Content
With increased activity in the body of fungi of the genus Candida albicans, doctors recommend the drug Pimafucin (Pimafucin). The specified medication has three dosage forms, characterized by local action in the body. Self-medication is contraindicated.
Composition
The drug Pimufacin is a representative of the pharmacological group of antimycotics. A medication with fungicidal and antifungal properties is produced in the form of vaginal suppositories, tablets and cream. Features of each form of release:
- Round white tablets are enteric coated. The medicine is packaged in glass bottles of 20 pcs. Instructions for use are enclosed in a cardboard box.
- Candles of the "torpedo" shape of light yellow color are intended for intravaginal use. The preparation is packed into scripts made of aluminum foil, 3 pcs. The cardboard box contains 2-3 scripts and an annotation.
- Cream of light cream color with a specific odor is intended for local use (externally). The medicinal composition is poured into aluminum tubes, 30 g each.
Features of the chemical composition of Pimafucin depend on the form of release, described in detail in the instructions. The active ingredient is the same, called natamycin. The concentration in tablets, suppositories and cream is different:
|
Release form |
Active ingredient, g |
Excipients |
Shell composition |
|
tablets |
natamycin (0.1) |
povidone K30, lactose monohydrate, potato starch, magnesium stearate |
methyl parahydroxybenzoate, sucrose, titanium dioxide, gelatin, kaolin, talc, white beeswax, acacia gum, calcium carbonate, triacetin, cellacephate |
|
natamycin (0.2) |
decyloleate, cetyl ether wax, methyl parahydroxybenzoate, propylene glycol, purified water, cetostearyl alcohol, sodium lauryl sulfate, propyl parahydroxybenzoate. |
||
|
vaginal suppositories |
natamycin (0.1) |
solid fat, polysorbate 80, sodium bicarbonate, sorbitan trioleate, cetyl alcohol, adipic acid |
Pharmacodynamics and pharmacokinetics
Detailed instructions for the use of Pimufacin informs that natamycin, being a polyene (tetraene) antibiotic of the macrolide group, binds to the walls of the pathogenic fungus, violates their integrity, inhibits further growth and spread of pathogenic flora. Pimafucin is active against yeasts and molds. Positive dynamics is observed with activity:
- Candida;
- Aspergillus;
- Cephalosporium;
- Fusarium;
- Penicillium.
When using this medication with respect to Pseudoallescheria boydii and dermatophytes, a mediocre therapeutic effect is observed, therefore it is better to immediately select an analogue. Pimafucin is absorbed in the lumen of the large intestine, the active substance in relatively small doses enters the bloodstream. With the local area of \u200b\u200bapplication of the drug, a mediocre effect on the focus of pathology is observed.
Indications for use
- cream: dermatomycosis, diaper rash, vulvovaginitis, vulvitis, vaginitis, otitis media, candidiasis of the nail plates and skin;
- tablets: candidiasis of the intestinal mucosa, long-term antibiotic therapy, taking cytostatics, corticosteroids, acute atrophic candidiasis, acute pseudomembranous candidiasis with cachexia;
- vaginal suppositories: thrush, vulvovaginal candidiasis, vulvovaginitis, vulvitis, balanoposthitis.
Method of administration and dosage
The medicine Pimafucin effectively destroys pathogenic fungi of different localization in the body. The recommended daily doses and method of administration of the drug depend on the form of release and the nature of the pathological process. Before starting the course, you need to individually consult with your doctor.
Candles Pimafucin
The drug Pimafucin for thrush is more often recommended in the form of vaginal suppositories. The patient is required to inject 1 suppository through the vagina for 5-7 days without interruption. In a complicated clinical case, the course of treatment is extended to 2-3 weeks. It is advisable to carry out a home procedure before going to bed, or after the introduction of the suppository, remain in a horizontal position for some time. Otherwise, the therapeutic compound flows out and the desired therapeutic effect is weakened. Candles are not prescribed for men.
Cream
This form of release of Pimafucin is equally suitable for women and men in the complex treatment of balanoposthitis, vulvovaginitis and vulvitis. The drug is intended for external use. According to the instructions, it is required to apply the medicinal composition to the foci of pathology (skin, nails, genitals) up to 3-4 times a day. The course of treatment depends on the stage of the pathological process and is negotiated individually.
Pimafucin tablets
With progressive intestinal candidiasis, doctors recommend taking Pimafucin tablets for a weekly course. During this time, an adult patient takes 4 tablets, a child - 2 tablets. per day. The recommended dose of the medicine must be swallowed whole, washed down with water. Do not pre-chew or dissolve in the mouth.
Pimafucin for men
With an exacerbation of candidiasis, doctors prescribe local application of Pimafucin cream to men. In complicated clinical cases, an integrated approach to the health problem is recommended. Topical application of the cream is complemented by oral administration of tablets. The daily doses and the course of treatment with Pimafucin depend on the disease, and are negotiated individually with a specialist.
special instructions
Treatment of thrush with Pimafucin takes a full course, even if positive changes in well-being are noticeable after 2-3 days. If drug therapy is stopped prematurely, the disease progresses again. The instructions for use contain instructions for patients:
- Pimafucin is prescribed with caution for glucose-galactose malabsorption, lactase deficiency.
- Pills are not prescribed for infants, since there are difficulties with their oral administration.
- The drug does not inhibit the functions of the nervous system, therefore, during treatment, it is allowed to drive a vehicle, engage in intellectual activity.
During pregnancy
The medicine Pimafucin is recommended for use by pregnant women. Treatment proceeds under medical supervision with individual correction of the prescribed daily dosages. For chronic infections, oral pills are often supplemented with topical vaginal suppositories. The course of treatment lasts from 7 to 10 days. During lactation, such a pharmaceutical appointment is also not prohibited. Doctors recommend temporarily stopping breastfeeding, transferring the child to adapted formulas.
Pimafucin for children
With candidiasis of the gastrointestinal tract, doctors do not prohibit the use of Pimafucin in childhood. According to the instructions for use, the recommended dosage is 1 table. morning and evening. In complicated clinical cases, the permissible dose is increased to 4 pcs. Additional use of suppositories and Pimafucin cream is discussed with the pediatrician.
Drug interactions
Tablets, cream and suppositories for thrush Pimafucin are recommended for the patient as part of a complex treatment for the extermination of the pathogenic flora of the fungal nature. In the detailed instructions for use, information on drug interactions with representatives of other pharmacological groups is not provided. Doctors warn patients against self-medication.
Side effects
Pimafucin is well tolerated by the affected organism. Side effects are extremely rare, presented in the instructions for use of the drug:
- digestive tract: nausea, vomiting, diarrhea;
- allergic reactions: skin rash, urticaria, swelling and hyperemia of the epidermis;
- local reactions when using suppositories and cream.
Contraindications
The drug Pimafucin is approved for use by not all patients. According to the instructions, the list of medical contraindications is limited by the increased sensitivity of the body to the active substances of the specified antifungal agent. Age restrictions must be individually coordinated with a dermatologist, district pediatrician.
Terms of sale and storage
Pimafucin is sold in a pharmacy, released without a prescription. According to the instructions for use, it is required to store the medication in a dry and cool place, away from sunlight, inaccessible to small children. The shelf life of Pimafucin is 24 months.
Analogs
If Pimafucin does not help destroy the pathogenic flora, doctors recommend replacing the antifungal drug. Reliable medicines with antimycotic and fungicidal action, their brief description:
- Alpha Normix. These are round orange tablets with a chemical composition of rifaximin. According to the instructions, the patient is prescribed 1 table. every 8 hours. The course of treatment is no longer than 7 days, the doses are adjusted individually.
- Nystatin-Health. Antifungal agent in the form of film-coated tablets with nystatin in the chemical composition. According to the instructions, appoint 1-2 tables. per day for 1-2 weeks without interruption.
- Nystatin. These are vaginal suppositories, ointments and capsules with the same active ingredient. According to the instructions, these forms of release are allowed to be combined in one treatment regimen to enhance the therapeutic effect.
- Livarol. These are vaginal suppositories, recommended for thrush, with ketoconazole in a chemical composition. According to the instructions for use, the medicine is allowed during pregnancy and lactation. The patient is prescribed 1-2 soup. per day.
- Terzhinan. It is an expensive antifungal drug in the form of vaginal suppositories. According to the instructions, the patient is prescribed 1 suppository before bedtime. It is recommended not to get out of bed after the dose has been administered.
- Clotrimazole. This medication has five forms of release - gel, cream, ointment, solution, tablets, vaginal suppositories. Contains the component of the same name in different concentrations. Daily doses and course of treatment are described in the instructions for use.
Pimafucin price
The cost of the specified medication varies from 450 to 600 rubles. Online purchases are cheaper for the patient. The retail price depends on the form of release of the drug, the complete set of each package, the rating of the capital's pharmacy.
Video
Content
For the treatment of intestinal candidiasis in pregnant women, men or children, a gynecologist may prescribe Pimafucin tablets. They have a complex effect, are safe for use even in newborns, because the active substance natamycin in the composition is not absorbed by the blood. Check out the indications for the use of Pimafucin, dosage and contraindications.
Pimafucin tablets - instructions for use
The antifungal drug Pimafucin in tablets is produced for the treatment of intestinal candidiasis, internal mycoses and other fungal diseases. According to the pharmacological classification, the drug belongs to the group of natamycin antibiotics, which selectively act on pathogenic pathogens. The active ingredient in the medication is natamycin.
Composition
One tablet of an effective antifungal antibiotic contains 100 mg of natamycin. The full composition of Pimafucin is indicated in the table below:
Other forms of the drug contain:
- Suppositories - 100 mg of natamycin, excipients cetyl alcohol, solid fat, sorbitol, polysorbate, sodium bicarbonate, adipic acid.
- 1 g of cream accounts for 20 mg of natamycin, additional components are decyloleate, wax based on cetyl esters, cetostearyl alcohol, sodium lauryl sulfate, methyl parahydroxybenzoate, propyl parahydroxybenzoate, propylene glycol, purified water.
Release form
Pimafucin is available in white or off-white enteric coated round tablets. The medicine is enclosed in 20 pieces in dark glass vials and cardboard boxes. Other formats of Pimafucin are vaginal suppositories (3 and 6 pieces in a blister strip made of PVC or aluminum), cream for external use (plastic or metal tube 30 g), suspension for the treatment of the oral cavity and ear canal (2.5%).
Pharmacodynamics and pharmacokinetics
The active substance of Pimafucin natamycin is included in the group of polyene antimycotics from the group of macrolide antibiotics, has a wide spectrum of action. Suppresses candida fungi, dermatophytes and other pathogenic microorganisms are considered less susceptible. The instructions for use emphasize that natamycin is active against all fungi, but doctors prefer to treat them only with candidiasis.
Natamycin has fungicidal activity, blocks special components (sterols) of the cell membranes of pathogens, which leads to their death. In clinical practice, no cases of resistance (resistance) to the active substance have been observed. It is practically not absorbed in the alimentary canal, is not absorbed from the mucous membranes and skin. Due to the enteric coating of Pimafucin tablets, their action occurs inside the intestine.
Indications for use
According to the instructions for use of the drug, the following indications for its use are distinguished:
- intestinal candidiasis;
- treatment of dermatomycosis, skin lesions;
- elimination of symptoms of thrush;
- acute pseudomembranous and acute atrophic candidiasis;
- treatment of patients with cachexia, immune deficiency, treated with antibiotics, corticosteroids, cytostatics;
- sanitation of the intestinal reservoir with candidiasis of the skin, mucous membranes, with advanced or chronic vaginal candidiasis, vulvitis, vulvovaginitis, balanoposthitis with increased secretions;
- complex treatment of systemic skin diseases;
- fungal infections of the genitals, skin, appendages of the skin, candidiasis of the nails.
How to take Pimafucin
Pills are taken orally, regardless of food intake, since it does not affect its effectiveness of antifungal components. Pimafucin dosage:
- with intestinal damage, adults take 100 mg of natamycin (1 tablet) four times a day, children - twice, the course of treatment is a week;
- with a persistent course of vaginitis caused by fungi of the genus Candida, together with local antifungal drugs (Pimafucin suppositories), to sanitize the focus of infection inside the intestine, you need to drink tablets 4 times a day, for a course of 10-20 days;
- in the treatment of thrush and its varieties on the genitals, the duration of treatment lasts up to three weeks (a break for menstruation is done only when using suppositories), together with a sexual partner;
- with candidiasis of the nails, together with the cream, tablets are used four times a day for a course of 2-3 months;
- with widespread candidomycosis of the skin, together with topical application of the cream, 4 tablets are drunk per day for a weekly course;
- with onychomycosis, together with the use of natamycin and cream, 4 tablets are taken per day for a course of 2-3 months;
- the duration of therapy for a fungal infection is set individually, after the symptoms disappear, treatment continues for several more days.
special instructions
The instructions for use of the medicinal product contain a section of special instructions. Small excerpts from it:
- the medication contains 66 mg of lactose monohydrate (milk sugar) and 122 mg of sucrose - patients with rare congenital intolerance to galactose, fructose, lactase deficiency, glucose-galactose malabsorption or sucrose-isomalt deficiency should consult with their doctor before taking;
- tablets are not recommended for use in infants due to difficulty in swallowing;
- the drug does not affect the speed of psychomotor reactions, therefore it can be used when driving cars and dangerous mechanisms.
During pregnancy
Pimafucin is not prohibited from use during pregnancy. It is included in the complex treatment of thrush, which occurs due to changes in the hormonal background when carrying a child, which occurs in conjunction with a decrease in immunity and a violation of the normal bacterial flora. In case of chronic infection or advanced disease, a cream is additionally prescribed to the pills, contraception to protect the partner's organs is assumed to be barrier means.
Pimafucin during lactation
If thrush has affected the mammary glands of a nursing mother, gynecologists may prescribe Pimafucin tablets to her. They eliminate burning, painful sensations, tingling sensations in the nipple area. Also, the drug treats candidiasis of the oral mucosa, mycosis of the ear canal. For the duration of treatment, it is worth refusing to feed, because the medicine can worsen the quality of milk.
Pimafucin for children
The peculiarities of the drug is the lack of penetration into the gastrointestinal tract, which makes it attractive compared to other antibiotics for children. Pimafucin does not cause a large number of adverse reactions, it is prescribed for candidiasis of the gastrointestinal tract. Children's dosage is 100 mg (one tablet) twice a day. Older children can be prescribed up to four pieces, up to a year - part of the pill. Complex therapy with candles or cream is allowed.
Drug interactions
Instructions for use Pimafucin in the form of tablets indicates that drug interaction of the drug with other medicines has not been detected. This means that you can safely combine funds, but only after consulting a doctor. It is allowed to take several varieties of Pimafucin in parallel to speed up recovery and reduce the time for therapy.
Contraindications
The drug Pimafucin in tablet form has few contraindications, because it is considered one of the safest antimycotics and antibiotics. The only warning for patients is hypersensitivity to natamycin or other derivatives of the drug. It is worth consulting with your doctor about taking medication for patients with diabetes mellitus, possible allergies.
Side effects and overdose
In the first days of taking an antibiotic, side effects may occur that go away on their own with the course of treatment. These include nausea, vomiting, diarrhea, and itching. If the signs become more pronounced or other adverse reactions join them, you should consult a doctor. According to the instructions, an overdose of the drug is unlikely due to its low absorption. Her cases are unknown to practice.
Terms of sale and storage
The drug is dispensed from pharmacies without a prescription. Stored in a place protected from light and children at temperatures up to 25 degrees. The shelf life is four years.
Analogs
The tablet format of the drug is used only for the treatment and prevention of candidiasis, but they cannot treat thrush (vaginal and other). For the latter, candles and cream are used. There are no complete analogues of Pimafucin, but there are approximate substitutes for the treatment of gastrointestinal candidiasis, which have a systemic effect - they enter the bloodstream, act on all systems and organs of the body, have some toxicity to the liver and side effects, according to reviews:
- Irunin;
- Itraconazole;
- Mycozoral;
- Mycosist;
- Nystatin;
- Terbinafine;
- Fluconazole.
Pimafucin price
You can buy Pimafucin on the Internet or in the usual pharmacy departments. The price depends on the level of pricing of trade enterprises and the form of release. The approximate cost of Pimafucin in different formats is indicated below.
Candidiasis is a common ailment of the reproductive system, characterized by the development of inflammation, the appearance of itching and burning in the perineal region, and curdled vaginal discharge. However, candidiasis can affect not only the external genital organs, but also the oral cavity and intestines. The disease can develop in both women and men and children.
The causative agent of the disease is yeast-like fungi of the genus Candida. These organisms are opportunistic. They inhabit the vagina, mouth and intestines. Direct infection is not always the impetus for the onset of the disease. For symptoms of this unpleasant disease to appear, sometimes it is enough to reduce immunity, a stressful situation, and take antibacterial drugs that provoke an imbalance in the vaginal environment. The frequency of exacerbations of urogenital candidiasis is due to the growth of microflora not only in the mucous membranes of the reproductive system, but also in the gastrointestinal tract. In this regard, the treatment of fungal infection should be carried out together with the seeding of the intestine with bifidobacteria and lactobacilli.
Treatment of thrush should be timely and appropriate. One of the most effective antifungal drugs is Pimafucin for thrush. The medicine is a broad-spectrum antibiotic. This drug is safe and easily tolerated by patients. In addition, it does not have a detrimental effect on other organs and systems, because it works exclusively at the site of the lesion and does not penetrate the bloodstream.
The selection of a drug, in particular Pimafucin, for signs of thrush can only be dealt with by a qualified doctor, and only after a thorough examination. Self-medication is strongly discouraged. It can hurt you.
Pimafucin is an antifungal agent. The active ingredient of the drug is natamycin, which is a polyene antibiotic. The antifungal effect of Pimafucin from thrush is due to the ability to suppress the metabolic processes of cells of fungal microflora. The medicine, due to the fact that it is produced in several forms, helps to get rid of pathoorganisms of various locations in gynecological, dermatological and obstetric practice.
- fungal infections of the dermis and mucous membranes;
- thrush of the genitals;
- lesions of the middle ear;
- intestinal and nail candidiasis;
- vulvitis, vaginitis, trichomoniasis;
- dermatomycosis.
An effective remedy for the reproduction of yeast fungi due to the intake of antibacterial drugs, cytostatics and corticosteroids. In addition, the drug is prescribed for complex therapy in case of systemic fungal pathology.
Pimafucin-drug for thrush is produced in the form of suppositories, cream, tablets. The active ingredient of the drug is natamycin. Additional substances differ depending on the form of release of the drug.
Candles. The package contains 3-6 cylindrical candles, rounded on one side. Candles can have a whitish, yellowish or slightly brown tint. One candle contains one hundred milligrams of the active ingredient.
In addition to natamycin, the drug is rich in additional components:
- cetyl alcohol;
- sodium bicarbonate;
- adipic acid;
- solid fats;
- sorbitan;
- trioleate;
- polysorbate 80.
Tablets. The package contains twenty tablets of a round shape, white color in blisters. Each tablet contains 100 mg of active ingredient.
The drug is rich in the following additional components:
- potato starch;
- talcum powder;
- lactose;
- beeswax;
- titanium dioxide;
- kaolin;
- gelatin;
- sucrose.
Cream.One gram of the drug accounts for 20 mg of the active ingredient. The preparation contains a small amount of organic alcohols, sodium lauryl sulfate, decyloleate, purified water. It is very rare to find a drug in the form of a topical suspension.
Bottle - 20 ml. One milliliter of the drug accounts for 25 milligrams of the active ingredient. The liquid form is indicated for use in oral candidiasis in newborns, people of the older age category, as well as in patients after severe pathologies of infectious diseases.
The main side effects of Pimafucin include: nausea, diarrhea, impaired functioning of the gastrointestinal tract, burning, dryness, rashes on the dermis. Do not self-medicate and use ointments or creams, tablets or suppositories without the knowledge of the doctor.
Only a specialist can select the form and dosage of the medicine. The answer to the frequently asked question: "How much does Pimafucin cost from thrush in the pharmacy?" - it all depends on the form of the drug, the price policy of the pharmacy, the manufacturer, as well as the duration of the therapeutic course. The biggest drawback of the drug is its cost. This is especially felt in the treatment of the chronic form, when the course lasts a month or more, and requires complex treatment: the use of both suppositories and tablets. But you don't think much about the price of the drug, when exacerbations of the disease lead the patient to nervous exhaustion in view of discomfort, pain sensations that disrupt the usual rhythm and way of life.
The cost of tablets is from 300 to 800 rubles, cream - from 150 - 400 rubles, suppositories - from 160 - 700 rubles. Experts and patients note a long and quick effect in the treatment of thrush with Pimafucin. This is due to the fungicidal properties of the drug. During pregnancy and lactation, this medication is indispensable, because it does not have a toxic effect on the development of the fetus or newborn. In addition, the remedy has proven itself well for the treatment of chronic candidiasis, thrush of the oral cavity and intestines.
Negative reviews of the drug for candidiasis are primarily associated with a violation of medical prescriptions, as well as with the interruption of the course of therapy. Thrush is a real disaster of our time. It is almost impossible to get rid of pathology using only medicines. It is equally important to follow the rules: to give up eating sweets, from wearing synthetic underwear, from having sexual intercourse during therapy, and to observe hygiene.
Pimafucin: instructions for using a tablet for thrush
The use of tablets is prescribed for:
- fungal infections of the mucous membranes and skin;
- otomycosis, otitis externa;
- thrush of the dermis and nails;
- intestinal candidiasis;
- vaginitis, vulvitis, vulvovaginitis, provoked by fungi of the genus Candida;
- dermatomycosis.
Intestinal candidiasis is characterized by the appearance of malaise, soreness in the epigastric region, nausea, vomiting, diarrhea, colic, and loss of appetite. The reproduction of pathogenic microflora causes disruption of the functioning of the gastrointestinal tract, vitamin deficiency, disorders of the central nervous system, allergies, and inflammation in the oral cavity. Due to intestinal damage, the appearance of foci of infection in the genitourinary system and kidneys is noted.
So, for example, chronic vaginal candidiasis can be triggered by the yeast flora that populates the gastrointestinal tract. On the other hand, genital thrush often provokes the reproduction of pathogenic flora in the intestines. An effective and proven remedy - Pimafucin in the form of tablets will help to get out of this circle.
Take Pimafucin tablets for thrush, according to the instructions for use, it is necessary in parallel with suppositories. Each tablet of the drug is coated, due to which the active ingredient is delivered directly to the site of infection. Moreover, the drug acts exclusively on mucous membranes and skin.
According to the instructions for the use of tablets, Pimafucin for thrush can be used by both men, women and children. In addition, the remedy can be used even during pregnancy. The drug is harmless, does not have a detrimental effect on the fetus - that is why it is approved for use at any stage of pregnancy.
Pimafucin (instructions for use): tablets for thrush:
- For the treatment of intestinal candidiasis, adults are prescribed 1 tablet four times a day, children - a tablet twice a day. The duration of the therapeutic course is a week.
- For the treatment of fungal nail infections, a tablet is prescribed four times a day. The treatment course is 60 days. In parallel, the application of the cream is prescribed.
- For the treatment of vulvovaginal candidiasis, it is recommended to take one tablet four times a day along with the use of suppositories. The duration of therapy is three weeks.
- Treatment of widespread candidiasis of the skin consists in taking one tablet four times a day, as well as applying a cream. The duration of the course is a week.
Suppositories from thrush Pimafucin drug analogues
Suppositories are prescribed for the treatment of vaginitis, vulvitis, vulvovaginitis, provoked by yeast fungi of the genus Candida. Only a qualified gynecologist can prescribe the use of suppositories for thrush called "Pimafucin". It is necessary to use candles once a day, before bedtime. The drug is administered in the supine position. The duration of the course of therapy is a week. After the disappearance of symptoms, it is recommended to extend the treatment for several days.
It is not worthwhile to carry out therapy with menstruation, that is, to use suppositories from the thrush Pimafucin, because the agent can be washed out through the blood. If the symptoms of the pathology have spread to the mucous membranes of the external genital organs, the use of a cream is prescribed as an additional therapy. With the low effectiveness of suppositories from the thrush Pimafucin, pills are prescribed - one to four times a day. The course of therapy is three weeks. Men are prescribed the use of a cream.
The duration of the course, dosage, treatment regimen can only be selected by a doctor. Of course, suppositories for thrush Pimafucin are effective and effective. But they will only help if it is used appropriately. Analogs of the Pimafucin tablet form: Nystatin-Health - 60 rubles, Alpha Normix - 900 rubles. Analogs of suppositories: Clotrimazole - 60 rubles, Livarol - 360 rubles, Nystatin - 90 rubles.
Antifungal polyene antibiotic of the macrolide group with a wide spectrum of action.
Drug: PIMAFUCIN®
The active substance of the drug:
natamycin
ATX encoding: D01AA02
KFG: Antifungal drug for external use
Registration number: P No. 013552 / 02-2002
Date of registration: 09.01.07
Owner reg. ID: YAMANOUCHI EUROPE B.V. (Netherlands)
Pimafucin release form, drug packaging and composition.
Enteric-coated tablets are white, round.
1 tab.
natamycin
100 mg
Excipients: potato starch, polyvinylpyrrolidone, magnesium stearate, lactose, gelatin, acacia (gum arabic), methyl paraoxybenzoate, calcium carbonate, kaolin, talc, cellulose acetate phthalate, triacetin, white beeswax, titanium oxide, sucrose.
20 pcs. - bottles (1) - cardboard packs.
Cream for external use 2% homogeneous, light shade.
1 g
natamycin
20 mg
Excipients: cetiol V, wax based on cetyl ethers, cetostearyl alcohol, sodium lauryl sulfate, methyl paraoxybenzoate, propylene glycol, purified water.
30 g - tubes (1) - cardboard packs.
Torpedo-shaped vaginal suppositories, from white to pale yellow.
1 supp.
natamycin
100 mg
Excipients: cetyl alcohol, solid fat, sorbitol triolite, polysorbate 80, sodium hydrogen carbonate, adipic acid.
3 pcs. - blisters (1) - cardboard packs.
The description of the product is based on the officially approved instructions for use.
Pharmacological action Pimafucin
Antifungal polyene antibiotic of the macrolide group with a wide spectrum of action. Has a fungicidal effect. Natamycin binds sterols of cell membranes, disrupting their integrity and function, which leads to the death of microorganisms. Most pathogenic yeasts, especially Candida albicans, are sensitive to natamycin.
Dermatophytes are less sensitive to natamycin.
Resistance to natamycin does not occur in clinical practice.
Pharmacokinetics of the drug.
When taken orally, natamycin is practically not absorbed from the gastrointestinal tract. When applied to intact skin and mucous membranes, it practically does not undergo systemic absorption.
Indications for use:
For pills
Treatment and prevention of non-invasive intestinal candidiasis (including after taking antibiotics, cytostatics, corticosteroids).
For cream
Infections of the skin and mucous membranes caused by Candida or other sensitive yeast, yeast-like fungi or dermatophytes (including balanoposthitis, otomycosis).
For vaginal suppositories
Vulvovaginal candidiasis.
Dosage and method of administration of the drug.
With intestinal candidiasis, adults are prescribed 100 mg (1 tab.) 4 times / day for an average of 1 week. Children are prescribed 100 mg (1 tab.) 2 times / day.
For dermatomycosis (including candidiasis of the skin, diaper rash in children), the cream is applied to the affected surface of the skin one or several times a day.
With otomycosis, the affected surface is smeared with cream one or more times a day. Before using the drug, the ear is cleaned. After applying the drug, a tampon made of natural material (cotton, wool) is placed in the ear canal.
For vaginitis, vulvitis, vulvovaginitis, 100 mg (1 vaginal suppository) is prescribed for 3-6 days. The suppository is inserted into the vagina in the supine position, as deep as possible, 1 time / day at night. In case of persistent vaginitis caused by Candida albicans, the drug is additionally prescribed inside (1 tab. 4 times / day for 10-20 days) to sanitize the focus of candidal infection in the intestine. For the treatment of candidal lesions of the partner's genitals, Pimafucin is used in the form of a cream.
With balanoposthitis, the cream is applied to the affected skin one or more times a day.
The duration of the course of treatment is set individually. After the disappearance of the symptoms of the disease, it is recommended to continue treatment for several more days.
Side effect of Pimafucin:
From the side of the digestive system: nausea, diarrhea are possible (occurring in the first days of taking the drug in the form of tablets and passing independently during treatment).
Local reactions: possible slight irritation, burning sensation (when using cream, vaginal suppositories).
Contraindications to the drug:
Hypersensitivity to the drug.
Application during pregnancy and lactation.
It is possible to use Pimafucin during pregnancy and lactation.
Special instructions for the use of Pimafucin.
Vaginal suppositories under the influence of body temperature quickly dissolve, forming a foamy mass, which contributes to the uniform distribution of the active substance.
In the case of a chronic or recurrent infection, topical treatment can be supplemented with pills and a cream.
Cetyl alcohol, which is part of vaginal suppositories, can cause hypersensitivity reactions.
During menstruation, suppository therapy is interrupted.
During the period of use of suppositories, there is no need to exclude sexual intercourse. However, it is recommended to conduct an examination of the sexual partners and, if a candidal lesion is detected, to conduct a course of treatment with Pimafucin. Also, during the period of treatment, barrier contraception should be used.
Use in pediatrics
Pimafucin can be given to newborns.
Drug overdose:
At present, no cases of overdose of the drug Pimafucin have been reported.
Interaction of Pimafucin with other drugs.
The drug interaction of the drug Pimafucin is not described.
Conditions of sale in pharmacies.
The drug is available by prescription.
Terms of storage conditions of the drug Pimafucin.
The drug should be stored out of the reach of children at a temperature of 15 ° to 25 ° C. The shelf life of suppositories is 2 years. The shelf life of tablets and cream is 4 years.
vaginal suppositories; enteric-coated tablets; cream.Composition:
Vaginal suppositories. 1 suppository contains: natamycin 100 mg.Enteric-coated tablets. 1 tablet contains: natamycin 100 mg.
Cream. 1 g of cream contains: natamycin 20 mg.
Description:
Vaginal suppositories: torpedo-shaped, color from white to pale yellow;
Enteric-coated tablets: White round film-coated tablets.
Cream: homogeneous cream of light shade.
Pharmacological properties
Pharmacodynamics.Antifungal polyene antibiotic from the macrolide group with a wide spectrum of action. Has a fungicidal effect. Natamycin binds sterols of cell membranes, disrupting their integrity and function, which leads to the death of microorganisms. Most pathogenic yeasts are sensitive to natamycin, especially Candida albicans.Dermatophytes are less sensitive to natamycin. Resistance to natamycin does not occur in clinical practice. Natamycin in tablets, due to the enteric coating, acts only in the intestine.
Pharmacokinetics.Natamycin is not absorbed from the gastrointestinal tract, through intact skin and mucous membranes.
Indications for use
fungal diseases of the skin and mucous membranes caused by pathogens sensitive to the drug, including:
- acute pseudomembranous and acute atrophic candidiasis in patients with cachexia, immune deficiency, as well as after therapy with antibiotics, corticosteroids, cytostatics;
- otomycosis, otitis externa, either primarily caused by fungi, or complicated by candidiasis;
- candidiasis of the skin and nails;
- intestinal candidiasis;
- vaginitis, vulvitis, vulvovaginitis, balanoposthitis, caused mainly by fungi Candida;
- dermatomycosis.
Contraindications.
Hypersensitivity to drug components.
Method of administration and dosage.
With intestinal candidiasis, adults are prescribed 1 tab. 4 times / day on average within 1 week. Children are prescribed 1 tab. 2 times / day
With dermatomycosis (including candidiasis of the skin and nails, diaper rash in children)the cream is applied to the affected surface of the skin and nails 1 or more times a day.
With otomycosisthe affected surface is smeared with cream 1 or several times a day. Before using the drug, the ear is cleaned. After applying the drug, a turunda made of natural material (cotton, wool) is placed in the ear canal.
With vaginitis, vulvitis, vulvovaginitisappoint 1 vaginal suppository for 3-6 days. The suppository is inserted into the vagina in the supine position, as deep as possible, 1 time / day. at night. With a persistent course of vaginitis caused Candida albicans,additionally, tablets are prescribed inside (1 tab. 4 times / day for 10-20 days) to sanitize the focus of candidal infection in the intestine. For the treatment of candidal lesions of the partner's genitals, Pimafucin® is used in the form of a cream.
With balanoposthitisthe cream is applied to the affected skin one or more times a day. The duration of the course of treatment is set individually. After the disappearance of the symptoms of the disease, it is recommended to continue treatment for several more days.
Interaction with other medicinal products
The drug interaction of the drug Pimafucin is not described.
Special instructions.Vaginal suppositories under the influence of body temperature quickly dissolve, forming a foamy mass, which contributes to the uniform distribution of the active substance. In the case of a chronic or recurrent infection, topical treatment can be supplemented with pills and a cream. Ethanol, which is part of vaginal suppositories, can cause hypersensitivity reactions. During menstruation, suppository therapy is interrupted. During the period of treatment with suppositories, there is no need to exclude sexual intercourse. However, it is recommended to conduct an examination of the sexual partners and, if a candidal lesion is detected, to conduct a course of treatment with Pimafucin. You should also provide for the use of barrier contraceptives during the treatment period.
Pimafucin® can be administered to newborns.
Pregnancy and lactation.It is possible to use Pimafucin during pregnancy and lactation.
Side effect.
From the digestive tract:possible nausea and diarrhea (arising in the first days of taking the pills and passing on their own during treatment). Local reactions:possible slight irritation, burning sensation (when applying cream, vaginal suppositories).
Overdose of the drug.Currently, no cases of overdose of Pimafucin® have been reported.
Storage conditions.The drug should be stored at a temperature of 15 to 25 ° C out of the reach of children.
Shelf life.The shelf life of tablets and cream is 4 years. The shelf life of vaginal suppositories is 2 years. Do not use after the expiration date.
