (see section "Pregnancy and lactation")
Drug interactions
Contraindicated interactions
Methotrexate at a dose of 15 mg / week or more
With the simultaneous use of ASA with methotrexate, the hematological toxicity of methotrexate increases due to the fact that NSAIDs reduce the renal clearance of methotrexate, and salicylates, in particular, displace it from its connection with plasma proteins.
Combinations requiring caution
Ibuprofen
Ibuprofen, when used simultaneously with ASA, antagonizes its positive effect on platelets.
In patients with an increased risk of cardiovascular diseases, the simultaneous use of ibuprofen and ASA leads to a decrease in its cardioprotective effect.
Anticoagulants, thrombolytic and other antiplatelet drugs
There is a risk of bleeding.
Other NSAIDs with salicylates in a high dose (3 g / day or more)
Due to the synergism of the action, the risk of ulceration of the gastrointestinal mucosa and bleeding increases.
Selective serotonin reuptake inhibitors
Due to the synergistic action, the risk of bleeding from the upper gastrointestinal tract increases.
Digoxin
By reducing renal clearance, ASA increases the concentration of digoxin in the blood plasma.
Antidiabetic agents such as insulin, sulfonylurea derivatives
High doses of ASA enhance the effect of hypoglycemic drugs due to the hypoglycemic effect of acetylsalicylic acid and the displacement of sulfonylurea derivatives from the connection with blood plasma proteins.
Diuretics in combination with high doses of ASA
There is a decrease in glomerular filtration as a result of a decrease in the synthesis of prostaglandins in the kidneys.
Systemic glucocorticosteroids (GCS), with the exception of hydrocortisone used for replacement therapy of Addison's disease
With corticosteroid therapy, the level of concentration of salicylates in the blood decreases and there is a risk of developing an overdose of salicylates after stopping treatment, since corticosteroids increase the excretion of the latter.
Angiotensin-converting enzyme (ACE) inhibitors in combination with high doses of ASA
There is a decrease in glomerular filtration as a result of inhibition of prostaglandins, which have a vasodilating effect, respectively, a weakening of the hypotensive effect.
Valproic acid
The toxicity of valproic acid increases due to displacement from the connection with blood plasma proteins.
Ethanol
There is an increased risk of damage to the gastrointestinal mucosa and lengthening of bleeding time as a result of the mutual enhancement of the effects of ASA and ethanol.
Uricosuric drugs such as benzbromarone, probenecid
The uricosuric effect is reduced due to the competitive renal tubular elimination of uric acid.
special instructions
The drug should be used with caution in the following conditions:
For hypersensitivity to analgesics, anti-inflammatory, antirheumatic drugs and other types of allergies
A history of gastrointestinal ulceration, including chronic or recurrent peptic ulcer disease or gastrointestinal bleeding
When used together with anticoagulants (See section "Drug Interactions")
In patients with impaired renal or circulatory function (eg, vascular renal disease, congestive heart failure, reduced blood volume, major surgery, sepsis, or severe bleeding), as acetylsalicylic acid may further increase the risk of kidney damage or acute renal insufficiency
In patients with severe glucose-6-phosphate dehydrogenase (G6PD) deficiency, acetylsalicylic acid can induce the development of hemolysis or hemolytic anemia. Factors that can increase the risk of hemolysis include, for example, high doses of the drug, fever, or acute infections
If liver function is impaired
Ibuprofen may interfere with the inhibitory effect of ASA on platelet aggregation. Patients receiving ASA treatment and taking ibuprofen for pain relief should inform their physician.
ASA can provoke bronchospasm, as well as cause attacks of bronchial asthma and other hypersensitivity reactions. Risk factors include a history of bronchial asthma, hay fever, nasal polyposis, chronic respiratory diseases, and allergic reactions to other substances (eg, skin reactions, itching, urticaria).
Due to the inhibitory effect on platelets, the use of Aspirin cardio may be associated with an increased risk of bleeding. Due to this ability to suppress platelet aggregation, which persists for several days after taking the drug, acetylsalicylic acid can lead to increased bleeding during and after surgical interventions (including minor surgical interventions, for example, tooth extraction).
Bleeding can lead to the development of acute or chronic posthemorrhagic / iron deficiency anemia (for example, due to latent microbleeding) with corresponding clinical and laboratory signs and symptoms such as asthenia, pallor of the skin, hypoperfusion.
ASA in low doses reduces the excretion of uric acid, which can provoke the development of gout in susceptible individuals.
Application in pediatrics
There is a relationship between taking Aspirin and the development of Reye's syndrome when used in children with certain viral diseases. The risk may be increased with the combined use of drugs containing ASA, however, a causal relationship has not been identified. The development of persistent vomiting in these conditions may be a sign of Reye's syndrome.
Reye's syndrome is a very rare disease that can cause brain and liver damage and can be fatal.
In this regard, Aspirin cardio should not be used in children and adolescents under 18 years of age, except in cases of special indications.
Application during pregnancy
Inhibition of prostaglandin synthesis can have negative effects on pregnancy and embryo or fetal development. Epidemiological data indicate an increased risk of malformations and malformations with the use of inhibitors of prostaglandin synthesis in early pregnancy. In this case, it is believed that the risk increases with increasing dose and duration of treatment. The available data do not confirm any relationship between the use of acetylsalicylic acid and an increased risk of premature termination of pregnancy. The available epidemiological data regarding the development of malformations are contradictory, however, an increased risk of developing a defect - non-closure of the anterior abdominal wall cannot be excluded. Prospective use of ASA in the early period of pregnancy (1-4 months) in 14,800 women / children did not reveal any association with an increased incidence of malformations.
Preclinical data have shown reproductive toxicity. The appointment of drugs containing acetylsalicylic acid in the first and second trimesters of pregnancy is not indicated, until it is dictated by extreme necessity.
With this in mind, in the first and second trimesters of pregnancy Aspirin cardio in a dose of 100 mg can be used only after a doctor has carefully evaluated the risk / benefit ratio.
When using drugs containing acetylsalicylic acid by a woman during conception, or in the first and second trimester of pregnancy, it is necessary to use the lowest possible dose of the drug and conduct a short course of treatment.
In the third trimester of pregnancy, all inhibitors of prostaglandin synthesis can cause the fetus:
cardiopulmonary toxicity (with premature closure of the botalloid duct and pulmonary hypertension)
renal dysfunction, which can progress to renal failure with oligohydramnios;
In the mother and fetus at the end of pregnancy:
a possible increase in bleeding time, an antiplatelet effect that can occur even with small doses
suppression of the contractile activity of the uterus, which can lead to prolonged birth or prolonged labor
In this regard, ASA is contraindicated for use in the third trimester of pregnancy.
Application during lactation
Salicylates and their metabolites are excreted in breast milk in small amounts. Accidental intake of salicylates during lactation does not require termination of breastfeeding. However, if a doctor prescribes long-term use of the drug or taking acetylsalicylic acid in high doses, breastfeeding should be discontinued.
Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
Considering possible side effects such as dizziness, care must be taken when driving or driving potentially dangerous machinery.
Overdose
Salicylate intoxication (develops when ASA is taken at a dose of more than 100 mg / kg / day for more than 2 days) may result from prolonged use of toxic doses of the drug as a result of improper therapeutic use of the drug (chronic intoxication) or a single accidental or deliberate intake of a toxic dose of the drug an adult or a child (acute intoxication).
Chronic overdose symptoms are nonspecific and often difficult to diagnose.
Chronic overdose of mild severity usually develops only after repeated use of large doses of the drug.
Symptoms:dizziness, tinnitus, hearing loss, increased sweating, nausea and vomiting, headache and confusion. These symptoms disappear after reducing the dose of the drug. Tinnitus can appear when the concentration of ASA in blood plasma is from 150 to 300 μg / ml. More severe symptoms appear when the ASA concentration is more than 300 μg / ml.
Acute intoxication
Symptoms: othe main manifestation of acute intoxication is a severe violation of the acid-base state, the manifestations of which can vary depending on the age of the patient and the severity of intoxication. In children, the development of metabolic acidosis is most typical. The severity of intoxication cannot be assessed only by the concentration of ASA in the blood plasma. Absorption of ASA can be delayed due to delayed gastric emptying, the formation of calculi in the stomach, or as a result of taking enteric-coated tablets.
Treatment:is carried out in accordance with accepted standards and depends on the severity of intoxication and the clinical picture and should be aimed mainly at accelerating the elimination of the drug and restoring the water-electrolyte balance and acid-base state.
Mild to moderate overdose
Symptoms:tachypnea, hyperventilation, respiratory alkalosis (alkalemia and alkaluria), increased sweating, nausea and vomiting.
Treatment: gastric lavage, repeated intake of activated carbon, forced diuresis with drugs for urine alkalization, restoration of water-electrolyte balance and acid-base state.
Moderate to severe overdose
Symptoms:
Respiratory alkalosis with compensatory metabolic acidosis (acidemia and aciduria)
Hyperpyrexia
Respiratory disorders: hyperventilation, noncardiogenic pulmonary edema, respiratory depression, asphyxia
Violations of the cardiovascular system: heart rhythm disturbances, arterial hypotension, inhibition of cardiac activity (changes in blood pressure, electrocardiogram)
Water and electrolyte imbalance: dehydration, impaired renal function from oliguria up to the development of renal failure (hypokalemia, hypernatremia, hyponatremia)
Impaired glucose metabolism: hyperglycemia, hypoglycemia (especially in children), ketoacidosis
Tinnitus, deafness
Gastrointestinal bleeding
Hematological disorders: from inhibition of platelet aggregation to coagulopathy, prolongation of prothrombin time, hypoprothrombinemia
Neurological disorders: toxic encephalopathy and depression of the central nervous system (drowsiness, confusion, coma, convulsions)
Treatment: immediate hospitalization in specialized departments for emergency therapy - gastric lavage, repeated intake of activated carbon, forced alkaline diuresis, hemodialysis.
Restoration of water-electrolyte balance and acid-base state, symptomatic therapy.
Release form and packaging
On 14 or 10 tablets in a blister strip of polypropylene film and aluminum foil.
2 blister packs containing 14 tablets or 3 blister packs containing 10 tablets are placed in a cardboard box along with instructions for use.
Storage period
5 years Do not use after the expiration date.
Storage conditions
Store at a temperature not exceeding 25С.
Keep out of the reach of children!
Vacation conditions Without prescription
Manufacturer
Bayer Pharma AG, Leverkusen, Germany
Marketing Authorization Holder
Bayer Pharma AG, Berlin, Germany
Packer
Bayer Bitterfeld GmbH, Germany
The address of the organization hosting on the territory of the Republic of Kazakhstan
claims from consumers for the quality of the product (goods)
Bayer KAZ LLP, st. Timiryazeva, 42,
business center "Expo-City", pav. fifteen
050057 Almaty, Republic of Kazakhstan,
tel. +7 727 258 80 40,
fax: +7 727 258 80 39, e-mail: [email protected]
Attached files
| 991929101477976757_en.doc | 106 kb |
| 145875501477977923_kz.doc | 111.5 kb |
Composition
1 tablet of ASPIRIN® CARDIO contains acetylsalicylic acid 100 mg as an active substance.
excipients: cellulose, powder, corn starch; shell: methacrylic acid and ethyl acrylate copolymer (1: 1), polysorbate 80, sodium lauryl sulfate, talc, triethyl citrate.
Description
White coated round biconvex tablets.
Pharmacotherapeutic group
Platelet aggregation inhibitors, excluding heparin.
ATC code: B01AC06.
pharmachologic effect
Pharmacodynamics
The mechanism of the antiplatelet action of acetylsalicylic acid (ASA) is based on irreversible inhibition of cyclooxygenase (COX-1), as a result of which the synthesis of thromboxane Ar is blocked and platelet aggregation is suppressed. This effect is long-term and usually lasts for the entire eight-day period of the platelet's life.
Acetylsalicylic acid inhibits the formation of prostacyclin (prostaglandin, which has the property of stimulating platelet aggregation and vasoconstrictor action) in the endothelial cells of the vascular walls. This effect is temporary.
As the concentration of acetylsalicylic acid in the blood decreases, the production of prostacyclin resumes in the nucleated endothelial cells.
As a consequence, a single use of a low dose (< 300 мг/ сутки) ацетилсалициловой кислоты вызывает ингибирование тромбоксана Аг в тромбоцитах без заметного ухудшения образования простациклина.
ASA also has anti-inflammatory, analgesic and antipyretic effects.
Pharmacokinetics
After oral administration, ASA is rapidly and completely absorbed from the gastrointestinal tract (GIT). ASA is partially metabolized during absorption. During and after absorption, ASA is converted into the main metabolite - salicylic acid, which is metabolized mainly in the liver under the influence of enzymes with the formation of such metabolites as phenyl salicylate, glucuronide salicylate and salicyluric acid, found in many tissues and in urine.
Depending on the composition, absorption of acetylsalicylic acid after oral administration is rapid and complete. The residual acetyl part of acetylsalicylic acid undergoes partial hydrolytic degradation during its passage through the mucous membranes of the gastrointestinal tract. In women, the metabolic process is slower (less enzyme activity in the blood serum). The maximum concentration of ASA in blood plasma is achieved within 10-20 minutes after ingestion, salicylic acid - after 0.3-2 hours. Due to the fact that the tablets are coated with an acid-resistant membrane, ASA is released not in the stomach (the membrane effectively blocks the dissolution of the drug in the stomach), but in the alkaline medium of the duodenum. Thus, the absorption of ASA in the form of enteric-coated tablets is delayed by 3-6 hours compared to conventional (without such a coating) tablets.
The excretion of salicylic acid is dose-dependent, since its metabolism is limited by the capabilities of the enzymatic system. The half-life is from 2-3 hours when using ASA in low doses and up to 30 hours when using the drug in high doses. Unlike other salicylates, with repeated administration of the drug, non-hydrolyzed ASA does not accumulate in the blood serum. Salicylic acid and its metabolites are excreted by the kidneys.
The half-life of acetylsalicylic acid is only a few minutes; the half-life of salicylic acid is 2 hours after taking a dose of 0.5 g of acetylsalicylic acid and 4 hours after administration of 1 g; after taking a single dose of 5 g, the half-life is extended to 20 hours.
ASA and salicylic acid strongly bind to blood plasma proteins (from 49 to 70% - ASA, from 66% to 98% - salicylic acid) and are quickly distributed in the body. Salicylic acid crosses the placenta and is excreted in breast milk.
Salicylic acid has been found in cerebrospinal fluid and synovial fluid after taking acetylsalicylic acid.
Indications for use
Unstable angina as part of standard therapy.
Acute myocardial infarction as part of standard therapy.
Prevention of recurrent myocardial infarction.
Prevention of repeated transient ischemic attack (TIA) and repeated cerebral infarction.
Prevention of thrombosis after surgery and invasive interventions on the vessels (for example, after coronary artery bypass grafting (CABG) or primary percutaneous coronary intervention (PPCI)).
Note: Acetylsalicylic acid in a single dose of 100 mg is not intended for the treatment of pain syndrome due to an inappropriate amount of active ingredient.
Method of administration and dosage
It is advisable to take tablets of the drug ASPIRIN® CARDIO at least 30 minutes before a meal with plenty of water.
The tablets should not be crushed, divided or chewed to ensure the release of the active substance in the alkaline environment of the intestine.
For the treatment of acute myocardial infarction, the first tablet should be bitten or chewed.
ASPIRIN® CARDIO tablets are taken once a day. ASPIRIN® CARDIO is intended for long-term use. The duration of therapy is determined by the doctor.
Unstable angina pectoris: 100 mg once a day.
Acute myocardial infarction: 100 mg once a day.
Prevention of recurrent myocardial infarction: 300 mg once a day.
Prevention of repeated transient ischemic attack (TIA) and repeated cerebral infarction: 100 mg once a day.
Prevention of thrombosis after surgery and invasive interventions on the vessels (for example, after coronary artery bypass grafting (CABG) or primary percutaneous coronary intervention (PPCI)): 100 mg once a day. It is recommended to start antiplatelet therapy with acetylsalicylic acid 24 hours after CABG or PPCI.
Actions when you miss one or more doses of the drug
Take the missed pill as soon as you remember about it and then continue taking it as usual. To avoid doubling the dose, do not take the missed pill if the next pill is approaching.
Features of the action of the drug at the first admission and at its cancellation
No peculiarities of the action of the drug at the first administration and its cancellation were observed.
Side effect
To estimate the incidence of side effects, the following incidence rate is applied:
Often
: ≥1/10
Often
: from ≥1 / 100 to< 1/10
Infrequently
: ≥1 / 1,000 to< 1/100
Seldom
: ≥1 / 10,000 to< 1/1 000
Rarely:<10000
Unknown
: frequency cannot be determined based on available data
Disturbances from the circulatory and lymphatic system
Rare and very rare cases of severe bleeding, such as cerebral bleeding, have been reported, especially in patients with uncontrolled hypertension and / or with concomitant anticoagulant therapy, potentially life-threatening in some cases.
Cases of hemolysis and hemolytic anemia have been reported in patients with severe glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Bleeding such as nosebleeds, bleeding gums, bleeding from the skin, or urogenital bleeding, possibly with an increase in the duration of the bleeding. This action can persist for 4 to 8 days after application.
Gastrointestinal disorders
Frequent:
Gastrointestinal disorders such as heartburn, nausea, vomiting, abdominal pain, and diarrhea.
Minor blood loss from the gastrointestinal tract (micro-bleeding).
Infrequent:
An ulcer of the gastrointestinal tract, which in very rare cases can lead to perforation.
Chronic gastrointestinal bleeding.
Long-term use of the drug Aspirin® Cardio 100 mg can cause iron deficiency anemia due to latent loss of blood from the gastrointestinal tract.
Acute gastrointestinal bleeding.
If the patient has black feces (tarry stools) or bloody vomiting, both symptoms are signs of severe bleeding in the stomach, it is necessary to urgently inform the attending physician.
Nervous system disorders
Headache, dizziness, hearing impairment, tinnitus, or confusion may be signs of an overdose (see Overdose section).
Skin and subcutaneous tissue disorders
Infrequent:
Skin reactions (very rarely up to erythema multiforme exudative).
Immune system disorders
Rare:
Hypersensitivity reactions from the skin, respiratory tract and cardiovascular system, especially in patients with asthma. These symptoms include hypotension, attacks of shortness of breath, rhinitis, nasal congestion, anaphylactic shock, and angioedema.
Hepatobiliary system disorders
Very rare:
Elevated levels of "liver" blood enzymes.
Kidney and urinary tract disorders
Very rare:
Renal failure and acute renal failure.
Metabolism
Very rare:
Hypoglycemia.
When used in small doses, acetylsalicylic acid reduces the excretion of uric acid. In predisposed patients, this can cause a gout attack. It is important to report suspected adverse reactions after registration of the medicinal product in order to ensure continuous monitoring of the benefit-risk ratio of the medicinal product. Healthcare professionals are encouraged to report any suspected adverse drug reactions to the drug through the national adverse reaction reporting system.
Contraindications
Hypersensitivity to acetylsalicylic acid, other salicylates or excipients in the preparation
Bronchial asthma induced by the intake of salicylates and other NSAIDs;
Erosive and ulcerative lesions of the gastrointestinal tract (in the acute stage)
Hemorrhagic diathesis
Combined use with methotrexate at a dose of 15 mg per week or more
Pregnancy (III trimester) with a daily dose of more than 150 mg
Severe renal failure Severe hepatic failure
Chronic heart failure III-IV functional class according to NYHA classification
Carefully:
With gout, hyperuricemia, because ASA in low doses reduces the excretion of uric acid; it should be borne in mind that ASA in low doses can provoke the development of gout in predisposed patients (with reduced excretion of uric acid)
With a history of gastrointestinal ulcers or gastrointestinal bleeding
With impaired liver function (below class B on the Child-Pugh scale)
With impaired renal function (CC more than 30 ml / min), as well as with circulatory disorders arising from atherosclerosis of the renal arteries, congestive heart failure, hypovolemia, major surgery, sepsis, cases of massive bleeding, since in all of these cases, ASA can increase the risk development of acute renal failure and renal dysfunction.
With bronchial asthma, chronic respiratory diseases, hay fever, nasal polyposis, drug allergies, including the group of NSAIDs (analgesics, anti-inflammatory, antirheumatic drugs)
With a proposed surgical intervention (including minor ones, such as tooth extraction), since ASA can cause a tendency to develop bleeding for several days after taking the drug
For patients with an acute deficiency of glucose-6-phosphate dehydrogenase (G6PD), acetylsalicylic acid can cause hemolysis or hemolytic anemia. Factors that can increase the risk of hemolysis include, for example, high dose, fever, or acute infections;
When used in combination with the following medicinal products (see section "Interaction with other medicinal products"):
- with methotrexate at a dose of less than 15 mg per week;
- with anticoagulant, thrombolytic or other antiplatelet agents
- with NSAIDs and salicylic acid derivatives in high doses;
- with digoxin;
- with hypoglycemic agents for oral administration (sulfonylurea derivatives) and insulin;
- with valproic acid;
- with alcohol (alcoholic drinks in particular);
- with selective serotonin reuptake inhibitors;
- with ibuprofen.
Overdose
A distinction is made between chronic overdose of acetylsalicylic acid, which is accompanied by symptoms mainly from the central nervous system, such as drowsiness, dizziness, confusion or nausea (salicylism), and acute poisoning with acetylsalicylic acid.
A hallmark of acute acetylsalicylic acid poisoning is a severe violation of the acid-base balance. Even when doses are used within the therapeutic range, respiratory alkalosis develops due to rapid breathing. This is offset by increased renal excretion of bicarbonate, which normalizes blood pH. In the case of toxic doses, the level of this compensation is already insufficient, therefore the pH value and the concentration of bicarbonates in the blood fall. Plasma value of РСО2 (partial pressure of carbon dioxide) may temporarily be at normal level. The observed clinical picture corresponds to metabolic acidosis. However, the patient's actual condition is a combination of respiratory and metabolic acidosis. The reasons lie in the restriction of respiratory function, which is caused by toxic doses, and in the accumulation of acid, in part due to a decrease in renal excretion (sulfuric acid, phosphoric acid, salicylic acid, lactic acid, acetoacetic acid, etc.), due to a violation of carbohydrate metabolism. This is compounded by electrolyte imbalance. There is a significant loss of potassium.
Symptoms of acute poisoning
Symptoms of acute poisoning of mild severity (200-400 μg / ml):
In addition to acid-base and electrolyte imbalance (for example, loss of potassium), symptoms such as hypoglycemia, skin rash and bleeding from the gastrointestinal tract, hyperventilation of the lungs, ringing in the ears, nausea, vomiting, impaired vision and hearing, headache were observed. pain, dizziness, and confusion.
In severe poisoning (more than 400 mcg / ml), delirium, tremor, shortness of breath, sweating, dehydration, hyperthermia and coma may develop. ‘
In the case of fatal poisoning, death usually results from respiratory failure.
Poisoning treatment
Therapeutic measures for the treatment of acetylsalicylic acid poisoning depend on the severity, stage and clinical symptoms of poisoning. These may include standard measures to reduce absorption of the active ingredient, monitoring water and electrolyte balance, regulation of abnormal temperatures and ventilation of the lungs.
Treatment focuses on measures to accelerate the elimination of the drug from the body and normalize the acid-base and electrolyte balance. The patient is injected with infusion solutions of sodium bicarbonate and potassium chloride, as well as diuretics. The urine reaction should be alkaline to ensure an increase in the degree of ionization of salicylates and a decrease in the rate of reverse diffusion into the tubules.
It is highly recommended to monitor blood counts (pH value, PCOr, bicarbonate, potassium, etc.). In severe cases, hemodialysis may be required.
Precautions
Particularly careful medical supervision is required:
In the case of the simultaneous use of certain non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen or naproxen, because they can weaken the antiplatelet effect of acetylsalicylic acid Patients should inform their doctor about taking acetylsalicylic acid if they intend to take any NSAIDs (see the section "Interaction with other medicinal products")
The drug should be used as directed by a doctor.
ASA can provoke bronchospasm, as well as cause attacks of bronchial asthma and other hypersensitivity reactions. Risk factors include a history of bronchial asthma, hay fever, nasal polyposis, chronic respiratory diseases, and allergic reactions to other drugs (eg, skin reactions, itching, urticaria).
The inhibitory effect of ASA on platelet aggregation persists for several days after administration, and therefore, there may be an increase in the risk of bleeding during surgery or in the postoperative period. If it is necessary to absolutely exclude bleeding during surgery, it is necessary to completely abandon the use of ASA in the preoperative period, if possible.
Exceeding the dose of ASA is associated with the risk of gastrointestinal bleeding.
Overdose is especially dangerous in elderly patients.
In severe forms of glucose-6-phosphate dehydrogenase deficiency, ASA can cause hemolysis and hemolytic anemia. Factors that can increase the risk of hemolysis are fever, acute infections, and high doses of the drug.
At low doses, acetylsalicylic acid reduces the excretion of uric acid, which can cause gout attacks in predisposed patients.
Medicines containing acetylsalicylic acid should not be prescribed to children and adolescents for the treatment of viral infections, with or without fever, without consulting a doctor. With some viral diseases, especially with influenza A, influenza B and chickenpox, there is a risk of developing Reye's syndrome, a very rare but life-threatening disease that requires emergency medical attention. This risk may increase with concomitant administration of acetylsalicylic acid; however, no causal relationship has been established. A symptom of Reye's syndrome can be persistent vomiting in the above diseases.
Influence on the ability to drive a car / moving machinery
Taking the drug Aspirin® Cardio does not affect the ability to drive a car / moving machinery.
Interaction with other medicinal products
Strengthening the action up to an increased risk of side effects:
Anticoagulants / Thrombolytic Drugs: Acetylsalicylic acid may increase the risk of bleeding when taken prior to initiation of thrombolytic drug therapy. For this reason, attention should be paid to the possible presence of signs of external or internal bleeding (for example, bruising) in patients for whom thrombolytic therapy is planned.
Antiplatelet drugs (eg, ticlopidine, clopidogrel): bleeding time may increase.
Other non-steroidal anti-inflammatory drugs (NSAIDs) and antirheumatic drugs in general: increased risk of gastrointestinal ulceration and bleeding.
Systemic glucocorticoids (with the exception of hydrocortisone, used as replacement therapy for Addison's disease): an increased risk of side effects from the gastrointestinal tract.
Alcohol: increased risk of gastrointestinal ulceration and bleeding.
Digoxin: increased plasma concentration.
Anti-diabetic drugs: Blood glucose levels may be low.
Methotrexate: a decrease in the level of excretion of the drug from the body and displacement by salicylates from the sites of protein binding.
Valproic acid: displacement by salicylates from protein binding sites.
Selective serotonin reuptake inhibitors (SSRIs): increased risk of gastrointestinal bleeding due to synergistic effect.
Weakening action:
Aldosterone antagonists (spironolactone and canrenoate);
Loop diuretics (such as furosemide);
Antihypertensive drugs (especially ACE inhibitors);
Uricosuric drugs (eg, probenecid, benzbromarone).
NSAIDs: Concomitant use (on the same day) of certain NSAIDs (except for acetylsalicylic acid), such as ibuprofen or naproxen, can weaken the irreversible antiplatelet effect of acetylsalicylic acid. The clinical significance of this interaction is unknown. Treating patients with an increased cardiovascular risk with certain NSAIDs, such as ibuprofen or naproxen, may reduce the cardioprotective effect of acetylsalicylic acid (see PRECAUTIONS section).
Patients should not take Aspirin® Cardio at the same time as any of the above substances, unless their combined use is prescribed by a doctor.
Pregnancy and lactation
Pregnancy
Inhibition of prostaglandin synthesis can have an adverse effect on pregnancy and / or embryo-fetal development. Evidence from epidemiological studies raises concerns about the increased risk of spontaneous abortion and congenital malformations following the use of an inhibitor of prostaglandin synthesis in early pregnancy. It is believed that this risk increases with increasing dose and duration of therapy.
In the framework of previous experience with the use of ASA in daily doses from 50 mg to 150 mg during the second and third trimesters of pregnancy, no data were obtained indicating inhibition of labor, an increase in the predisposition to the development of bleeding, or premature closure of the ductus arteriosus.
There is no information available regarding the use of daily doses in the range of 150 mg to 300 mg. During the last trimester of pregnancy, the administration of analgesic doses of ASA can (as a result of inhibited prostaglandin synthesis) cause prolonged pregnancy, inhibition of labor and, starting from the 28th 30th week of pregnancy, premature closure of the ductus arteriosus. The use of these doses can also increase the predisposition to the development of bleeding in both the mother and the child, as well as increase the incidence of intracranial hemorrhage in premature infants, if ASA is administered shortly before delivery.
1st and 2nd trimesters
During the first and second trimesters of pregnancy, Aspirin® Cardio 100 mg can be prescribed in daily doses up to 300 mg of ASA only if there is a strict indication for this. The decision on the need for therapy, as well as its duration and dose, is determined by the attending physician.
3rd trimester
Likewise, the administration of a daily dose of up to 150 mg of ASA during the third trimester of pregnancy can only be prescribed if there is an urgent indication. The decision on the need for therapy, as well as its duration and dose, is determined by the attending physician.
During the last trimester of pregnancy, the use of Aspirin® Cardio 100 mg in a daily dose of 150 mg ASA or more is contraindicated (see section "Contraindications").
Lactation
Acetylsalicylic acid (active ingredient) and its metabolites in small quantities pass into breast milk. To date, no adverse effects on the infant have been reported, so there is no need to interrupt breastfeeding if the daily dose does not exceed 150 mg.
Terms of dispensing from pharmacies
Without recipe.
Manufacturer's name and address
Marketing Authorization Holder:
Bayer Consumer Care AG, Switzerland
Bayer Consumer Care AG, Switzerland;
Produced by:
Bayer Bitterfeld GmbH, D-06803 Bitterfeld-Wolfen, Germany manufactured by Bayer Bitterfeld GmbH, D-06803 Bitterfeld-Wolfen, Germany
Every year, cardiovascular diseases such as cerebral stroke, myocardial infarction, angina pectoris, claim the lives of many people of different ages. Scientists from different countries are working on creating drugs that can prevent the development of diseases of the heart and blood vessels, as well as reduce their symptoms. Among such drugs, the drug "Aspirin Cardio", developed by the leading German company Bayer, has gained particular popularity.
The history of the drug
The history of the creation of the drug "Aspirin Cardio" is inextricably linked with the world-famous drug "Aspirin", which is well studied and with proven effectiveness. Acetylsalicylic acid was discovered at the end of the 19th century at the same famous Bayer plant and patented as a drug with analgesic and anti-inflammatory activity. And only half a century later, new possibilities of this acid were discovered to have an antiaggregatory effect on blood platelets. Numerous clinical studies using aspirin have shown the high effectiveness of this drug in the treatment of myocardial infarction and coronary heart disease. It has been proven that this drug in small doses has a better effect than the usual tablet with a norm of 500 mg of active ingredient. However, there has been a negative effect of acetylsalicylic acid on the digestive tract, in which it can cause irritation and damage to the mucous membrane, which leads to its ulceration. To remove the negative consequences of taking the drug "Aspirin", the composition of the drug was improved by the technologists. The tablets of the new drug began to be coated with a multilayer lacquer coating with acid-resistant properties. The dosage of the active ingredient was also reduced. A new trade name for the drug was invented - "Aspirin Cardio". In Russia, the drug is also registered under this brand name and is prescribed for patients with heart disease, blood vessels and hypertension.
Dosage form and composition of the drug
As in the whole world, the dosage form of the drug "Aspirin Cardio" is represented by round, biconvex tablets. Outside, the tablet is coated with a white enteric coating.
Due to the soluble shell, Aspirin Cardio has a slightly different composition than its predecessor, Aspirin, from Bayer. The active ingredient was acetylsalicylic acid at a dosage of 100 mg and 300 mg. This is a significantly lower content of active substance in a dosage unit than in the usual Aspirin. Manufacturers use other ingredients to form the tablet, but they do not have any therapeutic effect on the body. These are powdered cellulose and corn starch.
A more complex composition has a three-layer tablet coating. It consists of talc, sodium lauryl sulfate, triethyl acetate, a copolymer of methacrylic acid and acrylic acid ethyl ester. It also contains an emulsifier - Tween 80. Such a complex composition of the shell allows the tablet to pass through the parts of the stomach intact, and only in the intestine does its dissolution begin.
The drug "Aspirin Cardio", analogues
As mentioned earlier, the tablets of the drug "Aspirin Cardio" are original, first patented by German manufacturers. Recently, more and more similar drugs appear on the pharmaceutical market, similar in composition, therapeutic effect and relative safety. The drug "Aspirin Cardio" has analogues with and without a protective shell. For uncoated tablets, special antacid components are used, which temporarily protect the gastric mucosa from the harmful effects of acid.
Treatment of diseases of the cardiovascular system with drugs "ThromboASS", "Aspinat", "Cardiomagnil", "Aspinat 300", "Aspikor", "AspinatCardio", "Mikristin", "Acenterin", "Taspirin", "Acecardol", "Kolfarit" "speaks of their analogy with Aspirin Cardio. All these drugs have the same active component - acetylsalicylic acid, only in different amounts. The other ingredients of the tablet may differ, but they should not affect the dynamics and kinetics of the main substance.
If the patient is faced with the question of which drug to choose: "ThromboASS" or "Aspirin Cardio", you need to know their similarities and differences. According to the international classification, both drugs belong to the group of non-steroidal anti-inflammatory drugs, the indications for use are the same, the tablets are coated with a protective coating, which indicates their safety. These two products are of European origin, only the Austrian drug "ThromboASS", and the German "Aspirin Cardio" drug. According to the composition of the tablets, there are differences in excipients, there are more of them in the "ThromboASS" preparation. Various ingredients are found in the shells of these drugs. In addition, one should not forget that prices for generic analogues are an order of magnitude lower than for the original product. Therefore, the drug "ThromboASS" is considered a more affordable drug for unprotected segments of the population, it can often be found in a pharmacy.
If there is a choice: "Cardiomagnet" or "Aspirin Cardio", it should be noted that these analogs belong to the same classification group of non-steroidal anti-inflammatory drugs. Only the first also belongs to the group of antacids. Their active component is the same, but the other components are different. Unlike the Aspirin Cardio drug, the Cardiomagnyl tablets are not coated. To reduce the irritating effect, the antacid component of magnesium hydroxide was introduced into its composition, which envelops the walls of the stomach, promotes the production of mucous secretions.
But do not self-medicate, only the attending doctor must decide which drug to take, especially if there are problems with digestion.
The mechanism of action of the drug
The original drug "Aspirin Cardio" contains information on pharmacodynamic and pharmacokinetic characteristics. How does this medicine work on the human body?
The main active substance - acetylsalicylic acid - is able to block the enzyme system responsible for the synthesis of prostaglandins, which cause inflammatory processes in cells. The analgesic and antipyretic effect of the drug is carried out by reducing the sensitivity of the cells of the nervous system, this is due to a decrease in the number of mediators of inflammatory reactions. The ability to provide anti-inflammatory, antipyretic, analgesic effect of the drug "Aspirin Cardio" is significantly lower than that of the simple drug "Aspirin" with a dosage of 500 mg.
The second main feature of the acid is to prevent platelets from sticking to each other or to the wall of blood vessels. It is carried out due to inhibition of the production of thromboxanes in blood cells responsible for coagulation. The drug "Aspirin Cardio" has a long-term effect, the use of its single dose helps to reduce platelet aggregation for a whole week.
Acetylsalicylic acid in the composition of the tablet enhances the dissolution of fibrin clots in the blood plasma, while the concentration of coagulating factors dependent on vitamin K decreases. This explains the ability of the drug to have a fibrinolytic effect.
The acid from the tablet is released into the cavity of the duodenum, this is facilitated by the alkaline reaction of the intestine, in which the protective shell dissolves. Then the active substance is completely absorbed into the bloodstream and spreads to the diseased organs. It is excreted from the body by the kidneys in the form of acetylsalicylic acid metabolites.
What diseases are treated with this remedy?
Before taking the drug "Aspirin Cardio", the instructions for the use of this medication must be read by the patient without fail. It contains all the information you need.
An important section of the instructions for the "Aspirin Cardio" - "Indications for use", which states that this drug is used for all diseases associated with excessive blood clots. It is prescribed as a blood thinning agent for the treatment and prevention of coronary heart disease in its various forms, myocardial infarction in diabetes, high blood pressure, overweight, stable and unstable angina pectoris. The medicine "Aspirin" helps to prevent the onset of heart attacks and strokes, prevents the formation of blood clots in the vessels, which already contain cholesterol plaques on their walls. For prophylactic purposes, it is used in surgical interventions to avoid thrombus formation.
Multifunctional drug "Aspirin Cardio", its indications apply to the nervous system, when cerebral blood flow is disturbed, ischemic conditions of the brain. It is widely used as a prophylactic agent for venous thrombophlebitis of the extremities, with blockage of the artery of the lung or its infarction. All of the above conditions are accompanied by increased blood viscosity caused by clumping of platelet cells.
Rules for taking the drug
The way of using this or that drug depends on its characteristics. So, the medicine "Aspirin Cardio" should be drunk before meals, so that food does not interfere with the absorption of the active substance in the intestine. It is very important to swallow the pill whole so as not to damage its protective shell. Only at the first signs of unstable angina pectoris is the tablet recommended to be crushed so that the drug is better absorbed and acts faster. Drink with plenty of water.
If the patient is prescribed "Aspirin Cardio", how to take it in various conditions, the section of the instruction "Methods of use" will tell you. This section details the dosage of the drug for each indication.
The instruction in the package of the drug "Aspirin Cardio" usually sets the daily dosage, which is taken at one time. For prophylactic purposes, to prevent the acute development of an infarction state of the heart muscle, it is 100 mg or 300 mg each, then the reception and non-reception days alternate.
In order to prevent the development of repeated infarction conditions, various types of angina pectoris, strokes, thromboembolism, after surgical operations on the veins, daily dosages of 100-300 mg are used. After a myocardial infarction within a month, the daily dosage is 200-300 mg.
For prophylactic purposes, the drug is prescribed for long-term use, while it is necessary to periodically take blood coagulation tests to control the action of acetylsalicylic acid. The doctor should cancel the drug after examining the results of a blood test.
A little about side effects
Sometimes from patients taking drugs "Aspirin Cardio", reviews come in about various changes in health. The organs of the gastrointestinal tract, hematopoietic, nervous, and urinary systems are most affected by acetylsalicylic acid. Allergic reactions may occur.
Means "Aspirin Cardio", reviews of people about its effect on the digestive system, this is confirmed, can cause side reactions in the form of nausea, vomiting, high acidity, pain in the abdomen. Sometimes ulceration of the mucous membrane in the stomach or duodenum, abnormal liver function may occur. There are isolated cases of bleeding in the gastrointestinal tract.
The risk of hemorrhage is associated with the thinning effect of the drug on blood cells, which manifests itself in the form of bleeding in the nose, gums, urinary and genital organs, hematomas on the skin. As a result of prolonged blood loss, iron deficiency develops in the body, leading to a decrease in hemoglobin levels.
The human body reacts differently to the drug "Aspirin Cardio", the instructions for use include a list of allergic reactions observed in various systems. These can be asthmatic phenomena in the bronchi, swelling of the mucous membranes of the nose, eyes, allergic rhinitis, manifestations on the skin in the form of itching, rashes. In the worst cases, shock develops.
There are times when this drug is capable of causing headache, fainting, hearing impairment, which indicates its effect on the nervous system.
The kidneys can also suffer from the action of acetylsalicylic acid, resulting in their failure.
Are there any cases of overdose?
If the patient has not read the instruction attached to the "Aspirin Cardio" tool, reviews of an overdose of this drug may follow immediately. So, if the therapeutic dose of this drug is exceeded, the body becomes poisoned with salicylates, which the liver simply cannot quickly neutralize.
Distinguish between primary poisoning, when an overestimated dose was taken in a single dose, and chronic, which occurs with prolonged intake of a large amount of medicine, it does not appear immediately.
Chronic poisoning is difficult to diagnose, but acute poisoning with a large dose of acetylsalicylic acid is characterized by dizziness, hearing impairment, sweating, gag reflex, electrolyte and acid-base imbalances. All these manifestations disappear when the dose of the drug in the blood decreases to the desired limits.
In severe cases, breathing disorders, cardiac activity, increased pressure, renal failure, bleeding of the mucous membranes may occur.
When the first signs of poisoning appear, the person should be immediately hospitalized in a hospital, where his stomach will be washed without fail. Depending on the condition, the patient is given activated charcoal, forced stimulation of urination with alkalinization of urine, which leads to a greater excretion of acid, blood purification using hemodialysis can be prescribed.
Who is the drug contraindicated for?
Doctors do not prescribe the medicine "Aspirin Cardio" to all patients; patient reviews of suspicious symptoms that have appeared also serve as a reason for canceling this drug. There are diseases for which this medicine should not be taken. These can be allergic reactions to the active component of Aspirin Cardio or other drugs from its group, a reduced number of platelets in the blood, asthmatic attacks (to acetylsalicylic acid), low hereditary blood clotting, increased bleeding, ulceration of the gastrointestinal tract mucosa, liver in a state of cirrhosis, renal failure.
Has the drug "Aspirin Cardio" contraindications for pregnant women in the first and third trimesters, but in the second it is used only in special cases as prescribed by a doctor. Acetylsalicylic acid crosses the placenta into the blood of the fetus and can cause various disorders in the development of the embryo, which indicates its toxicity. In the later stages, taking the drug can cause a decrease in contractions, profuse blood loss during and after childbirth, cerebral hemorrhage in a child.
It does not interfere with the use of this medication with the formation of stones in the kidneys, bladder or ducts, asthmatic conditions, the deposition of uric acid salts in various tissues and its increased content in the blood, alcohol abuse, hepatitis, after a gastrointestinal ulcer. Reception is contraindicated in children under 18 years of age.
High degree of safety and effectiveness of the drug
In most cases, taking the drug is accompanied by good tolerance and high rates of therapeutic action. After all, the tablets have passed numerous preclinical tests on animals, and only after the obtained positive results were clinical trials on humans carried out.
The merit of the manufacturers of the drug "Aspirin Cardio" is the development of a protective shell that prevents the tablet from dissolving in gastric juice, and thereby protects the mucous membrane from the irritating action of acetylsalicylic acid. This significantly reduces the incidence of systemic side effects from the digestive system, compared to taking unprotected aspirin tablets. The unwanted symptoms are more local in nature.
Another advantage of the drug "Aspirin Cardio" is its small dosage, which to a lesser extent causes side effects on the mucous membranes. So, a dose of 100 mg of acetylsalicylic acid, with its prolonged use, is capable of reducing the synthesis of platelet enzyme, and at the same time does not at all inhibit the formation of prostaglandin mediators. That is why small dosages are recommended to be prescribed for diseases of the cardiovascular system, accompanied by an increased risk of blood clots.
Pharmacology does not stand still and every year offers more and more advanced drugs to fight diseases or prevent pathological conditions. Many people, especially the elderly, are interested in the benefits and harms of Cardioaspirin. This is a popular medication based on acetylsalicylic acid. In addition to the properties characteristic of everyone known, it prevents the formation of blood clots. Before you start using the drug on an ongoing basis, you should familiarize yourself with its features.
Description of the drug
Cardioaspirin is produced by the German company Bayer and belongs to anticoagulants, antiplatelet agents. Acetylsalicylic acid acts as the main component. In addition, auxiliary substances appear in the composition, so you should not think that the body of a person who normally tolerates aspirin will also react to Aspirin Cardio.
Solid round tablets may contain 100 or 300 mg of active ingredient. They are enclosed in a protective shell that reduces the risk of heartburn and other unpleasant consequences. Despite the fact that the medication is dispensed in pharmacies without a doctor's prescription, any attempts to self-medicate are dangerous to health. Therapy based on Aspirin Cardio should be started only after consultation with a specialist.
Mechanism of action
Without going into chemistry and anatomy, we can say that acetylsalicylic acid is capable of suppressing the action of certain enzymes and inhibiting the synthesis of a number of substances. As a result, pain and inflammation disappear, blood vessels dilate, platelets do not form clots, blood clots. These properties are also characteristic of Aspirin Cardio. Taking it regularly reduces the risk of blood clots and, consequently, the risk of ischemic heart attacks and strokes.
In addition, numerous studies have shown that Aspirin Cardio has other effects:
- the drug does not allow red blood cells to combine into groups, which is used for certain diseases of the blood and blood vessels;
Advice
The drug has many effective analogues, but Aspirin Cardio is produced exclusively by the German manufacturer Bayer. If the packaging shows another country or another manufacturer, it is a fake, and it is better not to purchase it.
- the drug reduces the sensitivity of nerve endings, due to which pain is relieved;
- centers of regulation of body temperature become less sensitive, which allows you to relieve fever.
Aspirin Cardio tablets are coated with a special coating, which is why the main substance is released not in the stomach, but in the duodenum. Accordingly, the risk of gastric bleeding is reduced several times in comparison with ordinary aspirin.
Indications for use
Basically, Cardioaspirin is prized for its ability to prevent blood clots. It is usually prescribed when the risk of blood clots is increased due to its increased viscosity. In addition, there is still a rather impressive list of indications for the use of the drug:
- As a prophylaxis for myocardial infarction in the presence of risk factors: high sugar, cholesterol, blood fats, and hypertension.
- Risk of interruption or impairment of the supply of blood, and therefore oxygen, to heart and brain cells.
- Stable and unstable forms of angina pectoris in the presence of intermittent pain syndrome.
- Stroke prevention. Aspirin Cardio is indicated even for short-term circulatory disorders in the brain.
- Often the drug is recommended for long-term use of oral contraceptives or forced immobility of the limbs. Cardioaspirin prevents the development of thrombosis and subsequent thromboembolism.
- Sometimes the composition is prescribed after the transferred operations on the vessels.
Sometimes Cardioaspirin is also used as an antipyretic, anti-inflammatory agent. But for such situations, it is better to use substances of a more narrowly targeted action.
Features of reception
The decision on how the therapy will be organized should be made only by the attending physician. He sets the dosage and frequency of drug use, the duration of the therapeutic course. The specialist should be aware of what other medications are being taken or have recently been taken by the patient.
You should also remember about the following features of Aspirin Cardio:
- The drug is capable of provoking an allergy attack or bronchospasm. It is drunk with increased caution in cases of bronchial asthma, hay fever, and a history of allergies to any medications.
- If an operation is to be performed, you must refuse to take it at least 2-3 weeks before the date. Otherwise, there is a risk of bleeding.
- Exceeding the recommended dosages can provoke internal bleeding.
The missed pill from the course should be drunk as soon as possible. But you should not do this if there is very little time left until the next tablet on the schedule. Otherwise, a double dose will be taken, and this is fraught with negative consequences.
Pregnancy and breastfeeding are direct contraindications to the use of Aspirin Cardio. If, for medical reasons, it is impossible to refuse the drug, the course and dosage must be prescribed by the doctor.
As a rule, experts give the following instructions:
- In the first trimester of pregnancy, the drug is strictly prohibited. Even a daily therapeutic dose of acetylsalicylic acid is dangerous to the fetus.
- In the second trimester, you should not take more than 150 mg of Cardioaspirin per day. It is desirable that this dose be one-time, not systematic.
- If in the third trimester, as in the second, Cardioaspirin can be taken only once. In this case, the permissible dose is not more than 300 mg of the active substance. Otherwise, the drug can lead to blood thinning in the fetus, delaying labor.
- At the end of pregnancy, Aspirin Cardio is prohibited. It can cause uterine bleeding in a woman or cerebral hemorrhage in an infant.
- Breastfeeding is discontinued with prolonged therapy. A single dose of the drug does not have a negative effect on the child, because enters milk and the baby's body in a minimal volume.
Even if all of the above rules are followed, Cardioaspirin can negatively affect the development of the fetus or newborn baby. The dosage and frequency of administration can only be determined by a doctor and only for medical reasons. Otherwise, the woman is taking unnecessary risks.
Contraindications
There are other conditions, in addition to pregnancy and breastfeeding, that are contraindications to taking the drug based on acetylsalicylic acid.
- Allergy to the main component and its derivatives.
- The patient's age is up to 18 years.
- Bronchial asthma, which arose while taking Cardioaspirin or its analogues.
- Erosion on the mucous membrane of the digestive system, bleeding.
- Diathesis of hemorrhagic type.
- Postponed hemorrhagic stroke.
- Pathological processes in the liver and kidneys (by the decision of the doctor).
- Chronic problems of myocardial functioning.
- The use of a number of drugs.
Despite the fact that reviews about taking Aspirin Cardio are mostly positive, the drug is capable of provoking the development of side effects. If any negative changes in the condition appear, you should immediately contact your doctor. Dose adjustment or treatment plan revision may be needed.
Aspirin Cardio instructions for use prescribe to take for blood thinning, prevention and treatment of heart disease. Cardiologists confirm that these 100 and 300 mg tablets help in the treatment of angina pectoris and the prevention of strokes and heart attacks.
Release form and composition
The active component of the tablets is acetylsalicylic acid. The drug is available in a dosage of 100 and 300 mg. Cellulose and corn starch are used as auxiliary substances.
pharmachologic effect
Once in the gastrointestinal tract, the active substance is converted into salicylic acid. Acetylsalicylic acid inhibits platelet aggregation by blocking the synthesis of thromboxane A2. Violates the mechanism of creation of cyclooxygenase.
The drug has anti-inflammatory and antipyretic effects. Also, the medicine is used for arthritis and osteoarthritis, flu and colds.
The maximum concentration of acetylsalicylic acid - after 20 minutes, after taking, salicylic acid - after an hour. If a dosage form is used, coated with a coating that is soluble in the intestine, then the absorption of the active substances occurs later, not in the stomach. The effect of the drug is prolonged.
Indications for use
What does cardio help with? Tablets are prescribed:
- stable angina pectoris, unstable angina pectoris, including with suspected development of acute myocardial infarction;
- stroke prevention, including patients with transient cerebrovascular accident;
- prevention of thromboembolism after aortocoronary and arteriovenous bypass grafting, endarterectomy and angioplasty of the carotid arteries, angioplasty and stenting of coronary arteries, other invasive interventions or operations on the vessels;
- prevention of deep vein thrombosis;
- prevention of transient disorders of cerebral circulation;
- prevention of thromboembolism of the pulmonary artery, its branches, including the state of prolonged immobilization after major surgical operations;
- primary prevention of acute myocardial infarction (in the presence of such risk factors as hyperlipidemia, diabetes mellitus, arterial hypertension, old age, smoking, obesity), repeated myocardial infarction.
Instructions for use
Aspirin cardio is recommended to be used once a day, this medicine is suitable for long-term, systematic use. The exact dose and duration of therapy is determined by the attending physician after a comprehensive examination of the patient. Since after oral administration, the drug is completely absorbed from the gastrointestinal tract, the tablets must be used before the main meal, drinking plenty of water.
During the primary prevention of heart attack, the drug is taken at 100 mg per day or 300 mg every other day.
In order to prevent recurrent heart attacks, stable and unstable angina pectoris, the drug is used at 100-300 mg per day.
With the development of unstable angina pectoris, the drug is prescribed at 100-300 mg. If you suspect the development of an acute heart attack, the patient should take the first tablet of the medicine as soon as possible. The medicine should be chewed in order to accelerate the absorption process and provide a therapeutic effect.
In order to prevent strokes and disorders of cerebral circulation, as well as the development of thromboembolism in the period after surgery, the drug is taken at 100-300 mg per day.
For the prevention of deep vein thrombosis and thromboembolism - 100-200 mg per day or 300 mg every other day.
If you miss taking the drug, the next pill should be taken as soon as possible. Further medication should be taken in the usual way. In the event that a long time has passed since the moment of passing and the time for taking the next pill is approaching, you should not double the dosage.
Read also the instructions for use of a close analogue. How to take it to prevent stroke.
Contraindications
- liver and kidney disease;
- acute heart failure;
- diathesis;
- asthma;
- drug allergy.
The drug should be used exclusively as directed by a doctor.
Aspirin cardio should not be taken if an ulcer has worsened or a person has suffered a hemorrhagic stroke. It is not prescribed for those who have been found to be hypersensitive to aspirin or who have been diagnosed with renal, hepatic, or heart failure.
The medicine is not prescribed for patients under 18. It is not recommended to drink Aspirin cardio in the 1st and 3rd trimesters of pregnancy.
Side effects
- allergic skin reactions;
- anemia, thrombocytopenia, agranulocytosis, leukopenia;
- various bleeding;
- headache and dizziness;
- hepatitis, pancreatitis, pain and bloating, lack of appetite, stomach ulcer.
special instructions
There was no effect on the ability to drive a car or other mechanisms.
To check the effect of the use of Aspirin Cardio, a coagulogram is prescribed (people suffering from problems associated with blood clotting are familiar with this study very well). If the result is satisfactory, the treatment is either weakened or stopped completely - at the discretion of the attending physician.
Features of taking Aspirin Cardio to combat fever or headaches must additionally be discussed with a specialist.
When taking aspirin, one should keep in mind the fact that its antiaggregatory effect persists for several days, therefore, when planning a surgical intervention, it is necessary to stop taking the drug during this period.
Drug interactions
Aspirin Cardio enhances the effect of the following drugs, while taking it, you should consult a doctor: methotrexate, heparin, anticoagulants, thrombolytic, antiplatelet agents, MAO inhibitors, digoxin, valproic acid, salicylic acid derivatives, diuretics, ethanol.
The drug weakens the effect of: diuretics, ACE inhibitors, benzbromarone, probenecid. Ibuprofen and systemic corticosteroids reduce the effectiveness of acetylsalicylic acid. Particular care should be taken by patients with diabetes mellitus taking hypoglycemic agents.
Analogues of the drug Aspirin Cardio
Analogs are determined by structure:
- Thrombolic cardio.
- Aspeter.
- Magnikore.
- Aspeckard.
- Godasal.
- Aspenorm.
- Thrombo Ass.
- Acecor cardio.
- Asaphen.
- Asprovit.
- Acetylsalicylic acid.
- Lospirin.
- Upsarin UPSA.
- Aspirin.
- Polocard.
- Aspimag.
Analogs have a similar effect:
- Trombonet.
- Gendogrel.
- Axanum.
- Clopidal.
- Disgren.
- Cropied.
- Plavix.
- Avix.
- Platogrill.
- Lopired.
- Ipaton.
- Pingel.
- Brilinta.
- Effient.
- Agrenox.
- Cardogrel.
- Ilomedin.
- Thrombo Ass.
Which is better: Aspirin or Aspirin Cardio?
Not so long ago, scientists proved that one fourth of the standard dose of acetylsalicylic acid is enough to achieve the required therapeutic effect.
What is the difference? The main thing that makes Aspirin different from Aspirin Cardio is the amount of active ingredient per tablet. This difference means that less harm will be done to the body than a 325 mg dose.
Which Aspirin is Best for the Heart? It is believed that Cardio is preferable.
Which is better: Thrombo Ass or Aspirin Cardio?
Thrombotic Ass is a synonym for Aspirin Cardio, therefore, there is no significant difference in the action of one or the other. Only cost can differ.
Vacation conditions and price
The average cost of Aspirin Cardio (300 mg tablet No. 20) in Moscow is 90 rubles. Available without a prescription.
Storage of the medicine should be carried out in a dark place, protected from direct sunlight at a temperature not exceeding 25 degrees.
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