Transparent oily liquid, light yellow
colors;
pharmachologic effect
An estrogenic agent that stimulates the development of the uterus and secondary sexual characteristics when they are underdeveloped.
Estrone is a natural follicular hormone that regulates the normal development of the female reproductive system and is produced in the ovaries with the onset of puberty before the onset of menopause.
The action is mediated through estrogen-sensitive receptors of the genitals, mammary glands, hypothalamus and pituitary gland. It has a specific estrogenic effect - it stimulates the proliferation of the endometrium (in the fallopian tubes, cervix, vagina, external genitalia, excretory ducts of the mammary glands), the development of the uterus and secondary female sexual characteristics when they are underdeveloped, eliminates or reduces the severity of disorders that occur in a woman’s body in connection with insufficient function of the gonads during menopause or after gynecological operations. Together with progesterone, it participates in the regulation of the menstrual cycle and the function of childbirth.
In small doses it activates the secretion of follicle-stimulating hormone, in large doses it inhibits it, and also retains water and sodium ions in the body, inhibiting erythropoiesis. It has a hypocholesterolemic effect, improves glucose utilization, and increases the sensitivity of peripheral tissues to insulin.
Pharmacokinetics
Well absorbed. High plasma levels persist for 4-5 days. Metabolized mainly in the liver (partially in the lungs, adipose tissue), excreted in bile, reabsorbed in the intestine and again enters the liver through the portal system. It is excreted in the form of conjugates mainly by the kidneys. The rate of excretion depends on the physiological state (pregnancy, phase of the ovarian menstrual cycle), age and other factors.
Indications for use
Conditions caused by insufficient ovarian function: primary and secondary amenorrhea, hypoplasia of the genital organs and insufficient development of secondary sexual characteristics, menopausal and post-castration disorders, infertility due to a decrease in estrogenic ovarian function, weakness of labor, post-term pregnancy.
Contraindications
Hypersensitivity, neoplasms (malignant and benign) of the genital organs and mammary glands in women under 60 years of age, mastopathy, inflammatory diseases of the female genital organs, vaginal and uterine bleeding of unknown etiology, predisposition to uterine bleeding, hyperestrogenic phase of the menopause, hepatic and/or or renal failure, thrombophlebitis and recurrent thromboembolism in history, pregnancy.
Directions for use and doses
Prescribed intramuscularly. The dose is set individually.
Primary amenorrhea with underdevelopment of the genital organs and secondary sexual characteristics. Prescribe 1-2 ml daily or every other day for 1-2 months or more (until noticeable enlargement of the uterus). Then progesterone is prescribed (intramuscular, 5 mg daily for 6-8 days). If necessary, courses of hormone therapy are repeated.
Secondary amenorrhea. Prescribe 1 ml daily for 15-16 days, followed by progesterone for 6-8 days. If there is no lasting effect, the course of treatment is repeated.
Hypo- and oligomenorrhea, algomenorrhea, infertility caused by ovarian hypofunction or underdevelopment of the uterus. After the end of menstruation, 0.5-1 ml is prescribed daily for 15-16 days, then, if indicated, progesterone is prescribed for 6-8 days. The course of treatment can be repeated at the same time after the end of menstruation. Functional disorders caused by the onset of menopause and oophorectomy (depression, angioedema, etc.). Prescribe 0.5-1 ml daily or every 1-2 days in courses of 10-15 injections. The course of treatment is repeated if symptoms recur. Doses should be selected strictly individually (selection of minimum effective doses is necessary) depending on the phase of the menopausal period and the severity of symptoms.
Weakness of labor and post-term pregnancy. Prescribe 4-5 ml 2-3 hours before using birth stimulants.
Side effect
Nausea, vomiting, headache, dizziness, allergic reactions, eyelid swelling, erythropenia. With long-term use, uterine bleeding, ovarian sclerosis, disturbances in the metabolism of sodium, calcium and water, and congestive jaundice are possible.
Overdose
Symptoms: increased headache, nausea. With prolonged use, uterine bleeding is possible. Treatment: symptomatic.
Interaction with other drugs
Enhances the effect of hypocholesterolemic, antiarrhythmic, antihypertensive drugs, diuretics, anticoagulants, tricyclic antidepressants, glucocorticoids, thyroid hormones. The effect of estrone is enhanced by folic acid and thyroid medications, and weakened by antiestrogenic drugs (clomiphene, etc.) used to treat infertility, phenobarbital, rifampicin and other monooxygenase inducers. The concentration of the drug in the blood is reduced by ampicillin, chloramphenicol, tetracycline, neomycin, sulfonamides; increases - ascorbic acid.
Features of application
Treatment with the drug should be carried out under the supervision of a physician.
The drug is prescribed with caution for arterial hypertension, previous thromboembolic diseases, epilepsy, depression (including a history), gallbladder diseases, otosclerosis.
Before starting to take the drug, you should undergo a thorough general medical and gynecological examination, including examination of the mammary glands. Similar
studies must be carried out every 6 months of treatment. In case of acute visual and hearing impairment, acute thrombosis, if signs of phlebitis, bile stagnation or hepatitis appear, the use of the drug must be discontinued. Pregnancy and lactation. During pregnancy and in the early postpartum period, the use of the drug is discontinued. During treatment, breastfeeding should be discontinued.
Application in pediatrics. In childhood and adolescence (before the end of bone growth), the drug should be used with caution due to the possibility of developing disorders of the skeletal system.
In case of crystal precipitation, the contents of the ampoule should be heated in a boiling water bath for 15 to 20 minutes before injection. If the crystals disappear and the solution becomes transparent, and when cooled to (37±1)°C the crystals do not fall out again, the drug is suitable for use.
Estrone INN
Description of the active substance (INN) Estrone* (Estrone*)
Pharmacology: pharmachologic effect - estrogenic . Regulates the normal development of the female reproductive system and the menstrual cycle. Interacts with cytoplasmic receptors in the genitals, mammary glands, hypothalamus and pituitary gland. Causes proliferation of the endometrium, stimulates the development of the uterus, fallopian tubes, secondary female sexual characteristics, reduces menopausal disorders, affects the formation of the skeleton, tone and elasticity of urogenital structures, causes changes in the epiphyses of tubular bones. Reduces the release of pituitary gonadotropins.
Metabolism and inactivation occur primarily in the liver (estriol is a low-active metabolite), excreted in bile, reabsorbed in the intestine and re-entered the liver through the portal system.
Indications: Functional deficiency, menopausal dysfunction and ovarian hypoplasia, primary and secondary amenorrhea, post-castration syndrome, infertility, atrophic vaginitis, postmenopausal osteoporosis, breast cancer with metastases, prostate cancer (palliative measure), secondary chorea, dyskinesia (induced by levodopa) , male hypersexuality with deviant sexual behavior.
Contraindications: Hypersensitivity, malignant and benign tumors, mastopathy, endometritis, vaginal and uterine bleeding of unknown etiology, thrombophlebitis and recurrent thromboembolism in history, pregnancy.
Restrictions on use: Epilepsy, migraine, renal failure, depression, incl. history, cholestasis of pregnancy, circulatory failure, dysfunction of the liver, kidneys, gallbladder disease, hypercalcemia, thrombophilic conditions, childhood and adolescence (until the end of bone growth).
Side effects: Uterine bleeding, dysmenorrhea, amenorrhea, premenstrual-like syndrome, increase in the size of uterine fibroids, vaginal candidiasis, changes in cervical secretion, pain, enlargement and discharge from the mammary glands, nausea, vomiting, cramping pain and bloating, cholestatic jaundice, myocardial infarction, pulmonary embolism, thrombophlebitis, cystitis-like syndrome, headaches, dizziness, depression, folic acid deficiency, megaloblastic anemia, etc., hypercalcemia (in patients with metastatic bone lesions), edema, chloasma, erythema (multiform, nodular), hemorrhagic rashes, hair loss, hirsutism, changes in libido.
Interaction: Ampicillin, chloramphenicol, tetracycline, neomycin, sulfonamides reduce the concentration in the blood (reduce enterohepatic circulation), ascorbic acid increases. Enhances the effect of tricyclic antidepressants (slows down inactivation in the liver), glucocorticoids, and thyroid hormones. Phenobarbital, rifampicin and other monooxygenase inducers reduce estrogenic activity.
Overdose: Manifested by nausea, uterine bleeding.
Treatment: symptomatic.
Directions for use and dosage: IM. For replacement therapy - 0.1-1 mg per week, once or in several doses, from the 1st to the 25th day of each month, with a 7-10-day break, 2-3 courses. Senile vaginitis - 0.1-0.5 mg 2-3 times a week, for 3 weeks, then a 7-day break. Dysfunctional uterine bleeding - 2-5 mg daily (for several days). Palliative treatment of prostate cancer - 2-4 mg 2-3 times a week, for 3 months or more.
Precautions: Treatment can only be carried out under close medical supervision. With long-term continuous administration of large doses, the risk of developing endometrial hyperplastic processes increases, therefore intermittent courses of small doses in combination with gestagens are preferable. If pregnancy occurs during the treatment period, the potential risk to the fetus must be explained to the patient.
Folliculin is a drug belonging to the group of hormones. It is a natural ovarian hormone or follicular hormone and is widely used to treat ovarian failure.
Active substance
Estrone (Oestronum).
Release form and composition
The drug is available in the form of an oil solution.
Indications for use
Indications for use of the drug:
- menopause;
- insufficiency of ovarian function (virile hypertrichosis, primary and secondary amenorrhea, hypogonadism in girls, dysmenorrhea);
- infertility;
- weak labor activity;
- post-term pregnancy;
- suppression of lactation.
Folliculin is also effective as a cure for certain skin diseases: it helps get rid of acne caused by improper functioning of the ovaries, and from hypertrichosis - increased development of hair that is not characteristic of gender and age, as well as from some other diseases.
Contraindications
Contraindications to the use of the drug: mastopathy, endometritis, malignant neoplasms in women under 60 years of age. Folliculin is not prescribed if there is an increased risk of developing uterine bleeding and in the hyperestrogenic phase of menopause, when the release of female sexual hormones is already increased.
Instructions for use Folliculin (method and dosage)
The drug solution is administered intramuscularly. It is recommended to warm the ampoule in your hands before use. When crystals appear, the ampoule is heated in a water bath for 15-20 minutes.
For the treatment of underdevelopment of the genital organs and primary amenorrhea, 10,000-20,000 units are prescribed daily for 1-2 months. Then Progesterone is prescribed intramuscularly at a dosage of 5 mg per day.
For secondary amenorrhea, 10,000 units are prescribed daily for 15 days. If necessary, the course can be repeated.
For the treatment of algomenorrhea, oligomenorrhea and infertility, 5,000-10,000 units per day are prescribed for 10-15 days.
To relieve acute signs of menopause, 5,000-10,000 units are prescribed daily. The course of treatment is 10-15 injections.
In case of weak labor, 40,000-50,000 units of Folliculin are administered before the administration of labor-stimulating drugs.
Side effects
Taking the drug may cause the following side effects:
- vomiting and nausea;
- headache and dizziness;
- allergy;
- erythropenia;
- uterine bleeding;
- ovarian sclerosis;
- violation of water-salt metabolism.
Overdose
An overdose of Folliculin is manifested by increased nausea, headache and the appearance of uterine bleeding. In this case, symptomatic treatment is used.
Analogues of Folliculin
Analogs by ATX code: no.
Medicines with a similar mechanism of action (matching level 4 ATC code): Estrone, Estradiol, Estriol.
Do not decide to change the drug on your own; consult your doctor.
pharmachologic effect
The effect of Folliculin on the body is similar to the effect of estrogens - female sex hormones that are produced by the ovaries and adrenal cortex. Estrogen is responsible for the development of the genital organs and secondary sexual characteristics in women. This hormone promotes the growth or proliferation of the endometrium (the inner layer of the uterus). Together with the corpus luteum hormone, Progesterone, Folliculin takes an active part in regulating menstrual function.
special instructions
Information is absent.
During pregnancy and breastfeeding
The drug is contraindicated during pregnancy.
In childhood
The drug is contraindicated in children under 14 years of age.
In old age
Information is absent.
Drug interactions
Folic acid and thyroid hormones enhance the therapeutic effect of estrone. Rifampicin and phenobarbital reduce its effectiveness.
Estrone enhances the effect of hypocholesterolemic, antihypertensive and antiarrhythmic drugs, thyroid hormones, diuretics, anticoagulants, glucocorticoids and antidepressants.
Tetracycline, chloramphenicol, sulfonamides, ampicillin and neomycin contribute to a decrease in estrone concentration. Ascorbic acid increases the concentration of the hormone in the blood.
Conditions for dispensing from pharmacies
Folliculin is available by prescription.
Storage conditions and periods
The drug should be stored at a temperature of 8-15°C. Shelf life – 5 years.
Folliculinum is a homeopathic preparation made from one of the types of estrogen - the female sex hormone of the follicular tissues of the ovaries) - estrone.
The role of estrone is to promote the normal course of the first half of the menstrual cycle before ovulation:
- the hormone stimulates the growth and development of follicles and the eggs they contain, the maturation and growth of the endometrium (the inner layer of uterine tissue);
- has a tonic effect on other structures of the genital organs and enhances the secretion of cervical mucus to create favorable conditions for possible fertilization already in the second half of the menstrual cycle;
- at the same time, the woman’s emotional state improves.
This is interesting. Folliculinum has been used for about 30 years, relatively recently (in comparison, oral contraceptives began to be used more than 70 years ago).
Indications for use
Folliculinum is used for disorders leading to disruption of the ovulation process. These can be both psychological factors and organic health problems associated either with infection, or with reactive lesions of the reproductive and reproductive system, or due to diseases of other systems and organs. Folliculinum is used as part of complex therapy in the treatment of infertility.
Use of Folliculinum in the treatment of infertility
An integrated approach to the issue of infertility, taking into account all the symptoms, heredity and history of the disease, allows us to approach the problem more objectively, to treat the body as a whole, and not just its specific organs.
The goal is general improvement, which in the future will help solve the problem of childbirth. An experienced homeopath combines and successfully uses in the treatment of both female and male infertility according to the scheme together with C200 - Carcinosin 200C, 6C (Sepia 6C), 200C (Thuja 200C), Medorrinum 200C, Borax 30C (Borax 30C), Natrum muriaticum 30C (Natrum muriaticum 30C), Pulsatilla 12C (Pulsatilla 12C), Nux vomica 30 C (Nux vomica 30C) and other drugs that also create optimal conditions for conception.
Folliculinum can be prescribed by a doctor to eliminate the undesirable consequences of irrational hormone therapy, long-term use of oral contraceptives and anabolic steroids. Source: flickr (Eugene Evehealth).
Psychological type Folliculinum
The main feature of the psychological type Folliculinum is oppression, oppression, be it physical, through physical violence or illness, be it psychological - difficult life circumstances, overbearing parents, spouse, colleagues, etc.
Such patients feel like debtors, are afraid of the prospect of not meeting someone’s expectations, try to please everyone even at the cost of their own health and dignity, overestimating their physical strength. They feel “like a squeezed lemon” and have a tendency to depression, melancholy, and emotional excitability. Prone to self-criticism.
Patients often do not have their own opinions and are easily influenced by others. At the same time, they feel constantly empty.
Properties of Folliculinum
Folliculinum promotes gentle natural recovery of the body, increasing vitality by restoring normal hormonal regulation of the body and enhancing biochemical processes during the restoration of damaged tissues.
This helps to normalize the hormonal function of the reproductive system during early or late puberty.
For diseases of the genital organs, it reduces inflammatory reactions, pain, the proliferation of papillomas, condylomas, and tumors. Strengthens local immunity.
The product mobilizes all restorative functions, promoting rapid recovery and a return to normal life after protracted illnesses.
Folliculinum helps to establish harmony in the emotional-volitional sphere in patients with the appropriate psychological type, improves mood, improves the ability to adequately assess the situation and calculate one’s own strengths, and helps increase self-esteem.
Indications for use
Folliculinum is used for the following diseases:
- (delayed menstruation, painful flow, heavy or scanty bleeding);
- Sexual infantilism in both men and women;
- Gynecomastia (enlargement of breast tissue) in men and virile syndrome (manifestation of male sexual characteristics) in women;
- Infertility;
- Premenstrual syndrome with severe pain in the mammary glands, stool disturbances in the form of alternating diarrhea and constipation, bloating, cramps. In case of disturbances in the psycho-emotional state in the period between ovulation and menstruation;
- Chronic inflammatory processes in the pelvic organs and external genital organs (salpingitis, oophoritis, vulvo-vaginitis, cystitis, urethritis, etc.);
- Congenital polycystic ovary syndrome;
- Benign neoplasms of the genital organs (fibromas, fibromyomas, cysts, polyps, condylomas and papillomas);
- The period of menopause and menopause to eliminate hot flashes, dysfunctional uterine bleeding, to normalize the general physical and psycho-emotional state;
- The period of recovery after prolonged illness.
Folliculinum is a remedy for the treatment of predominantly female genital organs. But the treatment of male hormonal disorders and related diseases is also included in the range of therapeutic properties of this homeopathic remedy. Folliculin is a hormonal drug that has an estrogenic effect. Used in the treatment of hormonal disorders in women, it may cause side effects and therefore requires a prescription from a physician.
Composition and release form
The presented medicinal product is produced in the form of an injection solution - an oil type, in ampoules of 1 ml.
Composition of folliculin:
- estrogens;
- water for injections;
- aloe oil
Pharmacy chains also sell analogues of this product - crystal var, menformon, estrogenone, gynestril, telestrin and others. They all have the same pharmacological action.
Indications for use
Folliculin is prescribed for various diseases that are caused by disturbances in the functioning of a woman’s hormonal system. For example, the drug is quite effective for virile hypertrichosis (increased amount of body hair), acne (not teenage type), massive outbreak of boils during reproductive age, and others.
The main purpose of folliculin is recommended for gynecological diseases of an inflammatory nature - endometriosis, chronic adnexitis, polycystic ovary syndrome, as well as for primary amenorrhea (absence of menstruation), underdevelopment of the uterus.
If the patient has a menstrual cycle disorder, then the presented drug can be prescribed as one of the components of complex therapy.
Folliculin - instructions for use and dosage
In case of diagnosed menstrual irregularities, it is recommended to carry out the following therapy with the drug:
- In case of primary amenorrhea and the absence of secondary sexual characteristics - 2-4 ml daily intramuscularly for 3-4 months, then inject progesterone in the amount of 1 ml once a day for a week.
- For secondary amenorrhea (when there is no menstruation for more than 6 months) - 4 ml daily for three weeks, then you should take a course of progesterone injections for 3-4 days.
- For any disturbances in the functioning of the reproductive system caused by hormonal dysfunction - 4 ml daily for 15 days.
- In case of surgical removal of the ovaries or the onset of menopause, folliculin is prescribed in the amount of 5 ml daily for a week. If necessary, the course is repeated, but it is necessary to closely monitor the woman’s condition—the appearance of signs of an overdose is a reason to immediately stop therapy.
In all cases of prescribing folliculin, mandatory injections of progesterone should be provided - to find out the patient’s loyalty to this drug.
Contraindications
It is strictly prohibited to prescribe the drug in question for diagnosed tumors of the genital organs and mammary glands in women under the age of 50 - this can cause their increased growth, and if the nature of the tumors is malignant, then accelerate the process of division of cancer cells.
Folliculin is also contraindicated in case of dysfunctional uterine bleeding, menopause with the release of large amounts of female hormones and focal lumps in the breast (mastopathy).
Special instructions for use and warnings
Folliculin is an oil solution for intramuscular injection, so before the procedure you must perform the following steps:
- warm up the ampoule by holding it in your hands;
- shake the ampoule and make sure there are no sediments or foreign impurities;
- inject folliculin deeply intramuscularly, slowly.
When carrying out numerous injections, it is necessary to strictly observe the rules of sterility - the rapid development of an abscess with purulent contents is possible. If lumps appear at the injection sites, warming procedures cannot be carried out; application of an iodine mesh is acceptable.
Pharmacological action of Folliculin
The presented drug has an effect similar to estrogen. It is able to normalize the menstrual cycle, restore the appearance of secondary sexual characteristics, and promote the growth of the inner tissue layer of the uterus (endometrium).
Side effects
Folliculin is well tolerated by patients, but doctors must carefully monitor the patient’s condition - with long-term therapy, the development of dysfunctional uterine bleeding is possible.
Interaction of Folliculin with other drugs
The simultaneous administration of folliculin with other hormonal agents is fraught with an excess of hormones in the body and denormalization of the functioning of the endocrine system.
Interaction with alcohol
Alcoholic drinks simultaneously with folliculin injections are acceptable, but it should be noted that in the case of long-term therapy, general side effects may occur - attacks of nausea and vomiting, severe dizziness, localized headaches.
Overdose
When the drug was prescribed by a specialist, no cases of overdose were observed. Theoretically, problems in the functioning of the central nervous system and uterine bleeding of an atypical nature may occur.
Use of folliculin during pregnancy and lactation
Pregnancy and breastfeeding are absolute contraindications to the use of the drug in question.
For newborns and children
In pediatric practice, folliculin is not used, but in the case of primary amenorrhea (absence of menstruation), it is recommended to carry out hormonal therapy from the age of 16.
Storage conditions and periods
Folliculin belongs to category B drugs - no special conditions need to be created for its storage. Shelf life – 36 months.
