Omnik Okas, whose instructions for use contain detailed information about the drug, is successfully used to treat disorders of urination processes in prostate adenoma. Refers to alpha-1-blockers. The practice of using such a remedy shows that their treatment is better than with the help of similar drugs. Let's consider the main aspects of its action, indications, contraindications, side effects and conditions of admission.
Drug action
The active substance of this drug is white crystals, poorly soluble in water, alcohols, and concentrated acetic acid. Alpha-1-blockers are used to block postsynaptic smooth muscle adrenergic receptors. Omnik (Tamsulosin) also has such an effect. A means with a fixed release of the active ingredient leads to a decrease in the tone of the smooth muscles of the bladder neck, as well as the area of \u200b\u200bthe urethra passing through the prostate. This greatly facilitates the flow of urine.
Simultaneously with this action, the capsules relieve signs of obstruction and irritation of the bladder. But similar phenomena are observed very often with benign prostatic hyperplasia in men. The pronounced effect of taking the pills is noted already 14 days after the start of the intake.
Capsules have little effect on blood pressure when used at a standard dosage. The main active component of the drug is tamsulosin. The introduction of the drug does not lead to an increase in the incidence of tumors. Taking large dosages of the drug helps to reduce fertility.
This medication, thanks to a special dosage form, has a so-called controlled release. This means that the active ingredient, tamsulosin, enters the bloodstream gradually. The exposure of the drug is constant, its changes during the day are not very pronounced. 
The absorption process takes place in the intestines. Its indicator is 57% of the dose. Food intake does not affect this value. After consumption, the highest concentration in the blood is observed after 6 hours. On the fourth day of treatment, it is possible to achieve an equilibrium content of the active component of the drug, which provides a good result. Since the release of the active substance is prolonged, the deviations between its maximum and minimum concentration differ slightly - from 6 to 11 ng per 1 ml.
The drug binds to proteins by 99%, is metabolized in the liver. Decay products are removed in the urine. A very small part of the substance leaves the body unchanged and through the kidneys. With a single dose, the half-life (in the case of a standard dosage) is 19 hours, and relative to the equilibrium concentration, 15 hours.
Indications and contraindications for admission
Omnic is mainly indicated for the treatment of urinary disorders associated with benign prostate adenoma. Contraindications for admission are as follows:
- hypersensitivity to the active ingredient;
- terminal stages of liver failure;
- chronic kidney failure (with creatinine clearance lower than 10 ml / min).
Omnik Onik is used only orally. The dosage prescribed by the doctor must be followed. The product is best taken with plenty of water. Taking medication does not depend on the time of day and food intake. Reception possible during breakfast, lunch or dinner. The tablet must be swallowed completely, avoiding chewing (in this case, there will be no prolonged action of the drug, and it will not be able to achieve the required therapeutic effect).
To obtain the best result, it is necessary not to change the frequency of admission and dosage indicated by the doctor, do not stop taking it without permission. All this will affect the risk of occurrence 
side effects.
Patients with severe urination disorders as a result of benign prostatic hyperplasia must remember that the course of treatment with such a remedy is quite long. The period of using the medication can only be determined by the doctor, and there is no standard prescription here. Long-term use of the medication is not addictive.
Side effects and overdose
Among the side effects of this remedy are the following:
- Dizziness, sometimes severe headache.
- Fainting.
- Sleep disorders (in the form of insomnia).
- Increased heart rate.
- Increased blood pressure with pain in the chest area.
- Inflammation of the nasal mucosa.
- Disorders of the digestive system in the form of constipation or diarrhea.
- Allergic reactions in the form of a rash, sometimes - urticaria and very rarely - Quincke's edema.
- Ejaculation disorder (retrograde semen movement). Pain in the penis (priapism symptoms).
- Decreased sex drive.
The presence of kidney failure in a patient, if it is not accompanied by a pronounced dysfunction of this organ, is not an indicator in order to reduce the dosage. Cases of over-reception of the agent have not been described to date. The capsules are theoretically capable of causing an acute drop in blood pressure.
If an overdose has occurred and the patient has symptoms of a pronounced decrease in blood pressure, it is necessary that he takes a horizontal position. Further, measures are taken to quickly restore blood pressure (make sure that hypertension does not appear). Measures such as emergency gastric lavage, the introduction of activated charcoal, laxatives (sodium sulfate and the like) into the gastrointestinal tract may be recommended. 
If, when the dosage is increased, there is no pronounced result, and the side effects intensify, the introduction of drugs that increase the volume of circulating blood is required. If necessary, pills that constrict blood vessels are prescribed. In patients with renal impairment, the excretory system should be monitored. In case of an overdose of the drug, dialysis is most likely ineffective, since almost all the substance binds to plasma proteins and such measures will not bring results.
Interaction with other drugs
When using Omnik with Atenolol, Nifedipine, Theophylline, no interaction was observed. Reception of Cimetidine together with Tamsulosin leads to an increase in the content of the latter in the blood plasma. The indicated administration of Furosemide, on the contrary, promotes a drop in the plasma concentration of the indicated drug.
Diazepam, Propranolol, Amitriptyline, Diclofenac, Warfarin do not lead to a change in the levels of Tamsulosin in human blood. In addition, the capsules of the specified preparation do not contribute to any change in the content of the above agents.
You must be careful when treating with other alpha-1-blockers at the same time. In this case, potentiation of the hypotensive effect is possible, which in total leads to severe hypotension.
Important instructions when taking the drug
If the patient taking these pills has severe dizziness and weakness, they should take a lying or sitting position until such symptoms completely disappear. Before starting the treatment of dysuric disorders caused by benign prostatic hyperplasia, you need to conduct a thorough examination of the patient. Such measures are necessary in order to exclude pathologies characterized by similar symptoms. After all, it can often be the case that urinary disorder develops for reasons that do not depend on the condition of the prostate. In such cases, Omnik Okas tablets will be not only useless, but also harmful.
Before treatment is started, it is necessary to conduct a blood test for the content of PSA in the blood, a prostate specific antigen. The same study is prescribed during treatment. In addition, a digital rectal examination of the prostate is highly recommended before and during therapy. 
If a patient is diagnosed with cataract, these tablets should not be prescribed, especially if surgical treatment of an eye disease is planned in the future. This is due to the fact that Omnik Okas can cause complications in the course of cataracts. In particular, this is a condition such as narrow pupil syndrome.
The drug can affect a person's ability to control complex mechanisms and drive a car. This feature of the action of the drug must always be taken into account when choosing the type of activity.
Similar means and form of release
Many patients are interested in what is the difference between Omnik Okas and Tamsulosin? These drugs are analogs, as a result of which they can be used in the treatment of urinary disorders.
Drugs with a similar effect are:
- Miktosin;
- Omsulosin;
- Glansin;
- Hyper-simple;
- Tamzelin;
- Tamsulon;
- Fokusin;
- Tulosin.
The drug is available in the form of tablets - round, convex on both sides. Each tablet is coated with a yellow or light brown coating. In addition to the active substance, the tablet contains auxiliary ingredients: macrogol, purified water (distilled), magnesium stearate, dye. Available in foil blisters. They are placed in a cardboard box.
The shelf life is 36 months. It is recommended not to use the drug after the specified period. Available only by prescription. It is necessary to store the product at a temperature not exceeding 25 ° C, protected from light and inaccessible to children.
The results of drug treatment
After reviewing the reviews about the drug, we can conclude that it has a beneficial effect on urinary function. Doctors characterize the drug as safe and effective. The correct intake of the medication ensures that there are no side effects when used.
Regular use of the medication in the dosage recommended by the doctor helps to increase the maximum rate of bladder emptying. At the same time, the discomfort characteristic of prostate adenoma during urination, cases of urinary retention in the bladder recede.
Long-term treatment with the drug improves the filling and emptying of the bladder. In this case, the urination process is largely normalized. In addition, this method of therapy significantly reduces the risk of life-threatening fluid retention. The need for surgery for prostate adenoma decreases, which is very important for elderly patients, in whom surgery may be associated with various complications.
The condition of those patients who, due to certain circumstances, cannot be operated on, is also improving, but nevertheless they suffer from pronounced symptoms of a violation of the natural processes of urination. In patients with end-stage prostate adenoma, this drug has a symptomatic effect, reducing the need for bladder catheterization and improving general condition.
When the medication is taken correctly, the likelihood of developing side effects is greatly reduced, making it safe to treat when compared to other medications.
So, the use of the drug Omnik Okas is justified in cases of urination disorders caused by benign prostatic hyperplasia. It has established itself as a highly effective drug that improves the condition of patients. Most experts recommend this remedy to anyone suffering from urinary dysfunction. At the same time, patients should be warned against self-therapy with this drug. Its reception must be agreed with the attending physician.
3D images
Composition and form of release
in a blister of PVC foil laminated and aluminum foil 10 pcs .; in a pack of cardboard 1 or 3 blisters.
Description of the dosage form
Round, biconvex, yellow to brownish-yellow film-coated tablet with "04" embossed on one side.
pharmachologic effect
pharmachologic effect - antidysuric, alpha-adrenolytic.Pharmacodynamics
Tamsulosin is a specific competitive blocker of postsynaptic α 1 -adrenergic receptors, especially the α 1A and α 1D subtypes, which are responsible for relaxing the smooth muscles of the prostate gland, the bladder neck and the prostatic urethra. Omnic Okas in a dosage of 0.4 mg increases the maximum urination rate, and also reduces the tone of smooth muscles of the prostate and urethra, improving urine flow, etc. reducing the severity of symptoms of emptying. Omnic Okas also reduces the severity of filling symptoms, in the development of which detrusor hyperactivity plays an important role.
With long-term therapy, the effect on the severity of symptoms of filling and emptying remains, which reduces the risk of developing acute urinary retention and the need for surgery.
Blockers of α 1A -adrenergic receptors can lower blood pressure by reducing peripheral resistance. When using the drug Omnik Okas in a daily dose of 0.4 mg, there were no cases of a clinically significant decrease in blood pressure.
Pharmacokinetics
Suction. Omnic Okas is a matrix-based controlled release tablet using a non-ionic gel. This dosage form provides a long and slow release of tamsulosin and a sufficient exposure with weak fluctuations in the concentration of tamsulosin in blood plasma for 24 hours.
Tamsulosin in the form of tablets Omnik Okas is absorbed in the intestine. Absorption is estimated at 57% of the administered dose. Food intake does not affect the absorption of the drug. Tamsulosin is characterized by linear pharmacokinetics. After a single oral intake on an empty stomach, the Omnik Okas tablet C max tamsulosin in plasma is reached on average after 6 hours. In an equilibrium state, which is achieved by the 4th day of administration, the concentration of tamsulosin in plasma reaches its highest value after 4-6 hours both on an empty stomach and after eating. Plasma Cmax increases from about 6 ng / ml after the first dose to 11 ng / ml at steady state. The lowest plasma concentration of tamsulosin is 40% of the maximum plasma concentration on an empty stomach and after meals. There are significant individual differences among patients with respect to plasma concentration of the drug after a single dose and multiple doses.
Distribution. Plasma protein binding is about 99%, Vd is small (about 0.2 l / kg).
Metabolism. Tamsulosin is slowly metabolized in the liver to form less active metabolites. Most of tamsulosin is present in blood plasma in unchanged form. The ability of tamsulosin to induce the activity of liver microsomal enzymes is practically absent (experimental data).
With hepatic failure, no dosage adjustment is required.
Excretion. Tamsulosin and its metabolites are mainly excreted in the urine, with approximately 4-6% of the drug excreted unchanged.
T 1/2 of tamsulosin in the form of tablets Omnik Okas with a single dose and in an equilibrium state - 19 and 15 hours, respectively.
Indications of the drug Omnik Okas
Benign prostatic hyperplasia (treatment of urinary disorders).
Contraindications
hypersensitivity to tamsulosin or any other component of the drug;
orthostatic hypotension;
severe liver failure.
Carefully - chronic renal failure (Cl creatinine<10 мл/мин), тяжелое нарушение функции печени, артериальная гипотензия.
Side effects
| Side effects | Often (≥1%, <10%) | Infrequently (≥0,1%, <1%) | Seldom (≥0,01%, <0,1%) | Rarely (<0,01%) |
| From the CCC | palpitations, orthostatic hypotension | |||
| From the digestive tract | constipation, diarrhea, nausea, vomiting | |||
| General state | asthenia | |||
| From the nervous system | dizziness (1.3%) | headache | fainting | |
| From the reproductive system | ejaculation disorders | priapism | ||
| On the part of the respiratory system, chest and mediastinum | rhinitis | |||
| On the part of the skin and subcutaneous tissue | rash, itching, urticaria | angioedema |
Some cases of intraoperative iris instability (narrow pupil syndrome) during cataract surgery are described, which increase the risk of complications during and after surgery.
Interaction
When tamsulosin was prescribed together with atenolol, enalapril, nifedipine or theophylline, no interactions were found. With simultaneous use with cimetidine, a slight increase in the concentration of tamsulosin in blood plasma was noted; with furosemide - a decrease, but this does not require a change in the dose of the drug Omnik Okas, since the concentration of the drug remains within the normal range. Diazepam, propranolol, trichloromethiazide, chlormadinone, amitriptyline, diclofenac, glibenclamide, simvastatin and warfarin do not alter the free fraction of tamsulosin in human plasma in vitro. In turn, tamsulosin also does not change the free fractions of diazepam, propranolol, trichloromethiazide and chlormadinone.
In research in vitro no interaction was found at the level of hepatic metabolism with amitriptyline, salbutamol, glibenclamide and finasteride. Diclofenac and warfarin may increase the rate of elimination of tamsulosin.
The simultaneous appointment of other blockers of α 1 -adrenergic receptors can lead to a hypotensive effect.
Method of administration and dosage
Inside, regardless of food intake, 1 table. Once a day. The duration of use is not limited, the drug is prescribed as continuous therapy. The tablet must be taken in its entirety; it must not be chewed. this can affect the prolonged release of the active substance.
Overdose
Symptoms: lowering blood pressure, compensatory tachycardia.
Treatment: symptomatic. BP and heart rate can recover when the patient assumes a horizontal position. In the absence of effect, you can use drugs that increase the BCC, and, if necessary, vasoconstrictor drugs. It is necessary to monitor kidney function. Dialysis is unlikely to be effective because tamsulosin binds intensively to plasma proteins.
To prevent further absorption of the drug, it is advisable to wash the stomach, take activated charcoal and osmotic laxatives.
Precautions
As with the use of other α 1 -adrenergic blockers, in the treatment of Omnik Okas, in some cases, a decrease in blood pressure can be observed, which in rare cases can lead to fainting. At the first signs of orthostatic hypotension (dizziness, weakness), the patient should sit or lie down and remain in this position until these signs disappear.
There is no withdrawal syndrome.
special instructions
During surgical interventions for cataracts while taking the drug, it is possible to develop a syndrome of intraoperative instability of the iris of the eye (narrow pupil syndrome), which must be taken into account by the surgeon for the preoperative preparation of the patient and during the operation.
Before starting therapy with Omnik Okas, the patient should be examined in order to exclude the presence of other diseases that can cause the same symptoms as benign prostatic hyperplasia. Before starting treatment and regularly during therapy, a digital rectal examination should be performed and, if required, the determination of a specific prostatic antigen.
In renal failure, no dose change is required.
Influence on the ability to drive vehicles and mechanisms
There are no data on the negative impact on the ability to drive vehicles and engage in potentially hazardous activities. However, due to the possibility of dizziness, until the patient's individual reaction is ascertained, one should refrain from activities requiring increased concentration and speed of psychomotor reactions, incl. from driving vehicles.
Terms of dispensing from pharmacies
On prescription.
Storage conditions of the drug Omnik Okas
At a temperature not exceeding 25 ° C.Keep out of the reach of children.
Shelf life of the drug Omnik Okas
3 years.Do not use after the expiration date printed on the package.
Synonyms for nosological groups
| ICD-10 heading | Synonyms of diseases according to ICD-10 |
|---|---|
| N40 Prostatic hyperplasia | Prostate adenoma |
| BPH | |
| Hypertrophy of the prostate | |
| Hypertrophy of the prostate | |
| BPH | |
| Dysuric disorders due to benign prostatic hyperplasia | |
| Dysuric disorder in benign prostatic hyperplasia | |
| Dysuria with prostate adenoma | |
| Benign prostatic hyperplasia | |
| Benign prostatic hyperplasia | |
| Benign prostatic hyperplasia stage 1 and 2 | |
| Stage 1 and 2 benign prostatic hyperplasia in combination with prostatitis | |
| Benign prostatic hyperplasia I degree | |
| Benign prostatic hyperplasia II degree | |
| Benign prostatic hypertrophy | |
| Disease of the prostate | |
| Acute urinary retention associated with benign prostatic hyperplasia | |
| Paradoxical ishuria |
Disruption of the normal functioning of the urinary system, as a rule, is accompanied by a mass of negative sensations.
Difficulty in urine excretion due to compression of the urethra by anything (hematoma, tumor, stone, enlargement of the prostate gland) in the medical environment is called dysuria. For the treatment of this problem caused by prostatic hyperplasia, Omnik drugs are intended.
In this article, we will consider why doctors prescribe Omnik OKAS, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Omnik OKAS can be found in the comments.
Composition and form of release
Omnic Okas is produced in the form of tablets in a controlled release shell No. 10 or No. 30 in a package.
- active substance: tamsulosin hydrochloride 0.4 mg,
- excipients: macrogol 8000, macrogol 7,000,000, magnesium stearate; shell composition - yellow opadry 03F22733 (hypromellose, macrogol 8000, iron dye yellow oxide (E172)).
Clinical and pharmacological group: a drug used for urination disorders associated with benign prostatic hyperplasia. Alpha1-blocker
Omnik Okas and Omnik - what's the difference?
Omnic Okas is a matrix-based controlled release tablet using a non-ionic gel, i.e. the dose of Tamsulosin is released for a long time and slowly and during the day provides a constant effect of the drug. That improves the tolerability of the drug, reduces the likelihood of side effects. If the patient has complaints about the tolerance of Omnik, then discuss with the doctor the possibility of switching to Omnik Okas.
Indications for use
Omnic OKAS is mainly prescribed for the treatment of urinary disorders associated with benign prostate adenoma.
pharmachologic effect
The drug Omnik Okas from the group of alpha1-adrenergic blockers, it blocks postsynaptic alpha1-adrenergic receptors, which are responsible for the relaxation of the smooth muscles of the prostate gland, in addition, the neck of the bladder, as well as the urethra, namely, its prostatic part.
The medication increases the rate of urination, lowers the tone of the muscles of the prostate gland, in addition, improves the outflow of urine, thereby significantly reducing the severity of symptoms. Under the influence of the drug, the risk of developing acute urinary retention decreases and the need for surgery is eliminated.
Instructions for use
According to the instructions for use, the Omnik OKAS tablet should be taken whole, without chewing, in order to avoid affecting the prolonged release of the active substance.
- Assign inside 400 mcg (1 tab.) 1 time / day, regardless of food intake.
The duration of use is not limited, the drug is prescribed as continuous therapy.
Contraindications
You can not use the drug in such cases:
- Orthostatic hypotension.
- Severe liver failure.
- Hypersensitivity to tamsulosin or any other component of the drug.
With caution - chronic renal failure (creatinine clearance below 10 ml / min), arterial hypotension.
Side effects
Among the side effects of this remedy are the following:
- Sleep disorders (in the form of insomnia).
- Increased heart rate.
- Inflammation of the nasal mucosa.
- Decreased sex drive;
- Dizziness, sometimes severe headache.
- Fainting.
- Disorders of the digestive system in the form of constipation or diarrhea.
- Ejaculation disorder (retrograde semen movement). Pain in the penis (priapism symptoms).
- Allergic reactions in the form of a rash, sometimes - urticaria and very rarely - Quincke's edema.
- Increased blood pressure with pain in the chest area.
Analogs Omnik OKAS
Analogs of this drug are divided into remedies with an identical active ingredient: Adenorm, Omnik, Proflosin, Omsulozin, Alfatam, Revokarin, Omniprost, Sonisin, Fokusin, Urofrin, etc., as well as drugs with a similar main effect: Avodart, Dalfaz, Alfuzosin, Dalfuzin, Alfirum, Kornam, Urorek, Alfater, Setegis, etc.
Description of the dosage form
Release form, composition and packaging
Modified release capsules hard gelatinous, size No. 2, orange body marked "701" and a graphic image of the company's trademark, olive green lid marked "0.4"; the contents of the capsules are granules from white to white with a light yellow shade.
Excipients: microcrystalline cellulose, copolymer of methacrylic acid (type C), polysorbate 80, sodium lauryl sulfate, triacetin, calcium stearate, talc, gelatin, indigodin, titanium dioxide, iron oxide yellow, iron oxide red.
10 pieces. - blisters (1) - cardboard packs.
10 pieces. - blisters (3) - cardboard packs.
Clinical and pharmacological group
A drug used for urination disorders associated with benign prostatic hyperplasia. Alpha 1 -adrenergic blockerpharmachologic effect
Omnic selectively and competitively blocks postsynaptic α 1A -adrenergic receptors located in the smooth muscles of the prostate gland, bladder neck and prostatic urethra, as well as α 1D -adrenergic receptors, mainly located in the body of the bladder. This leads to a decrease in the tone of the smooth muscles of the prostate gland, bladder neck and prostatic urethra and an improvement in detrusor function. This reduces the symptoms of obstruction and irritation associated with benign prostatic hyperplasia. As a rule, the therapeutic effect develops 2 weeks after the start of taking the drug, although in some patients, a decrease in the severity of symptoms is noted after taking the first dose.
Omnik's ability to affect α 1A -adrenergic receptors is 20 times greater than its ability to interact with α 1B -adrenergic receptors, which are located in vascular smooth muscles. Due to this high selectivity, the drug does not cause any clinically significant decrease in systemic blood pressure in both patients with arterial hypertension and patients with normal baseline blood pressure.
Pharmacokinetics
Suction
After oral administration, tamsulosin is rapidly and almost completely absorbed from the gastrointestinal tract. The bioavailability of the drug is about 100%. Absorption slows down somewhat after eating. The same level of absorption can be achieved if the patient takes the drug every time after the usual breakfast.
The pharmacokinetics of tamsulosin is linear. After a single dose of the drug inside at a dose of 400 μg, the C max of the active substance in plasma is reached after 6 hours.
Distribution
After repeated ingestion of the drug in a daily dose of 400 μg, C ss is reached by the 5th day, while its value is 2/3 higher than the C max value after a single dose of the drug.
Plasma protein binding - 99%. V d is insignificant and amounts to 0.2 l / kg.
Metabolism
Tamsulosin is slowly biotransformed in the liver to form less active metabolites. Most of the active substance is present in the blood unchanged.
In experimental studies, the ability of tamsulosin to slightly induce the activity of liver microsomal enzymes was revealed.
Withdrawal
Tamsulosin and its metabolites are excreted mainly in the urine, 9% of the dose is excreted unchanged.
T 1/2 with a single dose of 400 mcg of tamsulosin after meals - 10 hours, after multiple doses - 13 hours.
Indications for the use of the drug
- treatment of dysuric disorders in benign prostatic hyperplasia.
Dosage regimen
The drug is prescribed at a dose of 400 mcg (1 capsule) 1 time / day.
Capsules are taken orally after breakfast with plenty of water. It is not recommended to chew the capsule.
With minor and moderate violations of liver function, as well as with impaired renal function, dose adjustment is not required.
Side effect
On the part of the cardiovascular system: rarely - dizziness; in isolated cases - orthostatic hypotension, palpitations, tachycardia.
From the side of the central nervous system: in isolated cases - headache, asthenia.
From the reproductive system: rarely - retrograde ejaculation.
From the digestive system: rarely - nausea, vomiting, diarrhea, constipation.
Allergic reactions: in some cases - skin rash, itching, angioedema.
Contraindications to the use of the drug
- orthostatic hypotension (including a history);
- severe liver failure;
- hypersensitivity to drug components.
FROM caution
Application for violations of liver function
Contraindicated in severe hepatic failure.
Application for impaired renal function
FROM caution the drug should be prescribed for severe renal failure (CC less than 10 ml / min).
special instructions
Omnik should be used with caution in patients with a predisposition to orthostatic hypotension. At the first signs of orthostatic hypotension (dizziness, weakness), the patient should be seated or laid down.
Before starting to use the drug, it is necessary to verify the diagnosis and exclude the presence of other diseases that can cause similar symptoms.
A digital rectal examination and, if necessary, determination of specific antigen of the prostate gland (PSA) should be performed before and regularly during therapy.
Overdose
There were no cases of acute drug overdose.
Symptoms: theoretically, the occurrence of acute arterial hypotension and compensatory tachycardia is possible.
Treatment: carry out symptomatic therapy: giving the patient a horizontal position, if necessary - the introduction of volume-replacing solutions or vasoconstrictor drugs. To prevent further absorption of tamsulosin, gastric lavage, intake of activated charcoal or an osmotic laxative is possible. It is necessary to monitor kidney function. Dialysis is unlikely to be effective because tamsulosin is in active connection with plasma proteins.
Drug interactions
With the simultaneous use of Omnik with cimetidine, there was a slight increase in the concentration of tamsulosin in the blood plasma, and with furosemide, a decrease in concentration, but this does not require a change in the dose of Omnik.
When used simultaneously with Omnik, diclofenac and warfarin may slightly increase the rate of elimination of tamsulosin.
The simultaneous use of Omnik with other alpha 1 -adrenergic blockers can lead to a pronounced decrease in blood pressure.
With the simultaneous administration of Omnik with atenolol, enalapril, nifedipine, drug interactions were not found.
Diazepam, propranolol, trichloromethiazide, chlormadinone, amitriptyline, diclofenac, glibenclamide, simvastatin and warfarin do not alter the free fraction of tamsulosin in plasma in vitro. In turn, tamsulosin also does not change the free fractions of diazepam, propranolol, trichloromethiazide and chlormadinone.
In in vitro studies, no interaction was found at the level of hepatic metabolism with amitriptyline, salbutamol, glibenclamide and finasteride.
Terms of dispensing from pharmacies
The drug is available by prescription.
Storage conditions and periods
The drug should be stored at temperatures between 15 ° and 25 ° C. The shelf life is 4 years.
"Disruption of the normal functioning of the urinary system, as a rule, is accompanied by a mass of negative sensations. Difficulty in urine excretion due to compression of the urethra by anything (hematoma, tumor, stone, enlargement of the prostate gland) in the medical environment is called dysuria. For the treatment of this problem caused by the drugs "Omnik" and "Omnik Okas" are intended. What is the difference between them, and whether there is any at all, will be discussed below.
The main composition and form of release of medicines
The manufacturer offers the drug "Omnik" to consumers in an encapsulated form. Omnik capsules with modified release contain 400 μg of tamsulosin hydrochloride as the main active ingredient.
Cellulose, triacetin, yellow and red iron oxides, calcium stearate can be distinguished as auxiliary components. The orange body of the capsule is covered with an olive-green lid. The granules are white to light yellow in color.
As for the medicine "Omnik Okas", the instructions for use inform that the product is available in the form of controlled release tablets. The same tamsulosin hydrochloride acts as the main active ingredient. The auxiliary components are somewhat different from those that are part of Omnik: macrogol (8,000 and 7,000,000), magnesium stearate and purified water. Tablets are round, biconvex with a color from yellow to brownish-yellow.
Pharmacodynamics
Reception of "Omnik" stimulates a decrease in the tension of the smooth muscles of the bladder neck, the tone of the prostate gland decreases. Against the background of drug treatment, symptoms of irritation (filling) and obstruction (emptying) of the bladder, accompanying prostatic hyperplasia, become less pronounced.
"Omnik" is characterized by high selectivity, as a result of which it does not contribute to a decrease in blood pressure either in patients with normal blood pressure or in hypertensive patients.
The pharmacological effect on a man's body is practically the same for the medicines "Omnik" and "Omnik Okas". What is the difference, and is there any difference for those suffering from high blood pressure? Both drugs, when taken 400 mcg per day, do not cause a noticeable increase in blood pressure indicators.
Indications and contraindications
"Omnik" and "Omnik Okas" instructions for use recommends using for the treatment of dysuric abnormalities caused by benign prostatic hyperplasia.
As for contraindications, it should be said about the inadmissibility of taking the drug by those patients who suffer from orthostatic arterial hypotension (a significant drop in blood pressure when a person stands up), because this can lead to a decrease in the blood supply to the brain and fainting. In addition, drugs are not prescribed in the presence of severe renal failure and in individual hypersensitivity to the active or auxiliary components. For those who suffer from renal failure, Omnik and Omnik Okas are prescribed with great care. What is the difference between them? Capsules "Omnik" are taken with severe degrees of the disease, and "Omnik Okas" - with a chronic form and creatine clearance below 10 ml / min.
Application and dosage
How do they drink Omnik? Instructions for use (the price of the drug will be discussed later) states that this drug should be taken once in a daily volume of 400 mcg. It is advisable to take the capsule after breakfast, do not chew and drink plenty of liquid. Small or moderate deviations from the norm in the functioning of the liver and kidneys are not a basis for dose adjustment.
"Omnik Okas", the price of which is slightly higher than that of the drug "Omnik", the instruction allows you to take it regardless of the meal.
The daily volume of the medication is 1 tablet (400 μg). It is not recommended to chew the medicine, as this may affect the prolonged release of the main active ingredient.
Exceeding the permissible dose
It is necessary to carefully follow the recommendations of the attending physician in order to avoid an overdose of medicines "Omnik" and "Omnik Okas". What is the difference in symptoms? To date, no cases of acute overdose with Omnik have been recorded. Theoretically speaking, there is a likelihood of a fall in blood pressure and the development of compensatory tachycardia. Acceptance of large volumes of Omnik Okas causes arterial hypotension in the acute stage.
Treatment in both cases consists of bringing the patient to a horizontal position, taking sorbents (activated charcoal has proven itself best) or an osmotic laxative. In order to prevent the further absorption of tamsulosin, gastric lavage is recommended. If, in case of poisoning with the Omnik Okas remedy, there is no proper effect from all the above measures, it is permissible to use vasoconstrictors and drugs that increase the BCC. The likelihood that dialysis will give any tangible effect is low, since tamsulosin binds quite intensively to plasma proteins.
Side effects
The use of "Omnik" can cause some undesirable effects on the part of different systems of the human body. CVS can manifest itself with dizziness, increased heart rate, orthostatic hypotension can sometimes be observed.
A possible reaction of the nervous system is headaches, impotence. From the gastrointestinal tract, diarrhea, constipation, nausea, and vomiting may occur. Not often, but it happens that the reproductive system reacts with development (sperm is thrown into the bladder).
We examined the phenomena that "Omnik" can cause (analogues exist cheaper than it, but they also contribute to the development of such reactions). "Omnik Okas", in addition to all of the above, can cause fainting (it happens quite rarely), priapism (long and painful erection, not associated with sexual arousal). Sometimes patients develop rhinitis. Allergic reactions caused by both drugs are similar: urticaria, skin rash, itching, angioedema (rare).
What to look for?
If the patient has a predisposition to orthostatic hypotension, Omnik should be used with caution. At the first signs of the development of this condition, the person should be laid down or at least seated. In addition, you should be sure of the diagnosis in order to exclude the presence of diseases that cause the same symptoms as prostatic hyperplasia.
Many patients are interested in what is better than Omnik, is more effective and gives faster results? With the use of Omnik Okas it is possible to achieve the desired effect sooner. However, in the case of using this drug, it is able to overcome the threshold, after which fainting occurs.
If, against the background of treatment with the medicine "Omnik Okas", a surgical procedure is performed, there is a possibility of developing a narrow pupil syndrome.
When treating with both drugs, it is important at the beginning and throughout the treatment to regularly carry out rectal examination (digital) and, if necessary, determine the specific antigen of the prostate gland.
Price range
Omnik capsules can be purchased today in the pharmacy chain for 360-370 rubles (we are talking about 10 capsules). A package of 30 pieces is available to consumers at a price of 740-795 rubles. For 100 capsules, you will have to pay from 2,085 to 2,175 rubles.
The price of the drug "Omnik Okas" is much higher. A blister of 10 tablets will cost the consumer 560-620 rubles. A package of 30 pieces will cost even more: you will have to pay from 1,520 to 1,690 rubles for it.
In general, we can say that the medication, let's say, is not entirely cheap. However, its acquisition does not carry any particularly sensitive consequences for a consumer's wallet with average financial capabilities.
Medicinal product analogues and doctors' opinions
Currently, there are many medicines that have an effect similar to the effect of the Omnik Okas and Omnik products. Analogues are cheaper than the original product, and it is quite easy to purchase them in the pharmacy network.
The most popular drugs include Omsulozin (30 tablets cost about 470 rubles), Proflosin (30 tablets will cost 395-450 rubles, 100 - 1130-1160 rubles).
In addition, Tamsulozin Teva is also in demand on the pharmaceutical market today. It can be purchased for 450-560 rubles (30 tablets).
As for the opinions on the medication, medical professionals characterize it as a very, very effective remedy for reducing the tone of the prostate, which greatly facilitates the process of urine outflow. In addition, both doctors and patients report that treatment with Omnik and Omnik Okas significantly reduces the intensity of unpleasant symptoms such as obstruction and irritation of the bladder.
Also important is the fact that these drugs are able to dramatically improve the quality of life of that part of the strong half of humanity who suffers from prostate diseases. It is only important to pay attention to uncharacteristic symptoms and, without waiting for it to "pass by itself," seek medical help, and then follow all the recommendations of the attending doctor.
