Hemorrhoids are a common disease often caused by a sedentary lifestyle, unhealthy diet, drinking alcohol, and insufficient physical activity. These factors have a negative impact on the functioning of the body, in particular on the vessels of the intestine and rectum. Pathology also occurs as a result of congenital disorders associated with the weakness of the intestinal wall.
Hemorrhoids show a number of unpleasant symptoms. These include itching, burning, and soreness that gets worse over time. Signs of the disease negatively affect the quality of life, but many patients are in no hurry to see a doctor with such a delicate problem. But in the absence of therapy, the disease progresses, causing serious consequences.
Modern medicine offers many remedies for this problem. Today in pharmacies you can find various ointments and rectal suppositories that will help relieve pain and prevent complications. One of the best drugs is Procto-Glivenol.
The drug has a combined effect, it is used for local exposure. The active substances that make up the ointment and rectal suppositories have an effect directly on the focus of the inflammatory process. The medicine has an analgesic, venotonic and anti-inflammatory effect, due to which it is possible not only to relieve unpleasant symptoms, but also to have a therapeutic effect.
Procto-Glivenol belongs to the group of venotonic and anti-inflammatory drugs with analgesic effects. Procto-Glivenol helps to restore the elasticity of the vascular walls in a short time, helps relieve pain and discomfort in the anus.
Forms, composition and price
Due to the presence of two different forms of release, each patient can choose the ideal option for himself, depending on the severity of the symptoms and the severity of the disease.
The medicine has two forms of release:
As active substances of Procto-Glivenol cream, the composition includes lidocaine hydrochloride and tribenoside. Additional components are sorbitol, cetyl alcohol, stearic acid, liquid paraffin, cetomacrogol, sorbitol stearate and others.
Each rectal suppository contains:
- two active ingredients: tribenoside and lidocaine;
- excipients witepsol E85 and witepsol W35.
The average cost of Procto-Glivenol rectal cream is 322 rubles. The price of packing suppositories is about 337-410 rubles.
Pharmacological properties
Procto-Glivenol is an anti-hemorrhoid agent with an analgesic effect. The combined effect of lidocaine and tribenoside helps to reduce painful sensations and reduce the inflammatory process.
Tribenoside is an active ingredient that is part of suppositories and ointments. It helps to reduce the permeability of the vascular walls, reduce stagnation in the veins. In addition, tribenoside inhibits the activity of histamine and serotonin, negatively affects the synthesis of bradykinin. However, it has no effect on epinephrine and norepinephrine.
Due to the presence of tribenoside in the composition of the ointment and suppositories, the medicine quickly helps to eliminate congestion in the veins. The active substance helps to eliminate the inflammatory process, relieves swelling of soft tissues and has an analgesic effect.
Lidocaine is a well-known pain reliever that is widely used in many fields of medicine, including dentistry. The substance blocks sodium channels and stabilizes cell membranes. As a result, the process of conducting nerve impulses slows down.
When using suppositories, the maximum concentration of active substances in the blood is reached two hours after use. The bioavailability of the drug is about 40%.
To achieve maximum effectiveness, the ointment is recommended to be applied to the mucous membrane, since the active components reach the focus of the inflammatory process much faster. The drug is excreted naturally through the kidneys.
Indications and contraindications
Procto-Glivenol is used in the treatment of external and internal forms of mild to moderate hemorrhoids. The drug is also prescribed for the treatment of patients with a severe form of the disease, when it is not possible to carry out surgical treatment due to the presence of contraindications.
The dosage of the drug is selected by the attending physician, depending on the characteristics of the pathology. The cream comes with a special nozzle, with which you can inject the agent into the lower intestine. One package of cream is enough for about 25 procedures.
In cases where there is no improvement after the use of Procto-Glivenol, you should contact your doctor who will adjust the therapy regimen. The drug can be used in combination with other drugs, there are no cases of negative reactions due to interaction with drugs of other groups.
Procto-Glivenol also has a number of contraindications, which can be divided into two types: absolute and relative. The first group includes:
- Liver dysfunction.
- First trimester of pregnancy.
- Intolerance of the constituent substances.
In the presence of these contraindications, the drug is strictly prohibited to use. Relative ones include:
- period of breastfeeding;
- 2nd and 3rd trimester of pregnancy.
Instructions for use
Before starting treatment, you should carefully study the instructions for use. Despite the fact that the drug is dispensed without a prescription, it is recommended to consult a doctor, as it has a number of contraindications.
Candles
The therapy rules are as follows:
Ointment
The ointment is applied to the anus or anal mucosa using special applicators in the morning and evening. The dosage for mild severity of the disease can be reduced to one procedure, which is done before going to bed.
For the effectiveness of therapy, patients should follow a number of rules:
During pregnancy and lactation
Unlike many drugs, Procto-Glivenol can be used in the 2nd and 3rd trimester of pregnancy. But at the same time, it is strictly forbidden to use it in the early stages of pregnancy. This is due to the fact that the active components of the drug penetrate into the bloodstream and can have a negative effect on the process of formation and development of the fetus.
From the second trimester, the drug can be prescribed for the treatment of hemorrhoids in a pregnant woman. However, it should be used with caution and only under the supervision of the attending physician. The specialist will select the required dosage and determine the duration of therapy. Self-medication is strictly prohibited, as it can harm the fetus.
If it is necessary to use Procto-Glivenol during breastfeeding, when prescribing, the doctor must take into account the risk to the baby. Active substances can pass into breast milk. That is why a woman should refuse to breastfeed.
Side effects
Procto-Glivenol causes side effects in rare cases. The drug is very popular not only because of its ease of use. It has a minimal amount of side effects. Among them, anaphylactic shock, bronchospasm, facial swelling, and cardiovascular disorders are distinguished.
As a result of the presence of individual intolerance, negative symptoms from the skin can be observed, such as hives, itching, irritation and burning. Signs in certain cases extend not only to the area of \u200b\u200buse of the drug, but also for it.
For several years of using Procto-Glivenol, specialists have not identified cases of overdose. But if the cream or suppository gets inside, the stomach should be washed. To eliminate the occurrence of unpleasant symptoms, it is recommended to take enterosorbents.
special instructions
In cases where no improvement occurs after the use of the drug or the occurrence of other negative symptoms not associated with hemorrhoids is observed, you should consult a doctor to clarify the diagnosis and re-diagnose.
During the period of therapy, you should follow the rules of intimate hygiene and regularly wash the anus area. In order to avoid excessive stress, measures should be taken to maintain a soft consistency of feces.
When using the drug in the indicated dosages, mental reactions are not reduced. The drug also does not have a negative impact on the ability to drive vehicles and perform work associated with precise mechanisms.
Analogs
There are no structural analogues of the drug. If it is impossible to use Procto-Glivenol, the drug can be replaced with a drug with a similar effect. The most effective analogues are:
When using analogs, you should carefully study the instructions for use and observe the indicated dosages. It is also necessary to take into account the presence of contraindications.
Last updated description by manufacturer 23.09.2016
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Active substance:
ATX
Pharmacological groups
Nosological classification (ICD-10)
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Composition
Description of the dosage form
Solid rectal suppositories, torpedo-shaped, without cracks, slightly greasy to the touch, yellowish-white in color, with a slight specific odor.
pharmachologic effect
pharmachologic effect - local anesthetic, angioprotective, antihemorrhoidal.Pharmacodynamics
Combined anti-hemorrhoidal agent. Tribenoside reduces capillary permeability and improves vascular tone; antagonistically affects some endogenous substances that act as mediators in the development of inflammation and pain.
Lidocaine has a local anesthetic effect. The drug causes a rapid relief of symptoms caused by hemorrhoids (pain, itching and skin tightness).
Pharmacokinetics
The systemic bioavailability of tribenoside coming from the suppository reaches 30% of the amount absorbed when the drug is taken orally (in the form of capsules). Achievement of C max in plasma of 1 μg / ml (tribenoside + metabolites) is observed 2 hours after rectal administration of 1 supp. (With 400 mg tribenoside). Tribenoside is extensively metabolized in the liver. 20-27% of the administered dose is excreted in the urine as metabolites.
Indications for Procto-Glivenol ®
Hemorrhoids (internal and external).
Contraindications
hypersensitivity to drug components;
liver failure;
pregnancy (I trimester).
Application during pregnancy and lactation
Consideration should be given to the possible risk to the fetus or baby during pregnancy and breastfeeding.
Side effects
From the immune system: very rarely (<1/10000) — анафилактические реакции, включая ангионевротический отек, отек лица, бронхоспазм и сердечно-сосудистые нарушения.
On the part of the skin and subcutaneous tissues: rarely (\u003e 1/10000,<1/1000) — реакции в месте применения (жжение, сыпь, зуд и крапивница). Данные симптомы могут распространяться за пределы места применения.
Interaction
No interactions have been reported.
Method of administration and dosage
Rectally. With severe clinical symptoms, 1 supp is administered. in the morning and in the evening. With regression of acute symptoms - 1 supp. Once a day.
Overdose
Cases of drug overdose have not been registered.
Treatment: in case of accidental ingestion, gastrointestinal lavage is recommended, as well as symptomatic supportive therapy.
special instructions
Suppositories ProctoGlyvenol is a combined preparation with venotonic, local anesthetic and anti-inflammatory effects, used in the treatment of hemorrhoids.
The active ingredients are tribenoside and lidocaine.
Tribenoside improves vascular tone, reduces capillary permeability, antagonistically affects some endogenous substances that play the role of mediators in the development of pain and inflammation.
Lidocaine has a local anesthetic effect.
As a result, ProctoGlyvenol:
- in addition to symptomatic action, it is able to restore mucous membranes and blood vessels, which in the early stages of the disease contributes to complete recovery;
- improves the condition of hemorrhoidal veins, fights inflammation, edema, itching, restores microcirculation;
- local anesthetic action helps to temporarily relieve pain.
Composition of Procto-Glivenol (1 suppository):
- active substances: tribenoside - 400 mg; lidocaine - 40 mg;
- auxiliary components: witepsol E85 - 305 mg; witepsol W35 - 1255 mg.
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Price in pharmacies
Information on the price of Proctoglivenol ointment and suppositories in Russian pharmacies is taken from these online pharmacies and may differ slightly from the price in your region.
You can buy the drug in pharmacies in Moscow at the price: Procto-Glivenol suppositories (suppositories) rectal 10 pcs. - from 401 to 439 rubles.
Terms of dispensing from pharmacies - without a prescription.
Keep out of reach of children at temperatures up to 30 ° C. Keep out of the reach of children. The shelf life is 5 years.
The list of analogs is presented below.
What does Proctoglivenol ointment and suppositories help with?
The drug Proctoglivenol is prescribed for local and external use. As a rule, as part of a comprehensive treatment.
The drug causes a rapid relief of symptoms caused by hemorrhoids (pain, itching and skin tightness).
Suppositories Proctoglivenol are not prescribed for children. It is not recommended to take it during the first trimester of pregnancy or if you are allergic to any of the components of the product.
Instructions for use Proctoglivenol (suppositories / ointment), doses and rules
Suppositories are applied rectally. Before use, the suppository is released from the packaging and slightly moistened with water. The candle is gently inserted, lying on the right side, pressing the left leg to the chest.
The standard dosage of suppositories Proctoglivenol, according to the instructions for use - up to 2 pcs. per day in the acute period (morning and evening) and 1 suppository during the period of attenuation of hemorrhoid symptoms.
The duration of the course is determined by the attending physician.
Application of Proctoglivenol ointment
As in everything else, in acute cases, the ointment is used 2 times a day, with the symptoms of hemorrhoids fading once a day.
If necessary (hemorrhoids are located inside), you should use a special nozzle for applying the cream.
On average, one application takes about 1 gram of ointment. 1 tube is usually enough for 20-30 doses.
Important information
If during the use of the drug the symptoms of the disease do not diminish, or the development of unusual new sensations is noted, it is necessary to seek medical advice.
Application during pregnancy and lactation
Consideration should be given to the possible risk to the fetus or baby during pregnancy and breastfeeding.
In the 1st trimester of pregnancy, the use of the drug is contraindicated.
Application features
Before using the drug, read the sections of the instructions for use about contraindications, possible side effects and other important information.
Side effects of Proctoglivenol
The instructions for use warn of the possibility of developing side effects of the drug Proctoglivenol (suppositories / ointment):
- From the immune system: very rarely - anaphylactic reactions, including angioedema, facial edema, bronchospasm and cardiovascular disorders.
- From the skin and subcutaneous tissues: rarely - reactions at the site of application (burning, rash, itching and urticaria). These symptoms can spread beyond the site of application.
Contraindications
It is contraindicated to use Proctoglivenol for the following diseases or conditions:
- hypersensitivity to drug components;
- liver failure;
- pregnancy (I trimester).
Overdose
Cases of drug overdose are not registered and are not described in the instructions.
List of Proctoglivenol analogs
If it is necessary to replace the drug, two options are possible - the choice of another medication with the same active substance or a drug with a similar effect, but with a different active substance. Drugs with a similar effect are united by the coincidence of the ATX code.
Analogs Proctoglivenol, list of drugs:
- Pilex,
- Relief,
- Proctane,
- Anusol,
- Hemorrone,
- Bezornil,
- Aurobin.
When choosing a replacement, it is important to understand that the price, instructions for use and reviews for Proctoglivenol do not apply to analogues. Before replacing suppositories or ointments, you must obtain the approval of the attending physician and do not replace the drug yourself.
People who have used the drug leave positive reviews about Proctoglivenol candles, in a few days the drug relieves the unpleasant sensations of burning, itching and pain. Helps with cracks in the anus, with external and internal hemorrhoids, does not cause allergies.
Special information for healthcare providers
Interactions
Cases of interaction of suppositories and ProctoGlivenol cream with other drugs / substances have not been registered.
special instructions
If the existing symptoms of the disease do not decrease in the course of treatment or if new unusual sensations appear, you should consult a doctor.
When using the suppository, it is necessary to monitor the hygiene of the anal area, avoid excessive stress, take measures to maintain a soft stool consistency.
The drug does not affect the concentration of attention and the speed of mental and motor reactions when used in recommended doses.
Proctosedil (suppositories / ointment) - instructions for the drug, ...
Procto-glivenol is a combined antihemorrhoidal agent for topical use with venotonic, anti-inflammatory and local analgesic effects. The drug is original and manufactured by the Swiss pharmaceutical company Novartis.
Hemorrhoids is a very common disease: every third adult inhabitant of the planet Earth has the misfortune to be familiar with it. The peculiarities of the course of the disease predetermine the need to search for a drug with the best efficacy / safety ratio, while another important aspect that should in no case be neglected is the possibility of self-administration of the drug by the patient for a long time. All these conditions are fully met by the drug proctoglyvenol, intended for the treatment of internal and external hemorrhoids. The preparation contains two pharmacologically active components: tribenoside and lidocaine. Tribenoside (for those interested in pharmaceutical chemistry, we give the complete structure of its molecule - ethyl-3,5,6-tri-benzyl-O-glucofuranoside) is a venotonic agent. It normalizes venous tone, reduces venous congestion (congestion), reduces the permeability of the walls of small blood vessels and improves blood circulation in the capillary bed. In addition, tribenoside has an anti-inflammatory effect due to the local suppression of inflammatory mediators. Lidocaine, in turn, exhibits a local analgesic effect, which ensures rapid relief of the pain syndrome characteristic of hemorrhoids. It does not matter how much lidocaine was absorbed into the systemic circulation: the effect of this substance on the heart is in any case insignificant.
Procto-glivenol helps to alleviate the symptoms of hemorrhoids: pain, burning, itching, bleeding, skin tension, mucus secretion. It was experimentally found that the drug relieves pain syndrome and eliminates burning sensation in 100% of cases, relieves itching in 97% of cases. As a result of a clinical study, which involved 289 patients suffering from acute symptoms of hemorrhoids, proctoglyvenol suppositories showed an efficacy equal to prednisolone. Moreover, the first has an undeniable advantage, since its main active component practically does not enter the systemic circulation, therefore, it causes significantly fewer side effects. In addition, local glucocorticosteroid therapy always carries the risk of slowing down the healing process and scarring.
Proctoglyvenol comes in two dosage forms: rectal suppositories and rectal cream. Each of these dosage forms has its own benefits. So, suppositories provide deep penetration of the active components of the drug into the rectum, are securely packed, highly effective for internal hemorrhoids, they do not have to be stored in the refrigerator. Rectal cream is best used for external hemorrhoids. The tube of cream is equipped with a convenient nozzle. Subject to the recommended dosages of the drug, one tube is enough for 20-30 applications. The cream has a softening effect and goes well with procto-glivenol suppositories.
Pharmacology
Combined anti-hemorrhoidal drug.
Tribenoside reduces capillary permeability and improves vascular tone, antagonistically affects some endogenous substances that act as mediators in the development of inflammation and pain.
Lidocaine has a local anesthetic effect.
The drug causes a rapid relief of symptoms caused by hemorrhoids (pain, itching and skin tightness).
Pharmacokinetics
Suction
After applying the cream, 2-20% tribenoside is absorbed through the mucous membrane.
Metabolism
Tribenoside is rapidly metabolized in the liver.
Release form
Homogeneous rectal cream, white, with a weak characteristic odor.
Excipients: cetomacrogol 1000 - 4.44 g, cetyl alcohol - 5 g, isopropyl palmitate - 2 g, liquid paraffin - 10 g, methyl parahydroxybenzoate - 180 mg, propyl parahydroxybenzoate - 50 mg, sorbitan stearate - 1.56 mg, sorbitol acid - 6 g - stearic acid 9 g, water - 54.65 g.
30 g - aluminum tubes (1) complete with a polyethylene tip and a latex nozzle-cap - cardboard packs.
Dosage
The drug is prescribed rectally in the morning and in the evening until the expressed clinical symptoms disappear. With regression of acute symptoms, the frequency of use is reduced to 1 time / day.
For internal hemorrhoids, the cream is injected using a nozzle. 30 g of cream (1 tube) is enough for about 20-30 applications.
Overdose
Cases of drug overdose have not been registered.
Interaction
No interactions have been reported.
Side effects
From the immune system: very rarely (< 1/10 000) - анафилактические реакции, включая ангионевротический отек, отек лица, бронхоспазм и сердечно-сосудистые нарушения.
Skin and subcutaneous tissue disorders: rarely (\u003e 1/10 000,< 1/1 000) - кожные реакции в месте применения (жжение, сыпь, зуд и крапивница). Данные симптомы могут распространяться за пределы места применения.
Contraindicated in liver failure.
special instructions
If, while using the drug, the patient's condition does not improve significantly or unusual symptoms appear, the diagnosis should be verified.
During the period of treatment, the patient should monitor the hygiene of the anal area, avoid excessive stress, take measures to maintain a soft stool consistency.
Influence on the ability to drive vehicles and use mechanisms
Procto-Glivenol intended for local treatment of hemorrhoids. Procto-glivenolcontains two active components - tribenoside and lidocaine. The drug has anti-inflammatory, local anesthetic and venotonic effect. It helps to reduce pain, improve microcirculation and reduce the intensity of the inflammatory process. When using the drug, there is a decrease in vascular permeability, a decrease in venous stasis, elimination of such symptoms of hemorrhoids as itching and pain in the anus and rectum.
The mechanism of action of the drug and its therapeutic effects are due to the pharmacological properties of its active components.
Tribenoside is a synthetic drug of the glucofuranoside class. The mechanism of action of the drug is not fully understood, it is assumed that it is based on the ability of tribenoside to inhibit the activity of such endogenous amines as bradykinin, histamine and serotonin. In addition, tribenoside is an antagonist of some humoral factors that contribute to the development of vasodilation, edema, inflammation, and increased vascular permeability. In the course of research, it was noted that the drug does not affect the activity of endogenous vasoconstrictors, including norepinephrine and epinephrine. The drug helps to eliminate congestion in the veins, increases the tone of the veins and leads to a decrease in pathologically increased vascular permeability. As an antagonist of inflammatory mediators, tribenoside helps to reduce the intensity of the inflammatory process, has an analgesic and anti-edema effect. In addition, the drug reduces the adhesion capacity of platelets.
Lidocaine is a local anesthetic drug derived from acetanilide. The mechanism of action of the drug is based on the ability of lidocaine to block sodium channels, as a result of which the stabilization of cell membranes occurs. Lidocaine inhibits the generation and conduction of impulses in the nervous structures, while the suppressive effect of lidocaine on the conduction of both pain impulses and impulses of other modalities is noted. When applied topically, it has no effect on the myocardium.
When using the drug in the form of rectal suppositories, the bioavailability of tribenoside is 30% of that when using oral forms of tribenoside. The maximum plasma concentration of tribenoside for rectal administration is 1 μg / ml and is reached within 2 hours after the administration of the suppository. When using the drug Procto-glivenolin the form of a cream, about 2-20% of tribenoside enters the systemic circulation. Tribenoside is metabolized in the liver, excreted mainly by the kidneys in the form of metabolites.
Lidocaine is well absorbed when applied to mucous membranes, while after application to intact skin, the absorption of lidocaine is negligible. After rectal administration, the bioavailability of lidocaine is about 50%. Maximum plasma concentration of lidocaine after drug administration Procto-glivenol is about 0.7 μg / ml and is achieved within 2 hours. It is metabolized in the liver, excreted by the kidneys, both unchanged and in the form of metabolites.
Indications for use
A drug Procto-glivenol used as a means of conservative treatment of internal and external hemorrhoids in patients with mild and moderate severity of the disease.
In addition, the drug can be used to treat patients with severe hemorrhoids, if, for some reason, surgical treatment is impossible, including therapy for severe hemorrhoids that develop during pregnancy.
Mode of application
Procto-glivenol used rectally. It is recommended to wash your hands thoroughly before using the drug.
Adults with acute hemorrhoids are usually prescribed 1 suppository or 1 application of cream 2 times a day (morning and evening) until the acute symptoms disappear. After improvement of the clinical picture and the disappearance of pronounced clinical symptoms, they switch to the use of 1 suppository or 1 application 1 time per day.
Adults with internal hemorrhoids are usually prescribed a drug in the form of suppositories or a cream according to the standard scheme, while the cream is recommended to be injected into the rectum using a special applicator.
Side effects
Procto-glivenol usually well tolerated by patients, in isolated cases, when using the drug in the form of suppositories or a cream, patients experienced the development of local allergic reactions, including pruritus.
In isolated cases, when using the drug, patients had a burning sensation in the anal area.
Contraindications
- Increased individual sensitivity to drug components;
- the drug is not prescribed for women in the first trimester of pregnancy;
- due to the lack of reliable data on the effectiveness and safety of the drug Procto-glivenolin children, the drug is not recommended for use in pediatrics.
Pregnancy
A drug Procto-glivenol do not use during the first three months of pregnancy. In the second and third trimester, the drug Procto-glivenol can be prescribed by the attending physician if the expected benefit to the mother is higher than the potential risks to the fetus.
The drug can be used during lactation as directed by the attending physician.
Overdose
At the moment, there have been no reports of drug overdose.
If the drug was accidentally swallowed, gastric lavage and the intake of enterosorbents are indicated. If necessary, symptomatic therapy is performed.
